Mentoring in HIV and Tuberculosis Research

艾滋病毒和结核病研究的指导

• 批准号: 8645585
• 负责人: TIMOTHY R STERLING
• 金额: $ 15万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-06-01 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8645585
• 关键词: Academic Medical Centers; Animal Model; Area; Award; Bacterial Infections; Base Pairing; Capromycin; Clinical Investigator; Clinical Research; Clinical Trials; Color; Communicable Diseases; Conflict of Interest; DNA Gyrase; Data; Development; Diagnosis; Disease; Doctor of Medicine; Drug Formulations; Drug Resistant Tuberculosis; Drug resistance; Effectiveness; Environment; Epidemiology; Ethics; Extreme drug resistant tuberculosis; Fluoroquinolones; Funding; Future; Gatifloxacin; Gene Mutation; Generations; Genes; Genetic; Genetic Polymorphism; Grant; HIV; HIV Infections; Health Services Research; Human; Human Resources; Immunogenetics; In Vitro; Infection; Injectable; Location; Lung; Manuscripts; Master of Science; Measures; Medicine; Mentors; Mid-Career Clinical Scientist Award (K24); Minimum Inhibitory Concentration measurement; Moxifloxacin; Multidrug-Resistant Tuberculosis; Mutation; Mycobacterium tuberculosis; National Institute of Allergy and Infectious Disease; Newly Diagnosed; Oral; Outcome; Outpatients; Patients; Persons; Pharmaceutical Preparations; Phase; Physicians; Play; Pneumonia; Predictive Value; Preparation; Prevalence; Principal Investigator; Public Health; Publications; Publishing; Regimen; Reporting; Research; Research Design; Research Infrastructure; Research Personnel; Resistance; Rifampin; Risk Factors; Role; Scientist; Sinusitis; Time; Time Management; Training; Training Programs; Translational Research; Treatment Effectiveness; Tuberculosis; Underrepresented Minority; United States National Institutes of Health; Urinary tract infection; Variant; Woman; Work; Writing; antiretroviral therapy; base; career; fluoroquinolone resistance; genetic variant; improved; in vivo; isoniazid; next generation; novel; novel strategies; patient oriented research; point of care; programs; quinolone resistance; resistance mutation; success; treatment duration; trend; tuberculosis treatment

DESCRIPTION (provided by applicant): Timothy R. Sterling, M.D. is on the Physician-Scientist (tenure) track at Vanderbilt University Medical Center, with 80% effort dedicated to research. He seeks funding for the K24 Mid-Career Investigator Award to expand his patient-oriented research program in HIV and tuberculosis, and to mentor clinical investigators in these areas. Dr. Sterling has consistently demonstrated a commitment to epidemiological and translational research in HIV and tuberculosis, and has mentored 46 young investigators to date. His trainees have been very successful in publishing their work, and almost all have remained in academic medicine. The environment at Vanderbilt is extremely conducive to training clinical investigators, with an active General Clinical Research Center, degree programs in Masters in Public Health and Masters of Science in Clinical Investigation (both supported by a NIH CTSA award), and several training grants (T32), including infectious diseases, pulmonary, and health services research. There are also several training programs dedicated to women and under-represented minorities. Dr. Sterling has a comprehensive mentoring plan that focuses on ethical conduct of research, formulation of a scientific question, study design, study conduct, manuscript preparation, grant writing, time management, oral presentations, potential conflicts of interest, establishment of a national reputation and establishment of independence. Dr. Sterling's research is focused on the following areas: 1) outcomes of HIV infection that influence timing of antiretroviral therapy initiation; 2) immunogenetic risk factors for tuberculosis infection and disease; 3) novel strategies to treat M. tuberculosis infection and disease; and 4) optimizing effectiveness of treatment of tuberculosis in HIV-infected persons. Future research will also focus on fluoroquinolone resistance in M. tuberculosis, and its possible association with HIV infection. Given the tremendous global burden of HIV and tuberculosis, highly-skilled investigators are needed to guide and improve treatment of both diseases. Due to the disproportionate impact that these diseases have had on women and persons of color, investigators from these demographic groups are particularly needed. The K24 award will allow Dr. Sterling to continue to pursue his highly-productive career in patient-oriented research in HIV and tuberculosis, and mentor the next generation of researchers to do the same. Narrative: This work will enhance the mentoring of young investigators in HIV and tuberculosis research. There will be a focus on fluoroquinolone resistance in M. tuberculosis.

描述（由申请人提供）：蒂莫西·R·斯特林（Timothy R. Sterling），医学博士（M.D.他寻求为K24中级研究员奖的资金，以扩大其面向患者的艾滋病毒和结核病研究计划，并在这些领域指导临床研究人员。斯特林博士一直表现出对艾滋病毒和结核病流行病学和转化研究的承诺，并指导了46名年轻研究者。他的学员在出版工作方面非常成功，几乎所有人都一直在学术医学上。范德比尔特（Vanderbilt）的环境极为有利于培训临床研究人员，拥有活跃的一般临床研究中心，公共卫生硕士学位和临床研究科学硕士学位（均得到NIH CTSA奖的支持）以及几项培训补助金（T32），包括感染性疾病，肺部和健康服务研究。还有一些专门针对妇女和代表性不足的少数民族的培训计划。斯特林博士制定了一项全面的指导计划，侧重于研究的道德行为，一项科学问题，研究设计，研究行为，手稿准备，赠款写作，时间管理，口头陈述，潜在的利益冲突，建立民族声誉和独立建立。 Sterling博士的研究重点是以下领域：1）影响抗逆转录病毒疗法开始的HIV感染结果； 2）结核病感染和疾病的免疫遗传危险因素； 3）治疗结核分枝杆菌感染和疾病的新型策略； 4）优化对艾滋病毒感染者的结核病治疗的有效性。未来的研究还将集中在结核分枝杆菌中的氟喹诺酮耐药性及其与HIV感染的可能关联。鉴于全球艾滋病毒和结核病的巨大负担，需要高技能的研究人员来指导和改善两种疾病的治疗。由于这些疾病对妇女和有色人种的影响不成比例的影响，因此特别需要这些人口组的研究人员。 K24奖将使Sterling博士继续从事他在艾滋病毒和结核病方面的患者研究方面的生产率，并指导下一代研究人员做同样的事情。 叙述：这项工作将增强对艾滋病毒和结核病研究的年轻研究人员的指导。在结核分枝杆菌中，将重点关注氟喹诺酮抗性。

项目成果

Treatment of Latent Tuberculosis Infection in HIV: Shorter or Longer?

• DOI: 10.1007/s11904-012-0120-1
• 发表时间: 2012-09-01
• 期刊: CURRENT HIV/AIDS REPORTS
• 影响因子: 4.6
• 作者: Person, Anna K.;Sterling, Timothy R.
• 通讯作者: Sterling, Timothy R.

Agreement of decision analyses and subsequent clinical studies in infectious diseases.

传染病决策分析和后续临床研究的一致性。

• DOI: 10.1016/j.amjmed.2006.08.032
• 发表时间: 2007
• 期刊: The American journal of medicine
• 作者: Bress,JoshuaN;Hulgan,Todd;Lyon,JenniferA;Johnston,CeciliaP;Lehmann,Harold;Sterling,TimothyR
• 通讯作者: Sterling,TimothyR

Missed opportunities for tuberculosis screening in primary care.

错过了初级保健结核病筛查的机会。

• DOI: 10.1016/j.jpeds.2015.01.037
• 发表时间: 2015
• 期刊: The Journal of pediatrics
• 作者: vanderHeijden,YuriF;Heerman,WilliamJ;McFadden,Sara;Zhu,Yuwei;Patterson,BarronL
• 通讯作者: Patterson,BarronL

Antiretroviral therapy for prevention of tuberculosis in adults with HIV: a systematic review and meta-analysis.

• DOI: 10.1371/journal.pmed.1001270
• 发表时间: 2012
• 期刊: PLoS medicine
• 影响因子: 15.8
• 作者: Suthar AB;Lawn SD;del Amo J;Getahun H;Dye C;Sculier D;Sterling TR;Chaisson RE;Williams BG;Harries AD;Granich RM
• 通讯作者: Granich RM

Tuberculosis and the risk of infection with other intracellular bacteria: a population-based study.

• DOI: 10.1017/s0950268814002131
• 发表时间: 2015-04
• 期刊: EPIDEMIOLOGY AND INFECTION
• 影响因子: 4.2
• 作者: Huaman, M. A.;Fiske, C. T.;Jones, T. F.;Warkentin, J.;Shepherd, B. E.;Ingram, L. A.;Maruri, F.;Sterling, T. R.
• 通讯作者: Sterling, T. R.