Malarial Retinopathy Screening System for Improved Diagnosis of Cerebral Malaria

疟疾视网膜病变筛查系统可改善脑型疟疾的诊断

基本信息

  • 批准号:
    8850325
  • 负责人:
  • 金额:
    $ 19.98万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2014
  • 资助国家:
    美国
  • 起止时间:
    2014-06-01 至 2016-05-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): VisionQuest Biomedical and its collaborators have assembled a team of inter-disciplinary scientists with considerable experience in automated retinal image analysis, clinical ophthalmology with specialized research in malarial retinopathy (MR), and cerebral malaria diagnosis (CM). This team will develop and test an automated MR screening software system integrated with a low-cost and portable retinal camera, iRxCam, developed by VisionQuest; to assist and improve the accuracy of CM diagnosis. CM is the most lethal clinical syndrome associated with malarial disease. It affects more than 200 million people annually and claims about 800,000 deaths worldwide which include 700,000 mortalities from African children. As a consequence of high incidence of CM, it is often misdiagnosed for other pathologies with similar symptoms, leading to an incorrect treatment. Once clinically suspected, an accurate means to confirm the presence of CM or to investigate for a non-malarial illness is critically needed to improve outcomes. Since MR is greater than 90% sensitive and specific to the presence of CM once clinically diagnosed, retinal screening for MR represents an effective means to assist and improve the specificity of CM diagnosis. Our proposed system will not replace the current CM diagnostic standard, but instead will be added to it to increase the accuracy of CM diagnosis leading to a smaller number of false positive outcomes. We propose a fully automated MR screening system that eliminates the need of clinical expertise and equipment, as well as its low-cost and portability make this system more accessible and affordable to affected population in Africa. There are three specific aims to be achieved in phase I of this project. First, we will develop new methods and adapt previously developed methods for automated detection of retinal signs of MR and test them using a retrospective image data. The second aim will focus on interfacing the automated software system with the low-cost and portable retinal camera developed by VisionQuest. Third, we will test our software system on a retrospective image data obtained from diabetic retinopathy patients imaged with our camera to demonstrate the applicability of the software system on images obtained from our camera.
描述(由申请人提供):VisionQuest Biomedical 及其合作者组建了一支跨学科科学家团队,在自动视网膜图像分析、临床眼科、疟疾视网膜病变 (MR) 和脑型疟疾诊断 (CM) 方面拥有丰富的经验。该团队将开发和测试自动 MR 筛查软件系统,该系统与由 VisionQuest 开发的低成本便携式视网膜相机 iRxCam 集成;协助并提高CM诊断的准确性。 CM 是与疟疾疾病相关的最致命的临床综合征。它每年影响超过 2 亿人,导致全球约 80 万人死亡,其中包括 70 万人死于非洲儿童。由于 CM 的高发病率,它经常被误诊为具有类似症状的其他疾病,从而导致不正确的治疗。一旦临床怀疑,迫切需要一种准确的方法来确认 CM 的存在或调查非疟疾疾病,以改善结果。由于一旦临床诊断,MR 对 CM 的存在具有超过 90% 的敏感性和特异性,因此 MR 的视网膜筛查是辅助和提高 CM 诊断特异性的有效手段。我们提出的系统不会取代当前的 CM 诊断标准,而是会添加到其中以提高 CM 诊断的准确性,从而减少假阳性结果的数量。我们提出了一种全自动 MR 筛查系统,无需临床专业知识和设备,而且其低成本和便携性使该系统对于非洲受影响的人群来说更容易使用和负担得起。该项目第一阶段要实现三个具体目标。首先,我们将开发新方法并采用以前开发的方法来自动检测 MR 视网膜迹象,并使用回顾性图像数据对其进行测试。第二个目标将侧重于将自动化软件系统与 VisionQuest 开发的低成本便携式视网膜相机连接起来。第三,我们将在从用我们的相机拍摄的糖尿病视网膜病变患者获得的回顾性图像数据上测试我们的软件系统,以证明软件系统对从我们的相机获得的图像的适用性。

项目成果

期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Comparison of the effectiveness of three retinal camera technologies for malarial retinopathy detection in Malawi.
比较三种视网膜摄像技术在马拉维检测疟疾视网膜病变的效果。
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Vinayak S Joshi其他文献

Vinayak S Joshi的其他文献

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{{ truncateString('Vinayak S Joshi', 18)}}的其他基金

Automated system to improve compliance to diabetic retinopathy screening
自动化系统可提高糖尿病视网膜病变筛查的依从性
  • 批准号:
    10697609
  • 财政年份:
    2023
  • 资助金额:
    $ 19.98万
  • 项目类别:
Malarial retinopathy screening system for improved diagnosis of cerebral malaria
疟疾视网膜病变筛查系统可改善脑型疟疾的诊断
  • 批准号:
    10401912
  • 财政年份:
    2021
  • 资助金额:
    $ 19.98万
  • 项目类别:
Malarial retinopathy screening system for improved diagnosis of cerebral malaria
疟疾视网膜病变筛查系统可改善脑型疟疾的诊断
  • 批准号:
    10253474
  • 财政年份:
    2021
  • 资助金额:
    $ 19.98万
  • 项目类别:
Comprehensive Assessment of Retinal Vasculature (CARV)
视网膜血管系统综合评估(CARV)
  • 批准号:
    8905943
  • 财政年份:
    2014
  • 资助金额:
    $ 19.98万
  • 项目类别:
Comprehensive Assessment of Retinal Vasculature (CARV)
视网膜血管系统综合评估(CARV)
  • 批准号:
    8644662
  • 财政年份:
    2014
  • 资助金额:
    $ 19.98万
  • 项目类别:
Comprehensive Assessment of Retinal Vasculature (CARV)
视网膜血管系统综合评估(CARV)
  • 批准号:
    9146953
  • 财政年份:
    2014
  • 资助金额:
    $ 19.98万
  • 项目类别:
Malarial Retinopathy Screening System for Improved Diagnosis of Cerebral Malaria
疟疾视网膜病变筛查系统可改善脑型疟疾的诊断
  • 批准号:
    8714453
  • 财政年份:
    2014
  • 资助金额:
    $ 19.98万
  • 项目类别:

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