Research Training in Infection and Immunity

感染与免疫研究培训

• 批准号: 8856464
• 负责人: Robert L. Atmar
• 金额: $ 21.81万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-01 至 2019-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8856464
• 关键词: Immunity; Infection; Research Training

DESCRIPTION (provided by applicant): This is the resubmission of a NRSA competing renewal application for Years 12-17 of a training program designed to produce investigators at the cutting edge of research in infectious diseases and immunity. Trainees will be at the postdoctoral level and a mixture of MDs and PhDs each supported for 2 years for a total request of 3 stipends/yr. to accomplish this goal. At this time, ours is the sole NRSA existing within BCM or the Texas Medical Center that supports clinical research training in non-AIDS infections and global health. Superb training opportunities exist at BCM in a number of areas. Participating projects directed by 23 mentors (8 MDs, 4 MD/PhDs and 11 PhDs) with strong records of federal funding and training experience include: 1) Cellular and Structural Biology of Innate Immunity, 2) Novel Drug-, Cell- and Probiotic-based Therapeutics, 3) Viral and Bacterial Gastroenteritis, 4) Viral and Bacterial Oncogenesis, 5) Vaccine Development and Evaluation, 6) High- resolution Structures of Viruses and Cellular Nanomachines, 7) Functional Genomics of Pathogens, and 8) Device-related Infections. Total grant support in FY2014 for the projects participating in this NRSA Program is approximately $33M. The structure of the Program for Research Training in Infections and Immunity contains three training tracks that can be pursued by trainees: 1) laboratory-based clinical research, 2) clinical trials and epidemiology research and 3) global health research. The Program Director, David J. Tweardy MD, maintains ultimate authority for the program and manages day-to-day operations. He is assisted by two other member of the Executive Committee, Associate Program Director, Mary Estes PhD, and Peter Hotez MD PhD, Dean of the National School for Tropical Medicine. Selection of trainees is performed by the Selection Committee, which includes the Executive Committee and three other program faculty. The training program for MD fellows includes research rotations to facilitate selection of a mentor. Both MD and PhD trainees have individual research committees, must prepare a written research proposal to be defended to the research committee, and have yearly reviews that include academic and career assessment. Both MD and PhD fellows are required to attend a monthly research-in-progress seminar series, a weekly journal club, and a yearly scientific social. All trainees must present at these meetings. The Adult and Pediatric Infectious Diseases Training Programs at BCM and other Departments participating in this NRSA have shown they can attract highly qualified, training- grant eligible postdoctoral trainee candidates including nearly two under-represented minority candidates per year. Twelve trainees have completed training supported by this Award, thus far. As a group, they have published a total of 118 peer-reviewed manuscripts resulting from their postdoctoral fellowship training (9.8 manuscripts per graduate; 59% first-authored by the graduate). In addition, these graduates have been awarded a total of $4.9M in external funding from the NIH and other competitive sources. All but one graduate continues to pursue an academic or industry-based infectious diseases career.

描述（由申请人提供）：这是 NRSA 重新提交的第 12-17 年培训计划的竞争更新申请，旨在培养处于传染病和免疫研究前沿的研究人员。受训者将处于博士后级别，其中包括医学博士和博士，每人获得 2 年的资助，每年总共请求 3 笔津贴。为了实现这个目标。目前，我们的 NRSA 是 BCM 或德克萨斯医学中心内唯一支持非艾滋病感染和全球健康临床研究培训的 NRSA。 BCM 在许多领域都提供极好的培训机会。由 23 名导师（8 名医学博士、4 名医学博士/博士和 11 名博士）指导的参与项目包括：1) 先天免疫的细胞和结构生物学，2) 新型药物、细胞和益生菌-基于治疗学，3) 病毒和细菌性胃肠炎，4) 病毒和细菌肿瘤发生，5) 疫苗开发和评估，6）病毒和细胞纳米机器的高分辨率结构，7）病原体的功能基因组学，以及8）设备相关的感染。 2014 财年，参与该 NRSA 计划的项目的赠款支持总额约为 3300 万美元。感染和免疫研究培训计划的结构包含学员可以参加的三个培训课程：1) 基于实验室的临床研究，2) 临床试验和流行病学研究以及 3) 全球健康研究。项目总监 David J. Tweardy MD 拥有该项目的最终权力并管理日常运营。他由执行委员会的另外两名成员、项目副主任 Mary Estes 博士和国家热带医学学院院长 Peter Hotez 医学博士协助。学员的选拔由选拔委员会执行，该委员会包括执行委员会和其他三名项目教员。医学博士研究员的培训计划包括研究轮换，以方便选择导师。医学博士和博士生都有单独的研究委员会，必须准备一份书面研究计划以向研究委员会辩护，并进行包括学术和职业评估在内的年度审查。医学博士和博士生都必须参加每月一次的正在进行的研究研讨会系列、每周一次的期刊俱乐部和每年一次的科学社交活动。所有学员都必须出席这些会议。 BCM 和参与 NRSA 的其他部门的成人和儿童传染病培训计划表明，他们每年可以吸引高素质、符合培训补助金资格的博士后实习生候选人，其中包括每年近两名代表性不足的少数族裔候选人。到目前为止，已有 12 名学员完成了该奖项支持的培训。作为一个群体，他们在博士后培训中总共发表了 118 篇经过同行评审的手稿（每位毕业生 9.8 篇手稿；59% 是毕业生的第一作者）。此外，这些毕业生还获得了来自 NIH 和其他竞争性来源的总计 490 万美元的外部资助。除一名毕业生外，所有毕业生都继续从事学术或基于行业的传染病职业。