Serosorting Intervention for HIV Negative MSM

HIV 阴性 MSM 的血清分选干预

基本信息

批准号：
8843960
负责人：
Lisa A Eaton
金额：
$ 45.89万
依托单位：
UNIVERSITY OF CONNECTICUT STORRS
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-07-11 至 2017-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8843960
关键词：
18 year old AIDS/HIV problem Accounting Acute Address Anal Sex Awareness Behavior Therapy Belief Biological Caring Centers for Disease Control and Prevention (U.S.)Cities Communities Conflict (Psychology)Contracts Control Groups Cost Effectiveness Analysis Counseling Decision Making Diagnosis Disclosure Effectiveness Employee Strikes Epidemic Equilibrium Failure Fatigue Financial compensation Guidelines HIV HIV Infections HIV Seropositivity HIV risk Human immunodeficiency virus test Individual Infection Infection Control Informed Consent Intervention Intervention Trial Knowledge Measures Modeling Participant Prevention Public Health Randomized Randomized Controlled Trials Recruitment Activity Reporting Research Research Personnel Risk Risk Behaviors Risk Reduction Risk-Taking Safe Sex Security Services Sex Behavior Sexual Partners Sexually Transmitted Diseases Site Staging Structure Test Result Testing Time United States Public Health Service Unsafe Sex arm base behavioral outcome condoms cost design economic evaluation effective intervention high risk improved male meetings men men who have sex with men novel novel strategies prevent response scale up screening sex stem theories therapy design transmission process

项目摘要

DESCRIPTION (provided by applicant): Men who have sex with men continue to make up a majority of incident HIV infections. Despite alarmingly high rates of HIV infection, there are few effective interventions to prevent HIV transmission among these men. This five year study, proposed by a New/Early Stage Investigator, consists of a randomized controlled trial to test a behavioral intervention designed to reduce risks for HIV/AIDS posed by sexual partner selection strategies, specifically serosorting, among at-risk HIV negative men who have sex with men in Atlanta, GA. Serosorting - limiting unprotected sexual partners to those of the same HIV status- has emerged as a risk reduction strategy with little input from public health agencies. It is commonly practiced among men who have sex with men to avoid HIV infection. However, engaging in serosorting is a predictor of HIV transmission rather than a reliable form of prevention. Serosorting is ineffective due to several factors, including: multiple flaws in the ability to be certain of own or partner's HIV statuses, the failure of routine HIV tests to detect acute HIV infection, elevated infectiousness due to acute HIV infection, and increased risk for contracting other STIs that can facilitate HIV transmission. We are therefore proposing to test a brief, single-session, Conflict Theory of Decision Making based intervention for use in public health settings. This project uses a novel theory of informed decision making to guide an intervention designed for use in routine services, i.e., HIV post-test counseling. An intervention to address the needs of men who test HIV negative fits well with current efforts to scale up HIV testing, also referred to as seek, test and treat. The proposed research builds on the strengths of a pilot tested, behavioral intervention for addressing serosorting among men who have sex with men. Following screening, informed consent, baseline assessments, and HIV testing (we predict 70 men will test HIV positive), 600 HIV- negative participants will be randomly assigned to receive one of two intervention arms: (a) a serosorting, partner selection intervention, or (b) a time-match, CDC based, post-HIV test counseling, standard-of-care. Participants will be followed over 12-months and assessments will include measures of serosorting beliefs, decisional balance, knowledge of acute HIV infection, HIV status disclosure, and biological (incident STI) and behavioral outcomes (sexual behaviors). This study will test the hypotheses that a brief, single session, serosorting intervention will result in less risk-related serosorting beliefs, greater knowledge/awareness of HIV transmission risk taking, increased HIV status disclosure, reductions in number of sex partners, unprotected sex acts, and incident STIs among intervention participants more so than the control group participants. Moreover, we will test the hypothesis that the intervention will be cost saving when tested in cost-effectiveness analyses. If shown effective, the intervention model will be ready for immediate dissemination to HIV testing services. Effective and novel strategies for reducing risk taking among men who have sex with men are urgently needed to reduce the disproportionate rate of incident HIV infections among this highest risk group.

描述（由申请人提供）：与男性发生性关系的男性继续构成大多数事件艾滋病毒感染。尽管艾滋病毒感染率高得令人震惊，但几乎没有有效的干预措施可以防止这些男性传播艾滋病毒。这项五年的研究是由新的/早期研究者提出的，由一项随机对照试验组成，该试验旨在测试一种行为干预措施，旨在减少性伴侣选择策略构成的艾滋病毒/艾滋病风险，尤其是在佐治亚州亚特兰大与男性发生性关系的高危艾滋病毒负面男性中。血清静脉 - 将未受保护的性伴侣限制为同一艾滋病毒状况的性伴侣 - 已成为一种降低风险策略，而公共卫生机构的投入很少。它通常是在与男性发生性关系的男性中进行的，以避免艾滋病毒感染。但是，参与血清分类是HIV传播的预测指标，而不是可靠的预防形式。血清分类由于多个因素而无效，包括：具有某些或伴侣的HIV状态的能力多个缺陷，常规HIV测试未能检测急性HIV感染，急性HIV感染引起的感染性升高，以及增加其他性病的风险增加，可以促进HIV传播。因此，我们建议测试基于决策的干预措施在公共卫生环境中使用的简短，单节，冲突理论。该项目使用一种新颖的知情决策理论来指导旨在用于常规服务的干预措施，即艾滋病毒后测试后咨询。解决测试艾滋病毒负面测试的男性需求的干预措施与当前在扩展艾滋病毒测试的努力（也称为寻求，测试和治疗）非常吻合。拟议的研究基于经过测试的飞行员的优势，行为干预，以解决与男性发生性关系的男性中的塞罗瑟列表。筛选，知情同意，基线评估和HIV测试（我们预计70名男性将测试HIV阳性），将随机分配600名HIV-PANIG参与者接受两个干预臂之一：（a）塞罗瑟罗治疗，伴侣选择干预措施，或（b）时间匹配，基于CDC的基于CDC的，HIV后测试后，HIV测试后的辅导，标准的标准辅助。参与者将被遵循超过12个月的时间，评估将包括降级信念，决策平衡，急性HIV感染知识，HIV状态披露以及生物学（事件性STI）和行为结果（性行为）（性行为）。这项研究将检验以下假设：简短的单一会议，血清分类干预将导致与风险相关的血清疗法信念，更大的知识/对HIV传播风险的知识/意识更高，艾滋病毒状况披露的增加，性伴侣的减少，无预防的性行为的减少，无害的性行为以及在干预参与者中的事件参与者比对照组的参与者更多。此外，我们将检验以下假设：在成本效益分析中进行测试时，干预措施将节省成本。如果显示有效，干预模型将准备好立即传播艾滋病毒测试服务。迫切需要与男性发生性关系的男性冒险的有效和新颖的策略，以降低该最高风险组中艾滋病毒感染的不成比例。

项目成果

期刊论文数量（15）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Transactional Sex With Regular and Casual Partners Among Young Men Who Have Sex With Men in the Detroit Metro Area.

DOI：
10.1177/1557988315609110
发表时间：
2017-05
期刊：
American journal of men's health
影响因子：
0
作者：
Bauermeister JA;Eaton L;Meanley S;Pingel ES;UHIP Partnership
通讯作者：
UHIP Partnership

An evaluation of factors associated with sexual risk taking among Black men who have sex with men: a comparison of younger and older populations.

DOI：
10.1007/s10865-016-9734-x
发表时间：
2016-08
期刊：
Journal of behavioral medicine
影响因子：
3.1
作者：
Maksut JL;Eaton LA;Siembida EJ;Driffin DD;Baldwin R
通讯作者：
Baldwin R

Black men who have sex with men, sexual risk-taking, and willingness to use rapid home HIV tests.

DOI：
10.1007/s11121-014-0496-9
发表时间：
2015-02
期刊：
PREVENTION SCIENCE
影响因子：
3.5
作者：
Eaton, Lisa A.;Driffin, Daniel D.;Smith, Harlan;Conway-Washington, Christopher;White, Denise;Cherry, Chauncey
通讯作者：
Cherry, Chauncey

Stigma and Conspiracy Beliefs Related to Pre-exposure Prophylaxis (PrEP) and Interest in Using PrEP Among Black and White Men and Transgender Women Who Have Sex with Men.