Perceptual and central auditory consequences of noise-induced hearing loss

噪声引起的听力损失的知觉和中枢听觉后果

• 批准号: 8431961
• 负责人: Amanda M. Lauer
• 金额: $ 16.2万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-12-01 至 2015-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8431961
• 关键词: Academic achievement; Acoustic Nerve; Acoustics; Acquired Deafness; Acute; Affect; Auditory; Auditory system; Behavioral; Brain; Brain Stem; Cells; Cochlear nucleus; Cognition; Complex; Detection; Deterioration; Electron Microscopy; Excitatory Synapse; Goals; Grant; Hair Cells; Hearing; Hearing Aids; Human; Immunohistochemistry; Inherited; Inhibitory Synapse; Intervention; Investigation; Knowledge; Labyrinth; Link; Loudness Perception; Measures; Monitor; Morphology; Mus; Nerve Fibers; Noise; Noise-Induced Hearing Loss; Octopus; Outcome; Pathologic; Performance; Peripheral; Pharmacotherapy; Phenotype; Physiological; Presynaptic Terminals; Prevention; Prevention Guidelines; Process; Research; Ruthenium Ben; Self-Help Devices; Social Functioning; Speech; Speech Perception; Structure; Synapses; Testing; Trauma; Work; auditory pathway; base; behavior measurement; cell type; cholinergic; congenital deafness; design; emerging adult; functional decline; hearing impairment; improved; prevent; programs; public health relevance; relating to nervous system; response; sound; synaptic function

DESCRIPTION (provided by applicant): Hearing loss impairs speech perception and loudness perception, which can have negative effects on academic achievement, cognition, and social functioning. Many aspects of deteriorated hearing performance, such as listening to speech in a complex acoustic background, cannot be explained solely on the basis of peripheral damage. Performance on these tasks is likely affected by neural reorganization or deterioration in the central auditory pathway. The long-term goal of our research program is to investigate how acquired hearing loss affects synaptic organization of the auditory system, how these synaptic changes relate to behavioral changes in hearing, and whether or not the synaptic abnormalities can be recovered or prevented. It is important that we investigate the impact of different forms of hearing loss on the brain to understand variable perceptual deficits and unpredictable outcomes after hearing intervention. This grant will support functional and anatomical investigations in mice with noise-induced hearing damage. Mice will be exposed to moderate noise that has been historically characterized as safe and to moderately loud noise known to cause permanent hearing loss. We will measure behavioral changes in temporal processing and loudness perception and investigate the corresponding changes in structure and organization of neural inputs to specific cell types in the ventral cochlear nucleus. These studies will provide important information for understanding complex hearing deficits and may have implications for improving treatment of hearing loss and for noise trauma prevention guidelines.

描述（由申请人提供）：听力损失会损害言语感知和响度感知，这可能对学业成绩、认知和社会功能产生负面影响。听力性能下降的许多方面，例如在复杂的声学背景下听语音，不能仅用周围损伤来解释。这些任务的表现可能会受到神经重组或中枢听觉通路恶化的影响。我们研究计划的长期目标是调查获得性听力损失如何影响听觉系统的突触组织，这些突触变化如何与听力行为变化相关，以及突触异常是否可以恢复或预防。重要的是我们要调查不同形式的影响 大脑听力损失，以了解听力干预后可变的知觉缺陷和不可预测的结果。这笔拨款将支持对噪音引起的听力损伤的小鼠进行功能和解剖学研究。小鼠将暴露于历史上被认为是安全的中等噪音和已知会导致永久性听力损失的中等大声噪音中。我们将测量时间处理和响度感知的行为变化，并研究腹侧耳蜗核中特定细胞类型的神经输入的结构和组织的相应变化。这些研究将提供重要的 了解复杂听力缺陷的信息，可能对改善听力损失的治疗和噪声创伤预防指南产生影响。