Childhood health disparities: exploration of prenatal exposures in primary teeth

儿童期健康差异：乳牙产前暴露的探索

• 批准号: 8429805
• 负责人: Andrea E Cassidy-Bushrow
• 金额: $ 25.36万
• 依托单位: HENRY FORD HEALTH SYSTEM
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-12-01 至 2014-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8429805
• 关键词: 2 year old; Ablation; Accounting; Adult; Age; Allergic; Allergic Disease; Area; Arsenic; Asthma; Barker Hypothesis; Birth; Birth Weight; Cadmium; Child; Child health care; Childhood; Chronic Disease; County; Coupled; Data; Development; Early identification; Early treatment; Environment; Fetal Development; Fetus; Future; Geographic Locations; Gestational Age; Goals; Health; Health Policy; Health system; Human; Hypersensitivity; Image; Immune system; Industry; Lasers; Lead; Life; Longitudinal Studies; Manganese; Maps; Mass Spectrum Analysis; Measures; Mercury; Metal exposure; Metals; Methods; Minority; Outcome; Participant; Phenotype; Plant Roots; Plasma; Pollution; Predisposition; Premature Birth; Prevention strategy; Public Health; Race; Recruitment Activity; Reliance; Research Personnel; Role; Sampling; Socioeconomic Status; Source; Time; Tooth structure; Toxic Environmental Substances; Toxicant exposure; Woman; atopy; body system; cohort; deciduous tooth; early childhood; early life exposure; fetal; fetal lead exposure; health disparity; high risk; improved; interest; metropolitan; novel; novel strategies; postnatal; prenatal; prenatal exposure; prenatal risk factor; public health relevance; racial difference; segregation; social; socioeconomics; suburb; theories; toxicant; trait

DESCRIPTION (provided by investigator): Differences in prenatal exposures may account for some of the racial disparities observed in health outcomes; however, studies have been hampered by a lack of a reliable means of examining such retrospective exposures. A novel method, elemental bio-imaging of human primary teeth with laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS), will be used to measure metal exposures in naturally sheed teeth of an established birth cohort. This approach not only quantifies exposure but also estimates the timing of the exposure (i.e. within trimester). We hypothesize there are identifiable critical windows of exposure aligned with gestational development of key organ systems that are specific for different child health outcomes. The proposed project builds on extant data collected through the racially and socioeconomically diverse Wayne County Health, Environment, Allergy and Asthma Longitudinal Study (WHEALS) birth cohort conducted between 2003 and 2007 in Detroit, MI and the surrounding suburban regions. From a subset of active WHEALS participants, 250 naturally shed primary teeth (230 unique children) will be collected and 5 metals (lead, cadmium, manganese, mercury, arsenic) will be measured with LA-ICP-MS. Our outcomes of interest are two traits demonstrating substantial racial disparities: birth weight and allergic disease measures at age 2 years. Our aims are to (1) examine if there are racial differences in early-life metal toxicant exposures; (2) examine if trimester-specific exposures to metal toxicants are associated with birth weight; and (3) examine if early-life exposures to metal toxicants are associated with allergic disease at age 2. Information gained by the proposed study may guide public health policy, improve prevention strategies, and lead to earlier identification and treatment of high-risk children with the overall goal to reduce health disparitis and improve the publics' heath.

描述（由研究者提供）：产前暴露的差异可能是造成健康结果中观察到的一些种族差异的原因；然而，由于缺乏可靠的手段来检查此类回顾性暴露，研究受到了阻碍。一种新方法，即利用激光烧蚀-电感耦合等离子体质谱法（LA-ICP-MS）对人类乳牙进行元素生物成像，将用于测量已确定的出生队列中自然脱落的牙齿中的金属暴露量。这种方法不仅可以量化暴露，还可以估计暴露的时间（即三个月内）。我们假设有可识别的 关键暴露窗口与针对不同儿童健康结果的关键器官系统的妊娠发育相一致。该拟议项目以 2003 年至 2007 年间在密歇根州底特律及周边郊区进行的种族和社会经济多元化韦恩县健康、环境、过敏和哮喘纵向研究 (WHEALS) 出生队列收集的现有数据为基础。从活跃的 WHEALS 参与者中，将收集 250 颗自然脱落的乳牙（230 名独特的儿童），并使用 LA-ICP-MS 测量 5 种金属（铅、镉、锰、汞、砷）。我们感兴趣的结果是两个表现出巨大种族差异的特征：出生体重和 2 岁时过敏性疾病的测量结果。我们的目标是（1）检查生命早期金属毒物暴露是否存在种族差异； (2) 检查妊娠期特定的金属毒物暴露是否与出生体重相关； (3) 检查生命早期接触金属毒物是否与 2 岁时的过敏性疾病有关。拟议研究获得的信息可以指导公共卫生政策，改进预防策略，并导致更早识别和治疗高危儿童总体目标是缩小健康差距，提高公众健康水平。