Prostate Cancer Parasitism of the HSC "niche" as a Molecular Mechanism for Ost

前列腺癌 HSC“生态位”的寄生作为 Ost 的分子机制

• 批准号: 8464645
• 负责人: RUSSELL S TAICHMAN
• 金额: $ 20.72万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-06-05 至 2014-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8464645
• 关键词: ANXA2 gene; Accounting; Adhesions; Angiogenic Switch; Animals; Antibodies; Area; Binding; Biological Assay; Biology; Bone Marrow; Bone Marrow Transplantation; CXC Chemokines; CXCR4 Receptors; CXCR4 gene; Data; Endothelial Cells; Engraftment; Event; Foundations; Funding; Growth; Hematopoietic stem cells; Home environment; Homing; Homing Behavior; Implant; Indium; Invaded; Investigation; Ligands; Location; Malignant Neoplasms; Malignant neoplasm of prostate; Marrow; Metastatic Neoplasm to the Bone; Metastatic Prostate Cancer; Modeling; Molecular; Neoplasm Metastasis; Osteoblasts; Pathway interactions; Peptides; Play; Primary Neoplasm; Prostate; Receptor Signaling; Role; Route; Signal Pathway; Signal Transduction; Skeleton; Stromal Cell-Derived Factor 1; Testing; Therapeutic Intervention; Time; Tissues; Work; bone; cell growth; foot; in vivo; metastatic process; neoplastic cell; novel; parasitism; prostate cancer cell; receptor; stem cell niche; tumor

In our previous P01 project we examined the relationship between the expression of CXCR4 by metastatic prostate cancers (PCa) and their bone homing behavior. From these studies we acquired data that suggest that not only do PCa's use the CXCR4/SDF-1 pathway to home to bone - but there is a strong likelihood they use the hematopoietic stem cell (HSC)

在我们之前的 P01 项目中，我们研究了转移性前列腺癌 (PCa) 的 CXCR4 表达与其骨归巢行为之间的关系。从这些研究中，我们获得的数据表明 PCa 不仅使用 CXCR4/SDF-1 途径归入骨骼，而且很可能使用造血干细胞 (HSC)