Minimizing Physical Function Decline in Older Adults Receiving Chemotherapy

最大限度地减少接受化疗的老年人的身体功能下降

• 批准号: 8717550
• 负责人: Heidi Diana Klepin
• 金额: $ 14.09万
• 依托单位: WAKE FOREST UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8717550
• 关键词: Active Learning; Acute Myelocytic Leukemia; Address; Adherence; Adverse effects; Age; American; American Society of Hematology; Area; Award; Behavior Therapy; Benchmarking; Cancer Patient; Cancer Survivor; Chronic Disease; Clinical Research; Clinical Trials; Comprehensive Cancer Center; Data; Development; Development Plans; Distress; Economic Burden; Education; Elderly; Enrollment; Environment; Exercise; Exhibits; Fatigue; Funding; Future; Geriatric Assessment; Geriatrics; Goals; Health Status; Hematology; Impairment; Inpatients; Intervention; Intervention Studies; K-Series Research Career Programs; Knowledge; Leadership; Life; Life Style; Malignant Neoplasms; Measurement; Measures; Mental Health; Mentored Patient-Oriented Research Career Development Award; Mentors; Multi-Institutional Clinical Trial; Newly Diagnosed; Observational Study; Oncologist; Outcome; Patient Self-Report; Patients; Performance; Physical Function; Physical activity; Pilot Projects; Population; Quality of life; Randomized; Randomized Controlled Trials; Research; Research Personnel; Research Project Grants; Resources; Risk; Role; Sample Size; Structure; Surveys; Symptoms; Testing; Therapeutic; Toxic effect; Training; Uncertainty; Work; behavior change; cancer care; cancer therapy; career; career development; chemotherapy; depressive symptoms; design; disability; experience; functional decline; health related quality of life; high risk; improved; innovation; intervention effect; leukemia; medical complication; medical schools; named group; older patient; oncology; physical conditioning; prevent; primary outcome; programs; research and development; secondary outcome; skills; social; therapy design; tool

DESCRIPTION (provided by applicant): Heidi D. Klepin, MD, MS will utilize this Beeson K23 award to expand her clinical research skills in measurement of physical function and design of successful physical activity interventions to maximize functional independence in high-risk elderly populations with cancer. She currently leads an observational study investigating geriatric assessment in older adults with acute myelogenous leukemia (AML) funded by a T Franklin Williams award through the American Society of Hematology. Preliminary results suggest that a high proportion of patients demonstrate objective physical impairment before treatment and exhibit significant declines in function post-chemotherapy. WFU School of Medicine is an outstanding environment in which to pursue this research and career development award. The Career Development Plan (CDP) features a strong, established interdisciplinary mentoring team with expertise in measurement of physical function, design and execution of physical activity trials in special populations (including older adults and cancer patients), and experience in multi-site clinical trials in both geriatrics and oncology. Additional key resources available include the WFU Claude D. Pepper Older Americans Independence Center and the Comprehensive Cancer Center of WFU. The CDP features ongoing structured mentoring, key formal education programs, and experiential learning through the completion of the Research Plan (RP). Most newly diagnosed cancers are in older adults, who are increasingly offered chemotherapy treatments. Cancer clinical trials, however, have largely ignored the potential consequences of chemotherapy and its side effects on short- and long-term physical function in these patients. This is a topic of high importance in geriatric oncology since functional limitations compromise quality of life, limit therapeutic options, and contribute greatly to the social and economic burden of managing chronic disease. The RP builds on prior work and focuses on the execution of a randomized symptom-adapted physical activity intervention among hospitalized older adults receiving AML chemotherapy. Information on recruitment, retention, adherence, and effect size for primary and secondary outcomes gathered during this pilot study will inform the design of a definitive R01-funded trial. In addition, execution of the RP will give Dr. Klepin key experience to fulfill the objectives of her CDP, which include a) developing expertise in measurement of physical function and in design of randomized behavioral interventions in older cancer patients receiving chemotherapy and b) developing independence as a clinician researcher in geriatric oncology. In summary, the training afforded by this proposal and executed through the RP will build upon previous work and launch Dr. Klepin's career as an independent R01-funded researcher and leader in geriatric oncology.

描述（由申请人提供）：Heidi D. Klepin，MD，MS Will Will Will Will Will将利用该Beeson K23奖来扩大她的临床研究技能，以测量身体机能和成功的身体活动干预措施，以最大程度地利用癌症的高风险老年人群体的功能独立性。她目前领导了一项观察性研究，调查了由美国血液学学会T富兰克林·威廉姆斯奖（T Franklin Williams Award）资助的急性髓性白血病（AML）老年人的老年人评估。初步结果表明，很大一部分患者在治疗前表现出客观的身体损害，并在化学后功能显着下降。 WFU医学院是一个杰出的环境，旨在获得该研究和职业发展奖。职业发展计划（CDP）具有一个强大的，建立的跨学科指导团队，具有在特殊人群（包括老年人和癌症患者）的身体功能，设计和执行体育锻炼试验方面的专业知识，以及在老年病和肿瘤学的多站点临床试验中的经验。可用的其他关键资源包括WFU Claude D. Pepper老年美国人独立中心和WFU综合癌症中心。通过完成研究计划（RP），CDP具有正在进行的结构化指导，主要的正规教育计划和体验式学习。 大多数被诊断出的癌症是在老年人中，他们越来越多地提供化学疗法。然而，癌症临床试验在很大程度上忽略了化学疗法的潜在后果及其对这些患者短期和长期身体机能的影响。由于功能限制损害了生活质量，限制治疗选择，并为管理慢性疾病的社会和经济负担做出了巨大贡献，因此这在老年肿瘤学中是一个非常重要的话题。 RP基于先前的工作，并着重于在接受AML化学疗法的住院老年人中执行随机症状适应的体育活动干预措施。在这项试点研究期间收集的主要和次要结果的招聘，保留，依从性和效果规模的信息将为一项确定的R01资助试验的设计提供信息。此外，RP的执行将为klepin博士提供关键的经验，以实现其CDP的目标，其中包括a）在接受化学疗法的老年癌症患者中发展衡量身体功能的专业知识，并设计了接受化学疗法的老年癌症患者的随机行为干预措施，b）b）在人性化肿瘤学中发展为临床研究者。总而言之，该提案提供的培训并通过RP执行的培训将基于先前的工作，并启动Klepin博士作为R01资助的独立研究人员和老年肿瘤学领导者的职业生涯。

项目成果

A clinical trial of supervised exercise for adult inpatients with acute myeloid leukemia (AML) undergoing induction chemotherapy.

• DOI: 10.1016/j.leukres.2012.05.016
• 发表时间: 2012-10
• 期刊: Leukemia research
• 影响因子: 2.7
• 作者: Alibhai SM;O'Neill S;Fisher-Schlombs K;Breunis H;Brandwein JM;Timilshina N;Tomlinson GA;Klepin HD;Culos-Reed SN
• 通讯作者: Culos-Reed SN

Individualizing treatment decisions for older adults with hematologic malignancies.

患有血液系统恶性肿瘤的老年人的个体化治疗决策。

• DOI: 10.14694/edbook_am.2013.33.208
• 发表时间: 2013
• 期刊: American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting
• 作者: Klepin,HeidiD;Rizzieri,David;Palumbo,Antonio;Magarotto,Valeria;Eichhorst,Barbara
• 通讯作者: Eichhorst,Barbara