Caenorhabditis Genetics Center

秀丽隐杆线虫遗传学中心

• 批准号: 8866245
• 负责人: Ann E. Rougvie
• 金额: $ 42.49万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2016-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8866245
• 关键词: Aging; Alzheimer' s Disease; Animal Model; Animals; Anthelmintics; Apoptosis; Applied Research; Area; Basic Science; Biological; Biology; Caenorhabditis; Caenorhabditis elegans; Chromosomal Rearrangement; Chromosomes; Collection; Communities; Country; Disease; Education; Educational process of instructing; Generations; Genes; Genetic; Genome; Goals; Health; Human; Human Development; Individual; International; Label; Livestock; Locales; Malignant Neoplasms; Marketing; MicroRNAs; Mission; Modeling; Mutation; Nematoda; Neurodegenerative Disorders; Parasitic nematode; Parkinson Disease; Policies; Publishing; RNA Interference; Recovery; Reporter Genes; Research; Research Personnel; Resources; Science; Services; Sterility; System; Technology; Transgenic Organisms; Work; base; cost; insight; model organisms databases; null mutation; repository; response; tool; tumor progression; web site

The overall objective of the Caenorhabditis Genetics Center (CGC) is to promote research on the small metazoan Caenorhabditis elegans by acquiring, maintaining, and distributing genetically characterized nematode stocks. Researchers throughout the world use genetic stocks obtained from the CGC in diverse basic and applied research endeavors. Studies using this premier model organism have led to fundamental insights into basic biological mechanisms, including the genetic basis of programmed cell death, the discovery of microRNAs, and the mechanism of RNA interference in animals. The nematode has also proved important for understanding mechanisms of cancer progression and other diseases including Alzheimer's and Parkinson's, as well as for revealing basic mechanisms underlying human development. In addition, C. elegans serves as a key model for illuminating our understanding of parasitic nematodes with relevance to human and livestock health. As the sole general stock center for the nematode C. elegans, the CGC is an extremely important international research resource. The high demand for CGC strains reflects their great importance to the research community; currently more than 25,000 strains are distributed per year. The CGC curates C. elegans strains and distributes them upon request through an on-line ordering system. A new research component will be implemented to expand the activities of the CGC. The C. elegans genetic tool-kit will be enhanced through the generation of genetic tools to aid researchers in manipulations of lethal and sterile mutations.

Caenorhabditis遗传学中心（CGC）的总体目标是通过获取，维护和分发遗传表征的线虫库存来促进对秀丽隐杆线虫小型秀丽隐杆线虫的研究。全世界的研究人员使用从CGC获得的遗传库存，用于各种基本和应用研究的努力。使用这种主要模型生物的研究导致对基本生物学机制的基本见解，包括程序性细胞死亡的遗传基础，发现microRNA的发现以及动物中RNA干扰的机制。线虫还证明对于理解癌症进展的机制和其他疾病（包括阿尔茨海默氏症和帕金森氏症）以及揭示人类发展的基本机制的机制很重要。此外，秀丽隐杆线虫是阐明我们对与人类和牲畜健康相关的寄生线虫的理解的关键模型。作为线虫C.秀丽隐杆线虫唯一的总股票中心，CGC是非常重要的国际研究资源。对CGC菌株的高需求反映了它们对研究界的重要性。目前，每年有25,000多株分布。 CGC策划秀丽隐杆线虫菌株并通过在线排序系统应要求分配它们。将实施一个新的研究组件来扩大CGC的活动。秀丽隐杆线虫的遗传工具量将通过生成遗传工具来增强，以帮助研究人员处理致命和无菌突变的操纵。