Assembly and Function of Olfactory Circuitry from Dbxl-derived Neural Progenitors

Dbxl 衍生神经祖细胞嗅觉回路的组装和功能

• 批准号: 8506230
• 负责人: JOSHUA G CORBIN
• 金额: $ 37.23万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-02-01 至 2018-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8506230
• 关键词: Aggressive behavior; Autistic Disorder; Behavior; Behavioral; Biological Models; Brain; Collaborations; Complex; Cues; Data; Destinations; Development; Disease; Electrophysiology (science); Embryo; Embryonic Development; Gene Expression; Generations; Genes; Genetic; Hormonal; Human; Instinct; Knowledge; Label; Limbic System; Link; Maps; Mediating; Methodology; Modeling; Molecular; Mus; Mutant Strains Mice; Neurons; Neurosciences; Olfactory Epithelium; Output; Pattern; Pheromone; Population; Process; Reproduction; Research Personnel; Route; Schizophrenia; Sensory; Shapes; Source; Specific qualifier value; Specificity; Stimulus; Stream; System; Telencephalon; Testing; autism spectrum disorder; base; behavior test; developmental disease; feeding; homeodomain; information processing; insight; interdisciplinary approach; multidisciplinary; nerve stem cell; neural patterning; neurogenesis; neuronal patterning; novel; olfactory bulb; optogenetics; progenitor; programs; public health relevance; relating to nervous system; reproductive; research study; sensory system; social; transcription factor; vomeronasal organ

DESCRIPTION (provided by applicant): How neural developmental programs are linked to the establishment of mature brain circuits and related behavior remains a central question of neuroscience. Our previous studies revealed that a class of neural progenitors defined by the expression of the homeodomain encoding transcription factor, Dbx1, are dedicated for the generation of subsets of neurons of the limbic system including the olfactory bulb. Based on these findings, we hypothesize that Dbx1+ progenitors located in a distinct embryonic niche generate a functionally distinct interconnected subset of olfactory bulb output neurons that are dedicated to the processing of subsets of innate behaviors. Testing of this hypothesis will be accomplished using a combination of multidisciplinary approaches including genetic fate mapping, optogenetics and innate behavioral testing.

描述（由申请人提供）：神经发育程序如何与成熟大脑回路和相关行为的建立联系起来仍然是神经科学的核心问题。我们之前的研究表明，由同源域编码转录因子 Dbx1 的表达定义的一类神经祖细胞专门用于生成包括嗅球在内的边缘系统神经元子集。基于这些发现，我们假设位于不同胚胎生态位的 Dbx1+ 祖细胞产生功能不同的嗅球输出神经元的互连子集，这些神经元致力于处理先天行为的子集。这一假设的测试将通过结合多学科方法来完成，包括遗传命运图谱、光遗传学和先天行为测试。