Non-Animal Test Method To Determine The Ocular Safety Of Consumer Products and Chemicals

确定消费品和化学品的眼部安全性的非动物测试方法

• 批准号: 8906576
• 负责人: Stewart Lebrun
• 金额: $ 20.3万
• 依托单位: LEBRUN LABS, LLC
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-03-15 至 2017-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8906576
• 关键词: Adoption; Animal Testing; Animals; Biological Assay; Blinded; Buffers; Chemicals; Code; Consumer Product Safety; Cosmetics; Data; Documentation; Engineering; Evaluation; Eye; Funding; Goals; Individual; Interagency Coordinating Committee on the Validation of Alternative Methods; Laboratories; Laboratory Animals; Lead; Logistics; Marketing; Methods; National Institute of Environmental Health Sciences; Outcome; Performance; Phase; Production; Recruitment Activity; Reporting; Request for Proposals; Research; Safety; Savings; Small Business Innovation Research Grant; System; Testing; Time; Training; Validation; Water; chemical group; commercialization; consumer product; cost; improved; innovation; interest; irritation; meetings; member; public health relevance; response; safety testing; scale up; validation studies

 DESCRIPTION (provided by applicant): OptiSafeTM is a standardized and pre-validated non-animal test method that can be used to predict the ocular irritation potential of products and chemicals. Three unique variables are used to make an ocular irritation prediction: damage to water soluble molecules, damage to water insoluble molecules and buffering capacity. The goal of the proposed research is to validate the OptiSafeTM UMA method. There is currently a commercial and regulatory need for an accurate test to determine the ocular irritancy potential of cosmetics without harming animals.

 描述（由申请人提供）：OptiSafeTM 是一种标准化且经过预先验证的非动物测试方法，可用于预测产品和化学品的眼部刺激潜力，使用三个独特的变量来进行眼部刺激预测：对水的损害。拟议研究的目标是验证 OptiSafeTM UMA 方法，目前商业和监管需要进行准确的测试来确定眼部刺激性。化妆品的潜力而不伤害动物。