IGF::OT::IGF - B599 SPECIAL STUDIES/ANALYSIS- OTHER

IGF::OT::IGF - B599 特别研究/分析 - 其他

• 批准号: 9173473
• 负责人: SOREN GERMER
• 金额: $ 1346.81万
• 依托单位: NEW YORK GENOME CENTER
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-25 至 2016-09-24
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9173473
• 关键词: African; Asthma; Atrial Fibrillation; Behavioral; Bioinformatics; Biological Process; Biotechnology; Blood; Chronic Obstructive Airway Disease; Clinical; Clinical Data; Communities; Complex; Data; Data Coordinating Center; Diagnosis; Disease; Dyslipidemias; Ensure; European; Funding; Genetic Markers; Genetic Transcription; Genomics; Goals; Health; Heart; Hispanics; Image; Individual; Informatics; Lung; Medicine; Metabolic; Molecular; National Heart, Lung, and Blood Institute; Obesity; Outcome; Pacific Island Americans; Participant; Pattern; Phase; Phenotype; Population; Population Heterogeneity; Precision Medicine Initiative; Prevention; Proteomics; Research; Resources; Sleep Apnea Syndromes; Sleep Disorders; System; disorder risk; disorder subtype; genome sequencing; improved; metabolomics; novel; personalized medicine; precision medicine; programs; protein expression; repository; trait

Trans-Omics for Precision Medicine (TOPMed) is an NHLBI-wide initiative to generate scientific resources to enhance our understanding of fundamental biological processes that underlie HLBS disorders through the integration of –omics (e.g., genomic, proteomic, metabolomic) and phenotypic data in an effort to improve the prediction, prevention, diagnosis, and treatment of these disorders. To support the NHLBI TOPMed program, the Whole-Genome Sequencing (WGS) project will collect whole-genome sequencing data from individuals with well characterized phenotypes and existing clinical outcome data. This project aims to identify genetic markers of increased or decreased risk of disease, as well as those that help define disease subtypes. The initial phase of the WGS project has identified nearly 20,000 participants from previous NHLBI-funded studies to undergo whole-genome sequencing. This first set of participants includes individuals that have complex traits (e.g., dyslipidemia) and the following heart, lung, blood and sleep (HLBS) disorders: Atrial fibrillation, Asthma, Chronic obstructive pulmonary disease (COPD), Obesity,and Sleep apnea. The objective is to establish a novel genomic resource that is reflective of the diversity of the US population. Almost half of current study participants are of European descent, with the remainder being people of African, Hispanic and Pacific Islander ancestry. Currently, the WGS project is being conducted by nine participating research centers, four sequencing centers, an informatics research center, and a Data Coordinating Center (DCC). As the project progresses, it is anticipated that other centers will join the consortium. The National Center for Biotechnology will provide archival and bioinformatics support.

精确医学的跨词（TopMed）是一项NHLBI范围的计划，旨在生成科学资源，以增强我们对基本生物学过程的理解，这些过程通过–omics的整合（例如基因组，蛋白质组学，代谢瘤）和对预测，预测，预测，诊断和诊断来改善这些诊断，这些诊断，这些过程（例如，基因组，蛋白质组学，代谢瘤）和表型数据，这些诊断，这些诊断，这些过程（例如，基因组，蛋白质组学，代谢瘤）和表型数据，这些诊断，这些诊断。为了支持NHLBI顶级程序，全基因组测序（WGS）项目将从具有良好表征表型和现有临床结果数据的个体中收集全基因组测序数据。该项目旨在确定疾病风险增加或降低的遗传标志物以及有助于定义疾病亚型的遗传标志物。 WGS项目的初始阶段已经确定了从先前由NHLBI资助的研究中进行全基因组测序的近20,000名参与者。第一组参与者包括具有复杂特征（例如血脂异常）和以下心脏，肺，血液和睡眠（HLBS）疾病的个体：心房颤动，哮喘，慢性阻塞性肺疾病（COPD），肥胖和睡眠呼吸暂停。目的是建立一种反映美国人口多样性的新型基因组资源。目前几乎一半的研究参与者是欧洲血统，其余的是非洲，西班牙裔和太平洋岛民血统的人。目前，WGS项目由9个参与研究中心，四个测序中心，一个信息研究中心和数据协调中心（DCC）进行。随着项目的进行，预计其他中心将加入财团。国家生物技术中心将提供档案和生物信息学支持。