Doppler flow wires and hemodynamics in intracranial aneurysms

颅内动脉瘤的多普勒血流线和血流动力学

• 批准号: 8423319
• 负责人: Louis Joong Kim
• 金额: $ 7.45万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-02-15 至 2015-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8423319
• 关键词: 3-Dimensional; Academic Medical Centers; Address; Affect; American; Anatomy; Aneurysm; Aneurysmal Subarachnoid Hemorrhages; Angiography; Blood Flow Velocity; Blood Pressure; Blood Vessels; Blood flow; Cerebral Aneurysm; Cerebral Angiography; Cerebrum; Clinical; Clinical Research; Computer Simulation; Computer software; Computers; Disease; Engineering; Environment; Functional disorder; Future; Genetic; Image; Interdisciplinary Study; Intracranial Aneurysm; Life; Liquid substance; Location; Measurement; Measures; Mechanics; Methods; Modeling; National Institute of Neurological Disorders and Stroke; Neurosurgical Procedures; Patients; Physiological; Positioning Attribute; Property; Research; Resources; Risk; Rupture; Ruptured Aneurysm; Skin; Strategic Planning; Stratification; Stress; Subarachnoid Hemorrhage; System; Technology; Testing; Time; Universities; Washington; base; design; hemodynamics; improved; in vivo; insight; new technology; novel; research study; shear stress; translational approach

DESCRIPTION (provided by applicant): Intracranial aneurysms carry a risk of rupture with potentially life-threatening subarachnoid hemorrhage. Study of the hemodynamic properties of cerebral vasculature in patients with ruptured and unruptured intracranial aneurysms could provide insight into the factors that influence why some aneurysms rupture and others do not. Blood flow velocity within cerebral blood vessels, an important hemodynamic property in aneurysmal disease, is usually measured by probes placed on the skin, or estimated by computer modeling software. However, these methods are prone to error. We propose the measurement of both blood flow velocity and blood pressure from within precise blood vessel locations using Doppler flow wire technology during cerebral angiography for aneurysm treatment. These measurements can be applied to real-time calculations of the hemodynamic forces on intracranial aneurysms, as well as improve the accuracy of computer-based aneurysm hemodynamics modeling. The study of such measurements in aneurysm patients will provide further insight into aneurysmal disease, as well as a pathophysiological basis for treatment decisions.

描述（由申请人提供）：颅内动脉瘤有破裂的风险，并可能危及生命的蛛网膜下腔出血。对破裂和未破裂颅内动脉瘤患者脑血管系统血流动力学特性的研究可以深入了解影响某些动脉瘤破裂而另一些动脉瘤不破裂的因素。脑血管内的血流速度是动脉瘤疾病中重要的血流动力学特性，通常通过放置在皮肤上的探针进行测量，或通过计算机建模软件进行估计。然而，这些方法很容易出错。我们建议在动脉瘤治疗的脑血管造影过程中使用多普勒血流线技术从精确的血管位置测量血流速度和血压。这些测量可用于实时计算颅内动脉瘤的血流动力学力，并提高基于计算机的动脉瘤血流动力学建模的准确性。对动脉瘤患者进行此类测量的研究将进一步深入了解动脉瘤疾病，并为治疗决策提供病理生理学基础。