The Role of Aging in the Progression of Tendon Degeneration Due to Compressive Mechanical Overload: A Multiscale Approach

衰老在压缩机械过载引起的肌腱退变进展中的作用：多尺度方法

基本信息

批准号：
9047918
负责人：
Brianne Kathryn Connizzo
金额：
$ 5.07万
依托单位：
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-01-01 至 2018-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9047918
关键词：
Affect Age Aging Animal Model Balance training Basic Science Biological Models Biomechanics Biomedical Engineering Cell Death Cell physiology Cells Clinical Research Diagnosis Disease Disease Progression Early treatment Economic Burden Environment Exercise Fibrocartilages Future Gene Proteins Goals Health Histology Impairment Incidence Inflammation Injury Lead Mechanics Motion Mus Orthopedics Pain Pathogenesis Pathology Phenotype Population Posture Process Property Proteoglycan Protocols documentation Quality of life Regimen Rehabilitation therapy Relative (related person)Reporting Research Research Personnel Research Training Role Rotator Cuff Shoulder Pain Site Staging System Tendon structure Therapeutic Tissue Engineering Tissues Training Training Activity Work age effect age group age related aged aging population base career development cost design disability experience fluid flow in vivo insight joint function multi-scale modeling musculoskeletal injury nanomechanics normal aging novel programs protein expression public health relevance repaired response skills stem

项目摘要

DESCRIPTION (provided by applicant): The objective of this proposal is to provide the applicant with exemplary research training in orthopedic bioengineering. To achieve this objective, a training regimen has been developed, consisting of research aims and substantial training activities. Degenerative rotator cuff disease affects greater than 50% of the aged population, leading to serious impairment of joint function and overall reduced quality of life. While external compression of the rotator cuff tendons is thought to contribute to the progression and pathogenesis of rotator cuff damage, the mechanism by which this occurs and the role of aging in this process is unknown. The overall objective of the studies proposed is to determine the baseline ability of mature and aged tendons to respond to compressive loading and to understand the consequences of an increased compressive loading environment on tendon function. The project outlined in the proposal combines work of fundamental basic research importance with work directed toward the future diagnosis and therapeutic treatment of early stage tendon degeneration. Overall, the project is designed to effectively train the applicant to develop the technical skills needed to establish a successful and independent research program in the future.

描述（由适用提供）：该提案的目的是为骨科生物工程的典范研究培训提供适用的目的。为了实现这一目标，已经开发了一种培训方案，包括研究目标和二级培训活动。退化性肩袖疾病会影响年龄较大的人群的50％以上，导致关节功能严重损害和总体降低生活质量。虽然肩袖肌腱的外部压缩被认为有助于肩袖损伤的进展和发病机理，但发生这种情况的机制以及衰老在此过程中的作用尚不清楚。提出的研究的总体目的是确定成熟和老化肌腱对压缩负荷反应的基线能力，并了解增加压缩负荷环境对肌腱功能的后果。该提案中概述的项目将基本基础研究重要性的工作与针对未来诊断和早期肌腱发育的治疗治疗的工作结合在一起。总体而言，该项目旨在有效地培训应用程序，以开发未来建立成功和独立研究计划所需的技术技能。