Comprehensive MRI near Total Joint Replacements

全关节置换附近的综合 MRI

基本信息

批准号：
8755614
负责人：
Brian Andrew Hargreaves
金额：
$ 54.42万
依托单位：
STANFORD UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-07-01 至 2018-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8755614
关键词：
Acceleration Adoption Arthroplasty Clinic Clinical Custom Data Dental Dependence Detection Development Devices Diagnosis Diagnostic radiologic examination Early Diagnosis Environment Evaluation Fracture Health Heating Hip region structure Histologic Image Image Analysis Imagery Imaging Device Implant Individual Infection Joints Longevity Magnetic Resonance Imaging Maps Measurement Measures Metals Methods Monitor Morphologic artifacts Operative Surgical Procedures Orthopedic Procedures Orthopedic Surgery procedures Osteolysis Outcome Pain Pathology Patients Prosthesis Relaxation Replacement Arthroplasty Research Resolution Role Safety Sampling Scanning Slice Speed Spinal Synovitis Techniques Technology Temperature Testing Thermometry Three-Dimensional Image Time Translations United States Unnecessary Surgery Use of New Techniques Work arthropathies base bone bone loss clinical practice cost diagnostic accuracy experience human subject image reconstruction improved in vivo innovation knee replacement arthroplasty method development novel prospective reconstruction research clinical testing sample fixation screening standard of care tool

项目摘要

DESCRIPTION (provided by applicant): This project aims to provide routine MRI of subjects with total joint replacements by reducing the severe image artifacts near metal, while offering highly efficient patient-specific scans that can detect bone loss, infection, and temparature changes near the implant in clinically feasible scan times. Relevance: Total joint replacements are one of the most successful orthopedic procedures, used annually to reduce pain from joint diseases in about one million patients in the United States (a number projected to double by 2030). However, about 10% of joint replacements fail in 5-10 years due to bone loss (osteolysis), infection, or other complications, often leading to revision surgery. Accurate, early non-invasive assessment of complications remains limited, but would offer earlier and less invasive treatments, reduce unnecessary surgery, or allow better surgical planning. Approach: We have previously developed novel MRI techniques that allow visualization of pathology adjacent to metallic implants, and together with other groups have successfully applied them to imaging of patients with devices including joint replacements and spinal fixation hardware. However these methods remain slow, have limited spatial resolution, and are challenging to use routinely. Therefore our aims are (1) to provide patient- specific scans that increase imaging efficiency for different types of implant, (2) to further accelerate scans with advanced sampling and image reconstruction, (3) to offer non-invasive temperature measurement near implants during MRI and (4) to validate all methods at 3T in patients with total joint replacements to measure imaging improvements as well as to assess diagnostic accuracy and the role of our new MRI methods in patient evaluation prior to revision surgery. Summary: We aim to offer comprehensive MRI techniques for patients with joint replacements with compa- rable scan times and resolution to conventional MRI, but with complete correction of image artifacts. These techniques will allow routine, non-invasive evaluation for earlier and more accurate detection and treatment of complications in these patients, as well as numerous other applications of MRI near metal implants.

描述（由申请人提供）：该项目旨在通过减少金属附近的严重图像伪像，同时提供高效的患者特异性扫描，从而提供总体置换的受试者的常规MRI植入临床可行的扫描时间。相关性：总置换术是最成功的骨科手术之一，每年用于减轻美国约一百万患者的关节疾病（预计到2030年的两倍）。但是，由于骨质流失（骨溶解），感染或其他并发症，约有10％的关节置换量未能在5 - 10年内失败，这通常会导致修订手术。准确，早期的非侵入性评估仍然有限，但会提供早期且较少的侵入性治疗，减少不必要的手术或允许更好的手术计划。方法：我们以前已经开发了新型的MRI技术，这些技术允许可视化与金属植入物相邻的病理学，并与其他组一起成功地将它们应用于具有设备的患者的成像，包括关节置换和脊柱固定硬件。但是，这些方法保持缓慢，空间分辨率有限，并且常规使用挑战。因此，我们的目的是（1）提供特定于患者的扫描，以提高不同类型植入物的成像效率，（2）通过高级采样和图像重建进一步加速扫描，（3）在植入期间在植入物附近提供非侵入性温度测量。 MRI和（4）验证总关节置换术的患者的所有方法在3T中进行了测量改进，并评估诊断准确性以及我们新的MRI方法在翻修手术之前在患者评估中的作用。摘要：我们旨在为具有综合扫描时间和解决常规MRI的关节置换患者提供全面的MRI技术，但可以完全校正图像伪像。这些技术将允许常规的，无创的评估，以对这些患者的并发症以及MRI在金属植入物附近的许多其他应用中进行更准确的检测和治疗。