Training in Biomolecular Pharmacology

生物分子药理学培训

• 批准号: 9062038
• 负责人: David H Farb
• 金额: $ 8.48万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9062038
• 关键词: Pharmacology; Training

DESCRIPTION (provided by applicant): The predoctoral Training Program in Biomolecular Pharmacology at Boston University was launched in 1991 as a training center that would meld quantitative principles of biomedical engineering (BME) with pharmacology and experimental therapeutics, and was honored in July 1997 with the award of an NIGMS T32. In the succeeding 14 years, this university-wide program has continued to provide a supportive learning environment for predoctoral students. Program characteristics include an innovative curriculum, interdisciplinary laboratory rotations, an industrial summer internship, and diverse research training opportunities that span the Medical and Charles-River campuses. Students enter the Program via the Departments of Pharmacology or BME. Program trainees in BME and other departments experience an integrated curriculum designed to provide enriched training in the principles and practice of pharmacology that is coordinated with specialized training in their primary discipline. Trainees in Pharmacology gain access to diverse research and educational experiences that build upon those provided by core pharmacology faculty. The core curriculum stresses fundamental pharmacological principles as well as key issues governing interactions of bioactive molecules, challenges of drug delivery for novel therapeutics, animal models for drug action, their relevance to the clinic, and the challenges for modern drug discovery. Participating faculty, originally 21 and now 52, contribute expertise in focus areas including neuropharmacology, vascular and cancer pharmacology, genomics, gene therapy, proteomics, animal models (transgenic and behavioral), structural biology, nanotechnology, systems biology and medicinal chemistry. Sites for thesis research are also located in departments of Anatomy & Neurobiology, Biochemistry, Biology, Chemistry, Medicine, Neurology, Pathology, Physiology and Biophysics, Psychiatry, and Psychology. A major innovation implemented in 2010 is the university-wide Graduate Program for Neuroscience (GPN), which is attracting a large additional pool of high quality students with interests in pharmacological neuroscience. The Program has continued offering summer internships with collaborating scientists at local pharmaceutical companies. Career guidance with active oversight by faculty and senior student mentors engages trainees and provides leadership opportunities that are relevant to their career paths whether in academia, government or the private sector. Training duration is about 5.7 years and graduating students perform exceptionally well at competing for high level positions in various sectors. There are currently 46 students (41 TGE) in the program including 4 TGE from underrepresented minorities. This renewal application seeks funding for 8 trainees each year. The requested increase in the number of slots is to leverage the increased interest of highly qualified BME and GPN candidates in pharmacology training.

描述（由申请人提供）：波士顿大学生物分子药理学博士前培训项目于 1991 年启动，作为一个培训中心，将生物医学工程 (BME) 的定量原理与药理学和实验治疗学相结合，并于 1997 年 7 月荣获NIGMS T32 奖。在接下来的 14 年里，这个全校范围的项目继续为博士前学生提供支持性的学习环境。项目特色包括创新课程、跨学科实验室轮换、工业暑期实习以及横跨医学院和查尔斯河校区的多样化研究培训机会。学生通过药理学系或 BME 进入该项目。 BME 和其他部门的项目学员将体验综合课程，旨在提供丰富的药理学原理和实践培训，并与其主要学科的专业培训相协调。药理学学员可以获得基于核心药理学教师提供的各种研究和教育经验。核心课程强调基本药理学原理以及控制生物活性分子相互作用的关键问题、新型疗法的药物输送挑战、药物作用的动物模型、它们与临床的相关性以及现代药物发现的挑战。参与的教师由最初的 21 名现在的 52 名，在神经药理学、血管和癌症药理学、基因组学、基因治疗、蛋白质组学、动物模型（转基因和行为）、结构生物学、纳米技术、系统生物学和药物化学等重点领域贡献专业知识。论文研究地点还位于解剖学和神经生物学、生物化学、生物学、化学、医学、神经病学、病理学、生理学和生物物理学、精神病学和心理学系。 2010 年实施的一项重大创新是全校神经科学研究生项目 (GPN)，该项目吸引了大量对药理学神经科学感兴趣的高素质学生。该计划继续为当地制药公司的合作科学家提供暑期实习机会。由教师和高年级学生导师积极监督的职业指导可以吸引学员，并提供与其职业道路相关的领导机会，无论是在学术界、政府还是私营部门。培训时间约为5.7年，毕业生在竞争各个行业的高级职位方面表现出色。目前该项目有 46 名学生（41 名 TGE），其中 4 名来自代表性不足的少数族裔。该续签申请每年为 8 名学员寻求资助。要求增加名额数量是为了利用高素质 BME 和 GPN 候选人对药理学培训日益增长的兴趣。