Prenatal Sex Steroids, Bisphenol A, Phthalates, and Sexually Dimorphic Behaviors

产前性类固醇、双酚 A、邻苯二甲酸盐和性别二态行为

• 批准号: 8587520
• 负责人: Joseph M Braun
• 金额: $ 20.1万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-02-14 至 2016-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8587520
• 关键词: 8 year old; 9 year old; Address; Affect; Aggressive behavior; Amniotic Fluid; Androgens; Androstenedione; Animals; Archives; Area; Attention deficit hyperactivity disorder; Attenuated; Autistic Disorder; Award; Behavior; Behavioral; Biological; Biological Markers; Birth; Boston; Brain; Chemicals; Child; Childhood; Clinical; Data; Disease; Endocrine Disruptors; Endocrine system; Endocrinology; Environment; Epidemiologist; Epidemiology; Estradiol; Estrogens; Estrone; Exposure to; Female; Fetal Development; Gonadal Steroid Hormones; Health; Human; Individual; Infant; Institution; Instruction; Intervention; Knowledge; Learning; Learning Disabilities; Measures; Meconium; Mediating; Medical; Memory; Mental Depression; Mentors; Mentorship; Methods; Nature; Outcome; Outcome Measure; Pathway interactions; Performance; Perinatal Exposure; Phase; Play; Population; Pregnancy; Pregnant Women; Process; Psychometrics; Public Health; Radial; Reproductive Health; Research; Research Personnel; Research Project Grants; Research Training; Resources; Risk; Rodent; Role; Sampling; Sex Characteristics; Short-Term Memory; Testing; Testosterone; Time; Toxicant exposure; Training; Umbilical Cord Blood; United States; Urine; Validation; Visuospatial; Work; abstracting; analog; arm; bisphenol A; career; cohort; computerized; critical period; environmental chemical; environmental chemical exposure; experience; fetal; improved; male; morris water maze; multidisciplinary; neurobehavior; neurobehavioral; neurobehavioral disorder; neurobehavioral test; neurodevelopment; neurotoxicity; novel; performance tests; phthalates; prenatal; prospective; public health relevance; sex; skills; symposium; urinary; virtual

Abstract: The fetal brain is uniquely sensitive and environmental chemical exposures and dysregulation of the endocrine system may increase the risk of adverse neurobehavioral outcomes like autism, attention-deficit/hyperactivity disorder, or depression. Under the mentorship of Drs. Bellinger and Hauser, this training and research plan will build upon Dr. Braun's expertise as an environmental epidemiologist and prepare him for a career studying endocrine disrupting compounds (EDCs) and their impact on hormonal systems and childhood neurodevelopment. Dr. Braun has never received formal training in these areas and few researchers possess this unique cross-disciplinary expertise. During the K99-phase of this award Dr. Braun will use tutorials, seminars/conferences, and didactic instruction to gain additional training in: 1) endocrinology concepts and the impact of environmental chemicals on the endocrine system; 2) psychometric test selection, administration, validation, and interpretation; and 3) childhood neurodevelopment. This training will be applied in an original research project where Dr. Braun will administer computerized tests of visuospatial ability to 25 children from Dr. Hauser's Environment and Reproductive Health (EARTH) study under the guidance of both Drs. Hauser and Bellinger. These computerized tests are analogues of the Morris Water Maze and Radial Arm Maze, which are used in animal studies of neurotoxicity. Using these new skills and the prospective Health Outcomes and Measures of the Environment (HOME) birth cohort, Dr. Braun will address two specific aims during the R00- phase of this award: 1) determine if gestational BPA/phthalate exposure is associated with visuospatial ability in 300 children and if sex modifies these associations and 2) determine if gestational BPA/phthalate exposure is associated with meconium sex steroid concentrations in 330 infants. Dr. Braun is well suited to carry out this research because of his prior training and the unique resources offered by his mentors, advisors, and institution. This proposed training and research will enable him to study the impact of EDCs on other hormonal systems and whether they increase the risk of adverse childhood behavioral outcomes. The examination of sex steroids will advance our knowledge of potential biological mechanisms of EDC action and the use of neurobehavioral tests with animal analogues will improve comparisons between epidemiological and animal studies.

抽象的： 胎儿大脑对环境化学物质暴露和内分泌失调非常敏感 系统可能会增加不良神经行为结果的风险，如自闭症、注意力缺陷/多动症 障碍，或抑郁症。在博士的指导下。贝林格和豪瑟，这个培训和研究计划将 以布劳恩博士作为环境流行病学家的专业知识为基础，为他的职业学习做好准备 内分泌干​​扰化合物 (EDC) 及其对荷尔蒙系统和儿童的影响 神经发育。布劳恩博士从未接受过这些领域的正式培训，而且很少有研究人员拥有这些培训 这种独特的跨学科专业知识。在该奖项的 K99 阶段，Braun 博士将使用教程， 研讨会/会议和教学指导，以获得以下方面的额外培训：1) 内分泌学概念和 环境化学物质对内分泌系统的影响； 2) 心理测试的选择、管理、 验证和解释； 3）儿童神经发育。本次培训将应用于原创 在该研究项目中，布劳恩博士将对 25 名来自不同国家的儿童进行计算机化视觉空间能力测试。 豪瑟博士在两位博士的指导下进行了环境与生殖健康（EARTH）研究。豪瑟 和贝林格。这些计算机化测试类似于莫里斯水迷宫和径向臂迷宫， 用于神经毒性的动物研究。利用这些新技能和预期的健康成果 布劳恩博士将在 R00 期间解决环境措施 (HOME) 出生群体的两个具体目标 该奖项的阶段：1) 确定妊娠期 BPA/邻苯二甲酸盐暴露是否与视觉空间能力相关 在 300 名儿童中进行研究，确定性别是否改变了这些关联；2) 确定妊娠期 BPA/邻苯二甲酸盐暴露是否 与 330 名婴儿胎便性类固醇浓度有关。布劳恩博士非常适合开展这项工作 由于他之前的培训以及他的导师、顾问和 机构。这项拟议的培训和研究将使他能够研究 EDC 对其他激素的影响 系统以及它们是否会增加不良儿童行为结果的风险。性别检查 类固醇将增进我们对 EDC 作用的潜在生物学机制和使用的了解 使用动物类似物进行神经行为测试将改善流行病学和动物之间的比较 研究。