Biomechanical Basis of Pediatric mTBI Due to Sports Related Concussion

运动相关脑震荡引起的小儿 mTBI 的生物力学基础

• 批准号: 8851208
• 负责人: Stefan Duma
• 金额: $ 71.22万
• 依托单位: VIRGINIA POLYTECHNIC INST AND ST UNIV
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-03-15 至 2020-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8851208
• 关键词: Acceleration; Adult; Age; Athletic; Biomechanics; Biomedical Engineering; Brain; Brain Concussion; Brain Injuries; Childhood; Clinical; Clinical Data; Data; Data Collection; Databases; Detection; Development; Devices; Diagnosis; Diagnostic; Environment; Equipment; Evaluation; Exposure to; Freedom; General Population; Goals; Head; Health; Healthcare; Helmet; Incidence; Injury; Knowledge; Logistic Regressions; Manufactured football; Measurement; Measures; Methods; Modeling; Outcome; Pilot Projects; Play; Population; Practice Guidelines; Prevention; Prevention strategy; Preventive Intervention; Recording of previous events; Relative (related person); Research; Risk; Seasons; Severities; Signs and Symptoms; Site; Sports; System; Technology; Telemetry; Testing; Therapeutic; Translational Research; United States; United States National Institutes of Health; Validation; Vehicle crash; Work; Youth; aged; base; biomechanical model; cognitive change; cohort; college; consumer product; design; experience; head impact; improved; in vivo; instrument; member; mild traumatic brain injury; novel; novel strategies; outcome forecast; prevention evaluation; public health relevance; research and development; tool

 DESCRIPTION (provided by applicant): We propose to develop a quantitative model of the biomechanical basis of mild traumatic brain injury (MTBI) for a pediatric population. This expands upon our initial five year Bioengineering Research Partnership (BRP) in which we developed a biomechanical model of MTBI for a collegiate population, which has resulted in a database of more than 500,000 recorded head impacts in collegiate sports. This work has produced substantial advancements in the knowledge of injury mechanisms and head impact exposure, and resulted in translational outcomes, including: 1) adult brain injury criteria that provide improved diagnosis strategies and prevention systems, 2) optimized helmet design criteria and publically available helmet evaluations that have improved helmet technologies, and 3) football practice guidelines that have reduced head impact exposure in collegiate football. The proposed pediatric MTBI model will enable translational research and the development of new clinical and therapeutic approaches to reduce the incidence and negative effects of MTBI in youth athletes. Experimental and clinical projects among our team members will allow us to test hypotheses specific to the underlying pathomechanics and clinical sequelae of pediatric MTBI. A cohort of 1050 youth football players between the ages of 6 and 14 years will wear instrumented helmets to collect head acceleration data and clinical data over a 5 year period. Athletic environments offer a rich opportunity for collecting data on large numbers of head impacts, which enables research that combines biomechanical head impact data with the subsequent neurobiologic and functional changes in the brain. To date, biomechanical MTBI research has focused primarily on the approximately 100,000 athletes participating in college and professional football in the United States; however, little is known about the 3,500,000 youth (6 years to 14 years) athletes playing football each year. We hypothesize that head acceleration due to impact is predictive of the type and severity of brain injury, and correlates t specific clinical measures of pediatric MTBI. We aim to: 1) Quantify head impact exposure in youth football, 2) Determine head acceleration injury tolerance for sustaining pediatric MTBI, and 3) Correlate head acceleration with clinical variables related to pediatric MTBI. We have performed a pilot study on 119 youth football players aged 7 to 18 years to demonstrate the feasibility of the proposed work. Successful completion of the proposed hypothesis-driven research will result in the development of novel protective equipment strategies, diagnostic tools for field use and other healthcare settings, novel strategies for return to play decisions, and educational tools for disseminating information about the evaluation and prevention of MTBI in the pediatric population. Additionally, our research results will have translational relevance to the general population, including motor vehicle crashes and pediatric consumer products.

 描述（由适用提供）：我们建议针对小儿种群开发一种针对轻度创伤性脑损伤（MTBI）的生物力学基础的定量模型。这扩展了我们最初的五年生物工程研究合作伙伴关系（BRP），在该伙伴关系中，我们为大学人口开发了MTBI的生物力学模型，这导致了一个数据库，该数据库在大学体育运动中有超过500,000个记录的头部影响。这项工作在了解伤害机制和头部影响暴露的知识方面取得了长足的进步，并导致了转化结果，包括：1）成人脑损伤标准，这些标准可提供改进的诊断策略和预防系统，2）优化的头盔设计标准以及具有改进的头盔技术的公开头盔评估，以及橄榄球练习的橄榄球练习型驾驶效果不佳。拟议的小儿MTBI模型将实现转化研究以及开发新的临床和治疗方法，以减少MTBI在青年运动员中的发病率和负面影响。我们团队成员之间的实验和临床项目将使我们能够测试针对小儿MTBI的基本病理学和临床后遗症的假设。在6至14岁之间的1050名青年足球运动员组成的队列将戴上仪器头盔，以在5年内收集头部加速数据和临床数据。运动环境为收集有关大量头部影响的数据提供了丰富的机会，这可以使生物力学头部影响数据与随后的神经生物学和大脑功能变化结合起来。迄今为止，生物力学MTBI研究主要集中在美国参加美国大学和职业足球的大约100,000个学科。但是，对于每年踢足球的3,500,000名青年（6年至14岁）的年轻人知之甚少。我们假设由于影响而引起的头部加速度可以预测脑损伤的类型和严重程度，并将小儿MTBI的特定临床测量与T。我们的目标是：1）量化青年足球的头部撞击暴露，2）确定持续儿科MTBI的头部加速损伤耐受性，3）与与儿科MTBI相关的临床变量相关联的头部加速度。我们已经对7至18岁的119名青年足球运动员进行了试点研究，以证明拟议工作的可行性。成功完成拟议的假设驱动的研究将导致开发新颖的保护设备策略，现场使用诊断工具和其他医疗保健设置，新的返回决策策略以及用于传播有关儿科人群MTBI评估和预防信息的教育工具。此外，我们的研究结果将转化为一般人群的相关性，包括汽车撞车和小儿消费产品。