Gene-Environment Interactinos Training Program

基因-环境相互作用培训计划

• 批准号: 8889398
• 负责人: Alvaro Puga
• 金额: $ 25.64万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-07-01 至 2015-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8889398
• 关键词: Environment; Genes; Training Programs

The goal of the Gene-Environment Interactions Training Program (GEITP) is to train pre-doctoral and postdoctoral students who will be versed in ways that both environment exposures and genetic diversity nteract to alter the onset of disease. Achieving this objective requires an interdisciplinary team approach integrating an understanding of genetic diversity, epigenetic alterations, high-throughput genomics, biostatistics, biomarkers, and exposure assessment approaches. The collaborative efforts of research faculty, clinicians, postdoctoral and pre-doctoral trainees are needed in order to meet this objective. A mentorship team approach, combining the expertise of well-regarded scientists in the areas of exposure assessment, genetic variability, biomarkers of disease, and individualized/tailored medicine will be used to educate trainees in multiple areas of gene-environment interactions. Predoctoral training will include required coursework in addition to the student's matriculated Ph.D. program, laboratory rotations with the team of mentors, and hands-on work in several areas of exposure assessment, high-throughput genetic variability measures, and biomarkers or exposure and/or disease. Postdoctoral training will include programs in laboratory and personnel management, pilot grant applications, and an intensive year long grant writing workshop to prepare them for independent research. All trainees will be required to attend "Technologies in genomics, exposure, and biomarkers" workshop, which will be created as part of this program, and present research results at an annual GEITP Student Symposium. This program will include a dedicated governance structure to assure that appropriate trainees are recruited, education goals are met, and the aims of this grant are achieved.

基因环境互动培训计划（GEITP）的目标是培训博士前和 博士后学生将以环境暴露和遗传多样性的方式精通 改变疾病的发作。实现这一目标需要跨学科的团队方法 整合对遗传多样性，表观遗传改变，高通量基因组学的理解， 生物统计学，生物标志物和暴露评估方法。研究的协作努力 为了满足这一目标，需要教师，临床医生，博士后和博士前学员。一个 指导团队方法，结合了良好的科学家的专业知识 评估，遗传变异性，疾病的生物标志物以及个性化/量身定制的药物将用于 在基因环境相互作用的多个领域进行教育。专业培训将包括 除了学生的入学博士学位外，还需要课程。程序，实验室轮换 导师团队和在多个暴露评估领域的动手工作，高通量遗传 可变性度量，生物标志物或暴露和/或疾病。博士后培训将包括 实验室和人员管理，试点赠款申请以及密集的一年赠款计划 编写研讨会，为他们准备独立研究。所有学员都必须参加 “基因组学，曝光和生物标志物的技术”研讨会，该研讨会将作为其中的一部分创建 计划，并在年度GEITP学生研讨会上进行研究结果。该程序将包括一个 专门的治理结构以确保招募适当的学员，实现教育目标， 并实现了这笔赠款的目标。

项目成果

Cutting Edge: CLEC5A Mediates Macrophage Function and Chronic Obstructive Pulmonary Disease Pathologies.

• DOI: 10.4049/jimmunol.1500978
• 发表时间: 2016-04-15
• 期刊: Journal of immunology (Baltimore, Md. : 1950)
• 作者: Wortham BW;Eppert BL;Flury JL;Garcia SM;Donica WR;Osterburg A;Joyce-Shaikh B;Cua DJ;Borchers MT
• 通讯作者: Borchers MT