Impact of progestin contraception on risk of HIV acquisition and transmission

孕激素避孕对艾滋病毒感染和传播风险的影响

基本信息

  • 批准号:
    8836564
  • 负责人:
  • 金额:
    $ 12.7万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2014
  • 资助国家:
    美国
  • 起止时间:
    2014-04-10 至 2019-03-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION: This proposal outlines a 5-year career development plan and research strategy that enables me to bolster my background in OB-GYN/family planning with additional skills and proficiency in translational research in reproductive infectious diseases and to conduct a proof of concept study to explore the mechanisms underlying the risk of HIV acquisition associated with hormonal contraception. Career Development Plan: Having completed a 2-year fellowship in family planning with in-depth training on contraception and a Master of Public Health degree, I possess a basic foundation in clinical research methodology. Expanding on this foundation, the current proposal integrates aspects of basic medical sciences relevant to reproductive health with advanced coursework. Three major areas are emphasized: 1) Multidisciplinary mentorship; 2) Didactic training in virology, immunology, and advanced clinical research methodology; and 3) Hands-on laboratory training in relevant basic science techniques. The team of mentors includes Dr. Igho Ofotokun, an NIH-funded investigator with vast experience in women's health research in HIV infection and Dr. Denise Jamieson, an adjunct professor at Emory and Chief of the Women's Health and Fertility Branch, Division of Reproductive Health at the Centers for Disease Control (CDC). My long-term goal is to become an independent clinician scientist in the field of reproductive infectious diseases with a focus on safe family planning in high-risk populations. The supportive environment offered by Emory University, the Center for AIDS Research, and the Atlanta Clinical Translational Science Institute, in addition to the collaborative relationship with CDC will foster my career development. Research Plan: I propose to develop my translational research experience around a proof of concept prospective cohort design. Focusing on HIV negative women, the 3 proposed aims will evaluate the effect of depot medroxyprogesterone acetate (DMPA), Etonogestrel impant (Eng-Implant) and Levonorgestrel intrauterine device (Lng-IUD) exposure on 1) HIV target immune cells within the female genital mucosa; 2) markers of T-cell activation and trafficking within the female genital mucosa; and 3) secreted cytokines and chemokines within the female genital mucosa. A prospectively recruited cohort of HIV negative women will allow the examination of the overarching hypothesis that alterations in HIV target immune cells and function within the female genital mucosa underlie the relatively higher HIV risk associated with the pharmacologic doses of exogenous sex hormones, Because the anticipated mucosal immune changes with progestin-only contraceptives are to a large extent mediated via estrogen suppression, the impact of Eng-Implant and Lng- IUD (with milder anti-estrogen effect) is expected to be significantly less pronounced compared with that of DMPA. The outcomes of the proposed study could have significant clinical implications for the provision of family planning services fo women worldwide.
描述:该提案概述了一项为期5年的职业发展计划和研究策略,使我能够以其他技能和精通生殖传染病的转化研究来支持我的OB-GYN/计划生育背景。探索与激素避孕有关的HIV获取风险的基础机制。 职业发展计划:完成了为期2年的计划生育奖学金,并在避孕方面进行了深入的培训和公共卫生硕士学位,因此我拥有临床研究方法的基本基础。为了扩展该基金会,当前的提案将与生殖健康相关的基本医学科学的各个方面与高级课程相关。强调三个主要领域:1)多学科指导; 2)病毒学,免疫学和晚期临床研究方法的教学培训; 3)相关基础科学技术实验室培训。导师团队包括NIH资助的研究员Igho Ofotokun博士,在艾滋病毒感染方面拥有丰富的妇女健康研究经验,埃默里(Emory)的兼职教授兼妇女健康与生育分公司的兼职教授丹妮丝·贾米森(Denise Jamieson)博士,生殖健康部门在疾病控制中心(CDC)。我的长期目标是成为生殖传染病领域的独立临床医生,重点是在高危人群中安全的计划生育。除了协作关系外,埃默里大学,艾滋病研究中心和亚特兰大临床转化科学研究所提供了支持环境 使用CDC将促进我的职业发展。 研究计划:我建议围绕概念的前瞻性队列设计发展我的翻译研究经验。专注于艾滋病毒负面女性,提出的3个目标将评估乙酸盐丙酮(DMPA)(DMPA),Etonogestrel Invant(Eng-Implant)(Eng-Implant)和左旋癌症内部装置(LNG-IUD)暴露于1)女性HIV靶标细胞对1)HIV靶靶细胞的影响。粘膜; 2)女性生殖器粘膜内T细胞激活和运输的标记; 3)女性生殖器粘膜内的分泌细胞因子和趋化因子。前瞻性招募的艾滋病毒负面妇女队列将允许研究总体假设,即艾滋病毒靶标细胞的改变并在女性生殖器粘膜中起作用,这是与外源性激素的药理剂量相对较高的艾滋病毒风险,因为预期的粘膜是预期的粘膜剂量仅孕激素避孕药的免疫变化在很大程度上是通过雌激素抑制介导的,与DMPA相比,Eng-Implant和LNG-IUD(具有温和的抗雌激素效应)的影响明显不那么明显。拟议的研究的结果可能会对全球妇女提供的计划生育服务具有重大临床影响。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
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Lisa Blake Haddad其他文献

Lisa Blake Haddad的其他文献

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{{ truncateString('Lisa Blake Haddad', 18)}}的其他基金

Contraception development research center to advance a novel intravaginal ring as a non-hormonal multipurpose prevention technology
避孕开发研究中心将开发新型阴道环作为非激素多用途预防技术
  • 批准号:
    10324914
  • 财政年份:
    2021
  • 资助金额:
    $ 12.7万
  • 项目类别:
Population Council Contraception Development Research Center Administrative Core
人口委员会避孕发展研究中心行政核心
  • 批准号:
    10324915
  • 财政年份:
    2021
  • 资助金额:
    $ 12.7万
  • 项目类别:
Contraception development research center to advance a novel intravaginal ring as a non-hormonal multipurpose prevention technology
避孕开发研究中心将开发新型阴道环作为非激素多用途预防技术
  • 批准号:
    10493305
  • 财政年份:
    2021
  • 资助金额:
    $ 12.7万
  • 项目类别:
Population Council Contraception Development Research Center Administrative Core
人口委员会避孕发展研究中心行政核心
  • 批准号:
    10493310
  • 财政年份:
    2021
  • 资助金额:
    $ 12.7万
  • 项目类别:
Population Council Contraception Development Research Center Administrative Core
人口委员会避孕发展研究中心行政核心
  • 批准号:
    10700066
  • 财政年份:
    2021
  • 资助金额:
    $ 12.7万
  • 项目类别:
Contraception development research center to advance a novel intravaginal ring as a non-hormonal multipurpose prevention technology
避孕开发研究中心将开发新型阴道环作为非激素多用途预防技术
  • 批准号:
    10700065
  • 财政年份:
    2021
  • 资助金额:
    $ 12.7万
  • 项目类别:
Emory Specialized Center of Research Excellence (SCORE) on Sex Differences
埃默里大学性别差异专业卓越研究中心 (SCORE)
  • 批准号:
    9790907
  • 财政年份:
    2018
  • 资助金额:
    $ 12.7万
  • 项目类别:
Immunologic changes associated with three progestin-based contraceptives: characterizing immune profiles over one year and identifying factors that may alter HIV risk
与三种孕激素避孕药相关的免疫学变化:描述一年内的免疫特征并确定可能改变艾滋病毒风险的因素
  • 批准号:
    10201695
  • 财政年份:
    2018
  • 资助金额:
    $ 12.7万
  • 项目类别:
Immunologic changes associated with three progestin-based contraceptives: characterizing immune profiles over one year and identifying factors that may alter HIV risk
与三种孕激素避孕药相关的免疫学变化:描述一年内的免疫特征并确定可能改变艾滋病毒风险的因素
  • 批准号:
    9754233
  • 财政年份:
    2018
  • 资助金额:
    $ 12.7万
  • 项目类别:
Immunologic changes associated with three progestin-based contraceptives: characterizing immune profiles over one year and identifying factors that may alter HIV risk
与三种孕激素避孕药相关的免疫学变化:描述一年内的免疫特征并确定可能改变艾滋病毒风险的因素
  • 批准号:
    10440378
  • 财政年份:
    2018
  • 资助金额:
    $ 12.7万
  • 项目类别:

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Defining Sex-Specific Systemic and Gut Inflammatory Profiles in People Living with HIV
定义艾滋病毒感染者的性别特异性全身和肠道炎症特征
  • 批准号:
    10619980
  • 财政年份:
    2023
  • 资助金额:
    $ 12.7万
  • 项目类别:
Influence of fetal antiretroviral exposure on gut microbiota, systemic inflammation and neurodevelopment in infants exposed to HIV
胎儿抗逆转录病毒暴露对暴露于 HIV 的婴儿的肠道微生物群、全身炎症和神经发育的影响
  • 批准号:
    10617395
  • 财政年份:
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  • 资助金额:
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Changes in Enteric Microbiota and Inflammation with HIV PrEP
HIV PrEP 引起的肠道微生物群变化和炎症
  • 批准号:
    10700595
  • 财政年份:
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隐球菌性脑膜脑炎期间平衡免疫反应的机制
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TFAM 改变在 HIV 和 ART 诱导的大脑线粒体功能障碍中的作用
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