Impact of vitamin D supplementation on cardiac structure and function

补充维生素 D 对心脏结构和功能的影响

基本信息

批准号：
9292464
负责人：
RAVI THADHANI
金额：
$ 3.22万
依托单位：
VANDERBILT UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-03-01 至 2017-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9292464
关键词：
Impact vitamin supplementation cardiac structure

项目摘要

DESCRIPTION (provided by applicant): Experimental and observational data suggest that vitamin D supplementation reduces left ventricular hypertrophy and improves cardiac function. Prospective clinical data, however, are lacking. Thus, we propose an ancillary study to the Vitamin D and OmegA-3 Trial (VITAL) (U01CA138962), an outcomes trial of vitamin D supplementation in 20,000 men and women (aged ¿60 and 65 years, respectively). Because VITAL lacks any direct assessment of cardiac structure and function, we propose to perform cardiac imaging with echocardiography in 1,000 VITAL subjects pre-randomization and at 3 years. These data may answer several important questions that are not being addressed by the parent trial. Specifically, VITAL is focused on vascular endpoints (myocardial infarction, stroke), raising the possibility that important effects of vitamin D on the heart itself could be missed. Because there is compelling experimental evidence regarding the direct myocardial effects of vitamin D, assessment of cardiac structure and function would provide invaluable clinical and mechanistic insight, regardless of the outcome of the overall parent trial. The investigators have extensive experience in subclinical cardiovascular imaging, coordination of randomized trials (including the parent VITAL study), and clinical and experimental nutritional research. The study represents a unique and cost- effective opportunity to investigate measures of cardiac structure and function in a large, diverse primary prevention trial.

描述（通过应用程序提供）：实验和观察数据表明，补充维生素D可减少左心室肥大并改善心脏功能。但是，缺乏前瞻性临床数据。 That, we propose an ancillary study to the Vitamin D and OmegA-3 Trial (VITAL) (U01CA138962), an outcomes trial of vitamin D supplementation in 20,000 men and women (aged ¿60 and 65 years, Because VITAL lacks any direct assessment of cardiac structure and function, we propose to perform cardiac imaging with echocardiography in 1,000 VITAL subjects pre-randomization and at 3这些数据可能会回答父母试验的几个重要问题。提高了维生素D对心脏本身的重要影响的可能性。由于有关于维生素D的直接心肌作用的令人信服的实验证据，因此对心脏结构和功能的评估将提供宝贵的临床和机械洞察力，无论总体父母的总体试验的结果如何。研究人员在亚临床心血管成像，随机试验的协调（包括家长生命研究）以及临床和实验营养研究方面具有丰富的经验。该研究代表了一个独特且具有成本效益的机会，可以研究大型，潜水的主要预防试验中心脏结构和功能的度量。