Genomics

基因组学

• 批准号: 9149793
• 负责人: Michael Hemann
• 金额: $ 16.94万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-09 至 2020-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9149793
• 关键词: Biochemical; Biopolymers; Budgets; Cancer Center; Cancer Center Support Grant; Cells; Chromatin; Core Grant; Development; Equipment; Funding; Genomics; Institutes; Libraries; Massive Parallel Sequencing; Microarray Analysis; Mission; Names; Preparation; Process; Proteomics; Reading; Research Personnel; Resource Sharing; Services; Technology; Time; Walking; anticancer research; base; cost; genome analysis; genome-wide; high throughput screening; human genome sequencing; instrument; instrumentation; member; next generation sequencing; oncology; programs; screening; small hairpin RNA; small molecule; success

The sequencing of the human genome has revolutionized cancer research. The Genomics Core is an Institutional Shared Resource, shared between the Koch Institute and three other MIT units, which provides Center Members with integrated and comprehensive services in genome-wide analyses. In the prior period, this Core (previously named the Microarray Technologies Core) focused specifically on microarray-based technologies. As part of a core-wide reorganization plan, the mission of this shared Genomics Core was greatly expanded in the current period. First, the Core took on the responsibility for providing all of our next generation sequencing capabilities (previously offered by the Biopolymers & Proteomics Core). Second, it recently established oncology-focused, high throughput small molecule and shRNA screening capabilities, with support from CCSG developmental and MIT funds. The Core also acquired new instrumentation and an expanded staff to support both of these activities. In the current period, the Core is used by more than 80% of the Center Members, including investigators from all four Programs. Thus, this Shared Resource is essential to the success of the Koch Institute mission. In the upcoming period, this Core will continue to offer a wide range of state-of-the-art genome-wide technologies to support the Koch Institute’s cancer research mission. Notably, Center Members represent 55% of the total usage of the Cores services, but the requested CCSG budget is less than 50% of the total stakeholder contributions.

人类基因组测序彻底改变了癌症研究。 机构共享资源，由科赫研究所和其他三个麻省理工学院单位共享，提供 中心成员在全基因组分析方面提供综合全面的服务。 该核心（以前称为微阵列技术核心）专门专注于基于微阵列的技术 作为整个核心重组计划的一部分，这个共享基因组学核心的使命是 首先，核心承担了提供我们接下来所有内容的责任。 其次，世代测序功能（之前由生物聚合物和蛋白质组学核心提供）。 最近建立了以肿瘤学为中心的高通量小分子和 shRNA 筛选能力， The Core 还获得了 CCSG 发展基金和 MIT 基金的支持。 扩大了人员规模以支持这两项活动。目前，超过 80% 的人员使用了核心。 中心成员，包括来自所有四个计划的研究人员，因此，这种共享资源至关重要。 为了科赫研究所使命的成功，该核心将继续提供广泛的帮助。 一系列最先进的全基因组技术来支持科赫研究所的癌症研究任务。 值得注意的是，中心成员占核心服务总使用量的 55%，但要求的 CCSG 预算少于利益相关者捐款总额的 50%。