Updating Skeletal Maturity Methods for U.S. Children

更新美国儿童骨骼成熟度方法

• 批准号: 8900950
• 负责人: Dana L Duren
• 金额: $ 13.95万
• 依托单位: WRIGHT STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-17 至 2016-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8900950
• 关键词: Accounting; Address; African American; Age; Appearance; Asian Americans; Asians; Biological Process; Bone Density; Categories; Child; Childhood; Clinical; Clinical Management; Clinical Research; Collection; Communities; Country; Data; Data Sources; Development; Ethnic Origin; Ethnic group; Funding; Future; Generations; Goals; Growth; Health; Hispanic Americans; Hispanics; Individual; Internet; Methodology; Methods; Modeling; Nature; Not Hispanic or Latino; Online Systems; Output; Phenotype; Philadelphia; Population; Probability; Race; Relative (related person); Research Personnel; Resolution; Sampling; Sampling Studies; Secure; Shapes; Testing; Time; United States; Update; Variant; Work; base; bone; computer program; density; experience; graphical user interface; open source; peer; programs; racial and ethnic; racial/ethnic difference; sex; skeletal; trend; user-friendly

DESCRIPTION (provided by applicant): Current methods for assessing skeletal maturity in US children are inadequate both in terms of racial/ethnic representation and outdated samples. The United States is a multi-racial nation, yet skeletal maturity standards are based on white children from many generations ago. The primary goal of the proposed study is to rectify this disparity, and provide up-to-date race-specific modules in the FELS method for skeletal maturity assessment. Children of diverse racial/ethnic groups will be included via multiple existing radiographic collections nationwide. The updated method for skeletal maturity assessment will be accomplished through three specific aims. Aim 1 will determine differences between races in both the timing and tempo of skeletal maturity and its individual components. Aim 2 will re-calibrate the FELS method using data from contemporary children. This aim will also provide a new program for assessment of skeletal maturity with sex- and race- specific modules. The program will be user-friendly and open source, with both stand-alone and web-based capability. Aim 3 will integrate two new interpretive parameters into the FELS assessment program output: relative contribution of five maturation categories to skeletal age, and prediction of future catch up or slow- down in skeletal maturation for a given child. The combination of these three aims will serve to benefit the treatment and clinical management of children nationwide.

描述（由申请人提供）：当前评估美国儿童骨骼成熟的方法在种族/族裔代表和过时的样本方面都不足。美国是一个多种族的国家，但骨骼成熟标准是基于几代人以前的白人儿童。拟议的研究的主要目标是纠正这种差异，并在FELS方法中提供最新的种族特定模块进行骨骼成熟度评估。各种种族/族裔群体的儿童将通过全国多个现有的射线照相收集来包括。骨骼成熟度评估的更新方法将通过三个特定目标来完成。 AIM 1将确定种族在骨骼成熟度的时机和节奏中的差异及其个体成分。 AIM 2将使用当代儿童的数据重新校准FELS方法。这个目标还将提供一个新的计划，以评估具有性别和种族特定模块的骨骼成熟度。该程序将具有用户友好和开源，具有独立和基于Web的功能。 AIM 3将将两个新的解释参数集成到FELS评估计划输出中：五个成熟类别对骨骼时代的相对贡献，以及对未来捕获的预测 给定儿童的骨骼成熟或慢下来。这三个目标的结合将有助于全国儿童的治疗和临床管理。