Impact of Infections on the Stability of Established Tolerance

感染对既定耐受稳定性的影响

• 批准号: 8512661
• 负责人: Anita S Chong
• 金额: $ 37.08万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8512661
• 关键词: Acute; Allografting; Biological Markers; Cells; Clinic; Clinical; Clonal Expansion; Diagnosis; Goals; Hematopoietic; Immigrant; Infection; Interleukin-6; Lead; Listeria; Listeriosis; Maintenance; Mediating; Pre-Clinical Model; Regulatory T-Lymphocyte; Reporting; T-Lymphocyte; Testing; Transplantation; Transplantation Tolerance; base; insight; microbial; novel strategies; prevent

Critical issues emerging from current attempts at inducing transplantation tolerance in the clinic include the need for biomarkers that predict and diagnose tolerance as well as for the identification of barriers to tolerance induction and maintenance. Our preliminary observations have led us to the realization that the durability of the tolerant state is variable and can be unpredictably breached by Listeria infections. The overall goal of the proposed studies Is to determine a mechanistic basis for how Infections can either erode or transiently abrogate robust tolerance after It has been stably established.

当前在临床上诱导移植耐受的尝试中出现的关键问题包括 需要预测和诊断耐受性以及识别耐受性障碍的生物标志物 感应和维护。我们的初步观察使我们意识到， 耐受状态是可变的，并且可能会被李斯特菌感染不可预测地破坏。该项目的总体目标是 拟议的研究是为了确定感染如何消退或短暂的机制基础 稳定建立后废除稳健耐受性。