Hypothalamic Control of Food Intake and Body Weight

下丘脑控制食物摄入量和体重

• 批准号: 8035572
• 负责人: Michael W Schwartz
• 金额: $ 27.34万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-25 至 2010-11-25
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8035572
• 关键词: Animals; Arts; Body Weight; Body fat; Collaborations; Eating; Environmental Risk Factor; Event; Feeding behaviors; Funding; Goals; Histocytochemistry; Homeostasis; Hypothalamic structure; Insulin; Interdisciplinary Study; Laboratories; Leptin; Neurons; Nutrient; Obesity; Pathogenesis; Physiology; Research Personnel; Resources; Signal Transduction; Structure of nucleus infundibularis hypothalami; Technology; Universities; Washington; biological systems; cell type; ghrelin; improved; interdisciplinary approach; medical schools; meetings; obesity treatment; programs; success

This Program Project proposes to facilitate an improved understanding of biological systems governing food intake, body fat mass and obesity pathogenesis. While many key molecules and neuronal cell types have been identified, it is the interactions between them, and the impact of environmental factors on these interactions, that ultimately determine the level of body fat that is defended. Identifying these interactions, and distinguishing those that are critical from those that are not, provides the overarching focus of this proposal. Because of the complexity inherent in this undertaking, this goal is best met by uniting investigators with complementary expertise and resources in an effective and productive collaboration using a multidisciplinary approach and state-of-the-art technology. Our proposal brings Dr. Greg Barsh from Stanford University School of Medicine together with established, NIH-funded investigators at the University of Washington--Drs. Michael W. Schwartz, David E. Cummings and Denis G. Baskin--in three highly-interrelated Projects that will clarify how insulin, leptin and ghrelin interact with nutrient-related signals to regulate both feeding behavior and the function of key neuronal subsets in the hypothalamic arcuate nucleus. The success of each project will depend upon interactions between them and on support provided by a Histochemistry Core and an Animal Physiology Core. Day-to-day oversight of the entire Program Project will be provided by an Administrative Core. In the event of its funding, Dr. Paul Ramsey, Dean of the University of Washington School of Medicine, has made a major commitment of new laboratory space to support the success of this endeavor. Progress in understanding signaling networks in energy homeostasis requires an interactive, multidisciplinary research program and is critical for ongoing efforts to develop more effective strategies for obesity treatment.

该计划项目旨在促进更好地了解控制食物摄入、身体脂肪量和肥胖发病机制的生物系统。虽然许多关键分子和神经元细胞类型已被识别，但它们之间的相互作用以及环境因素对这些相互作用的影响最终决定了所保护的身体脂肪水平。识别这些相互作用，并区分那些关键的相互作用 并非如此，提供了该提案的总体重点。由于这项工作固有的复杂性，这一目标的最佳实现方式是利用多学科方法和最先进的技术，将具有互补专业知识和资源的研究人员联合起来，进行有效和富有成效的合作。我们的提案汇集了斯坦福大学医学院的 Greg Barsh 博士和华盛顿大学由 NIH 资助的知名研究人员——Drs。 Michael W. Schwartz、David E. Cummings 和 Denis G. Baskin——在三个高度相关的项目中，这些项目将阐明胰岛素、瘦素和生长素释放肽如何与营养相关信号相互作用，从而调节进食行为和关键神经元亚群的功能。下丘脑弓状核。每个项目的成功将取决于它们之间的相互作用以及组织化学核心和动物生理学核心提供的支持。整个计划项目的日常监督将由行政核心负责。在获得资助后，华盛顿大学医学院院长 Paul Ramsey 博士做出了重大承诺，将提供新的实验室空间来支持这项工作的成功。理解能源信号网络的进展 体内平衡需要一个互动的、多学科的研究计划，对于持续努力制定更有效的肥胖治疗策略至关重要。

项目成果

Endothelial inflammation induced by excess glucose is associated with cytosolic glucose 6-phosphate but not increased mitochondrial respiration.

过量葡萄糖诱导的内皮炎症与胞质葡萄糖 6-磷酸有关，但与线粒体呼吸增加无关。

• 发表时间: 2009-05
• 影响因子: 8.2
• 作者: Sweet, I R;Gilbert, M;Maloney, E;Hockenbery, D M;Schwartz, M W;Kim, F
• 通讯作者: Kim, F

Receptors for tumor necrosis factor-alpha play a protective role against obesity and alter adipose tissue macrophage status.

肿瘤坏死因子-α 受体对肥胖起到保护作用，并改变脂肪组织巨噬细胞状态。

• 发表时间: 2009-09
• 影响因子: 4.8
• 作者: Pamir, Nathalie;McMillen, Timothy S;Kaiyala, Karl J;Schwartz, Michael W;LeBoeuf, Renée C
• 通讯作者: LeBoeuf, Renée C