Parvin Building Animal Resources Center Improvement Plan

帕尔文大楼动物资源中心改进计划

• 批准号: 8525901
• 负责人: RICHARD W ERMEL
• 金额: $ 48.06万
• 依托单位: BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-05-01 至 2014-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8525901
• 关键词: AIDS-Related Lymphoma; Accreditation; Achievement; Activities of Daily Living; Address; Animal Experimentation; Animal Housing; Animal Model; Animal Welfare; Animals; Antineoplastic Agents; Area; Avastin; Biomedical Research; Biotechnology; Breeding; Capital; Caring; Censuses; Cities; Clinical Services; Clinical Trials; Collaborations; Comprehensive Cancer Center; Development; Diabetes Mellitus; Disease; Division of Clinical Sciences; Duct (organ) structure; Ensure; Equipment; Extramural Activities; FDA approved; Faculty; Funding; Future; Genetic Engineering; Growth; Heart; Housing; Human; IACUC; Indoor Air Quality; Institution; Insulin; International; Laboratory Animals; Leadership; Life; Link; Los Angeles; Malignant Neoplasms; Malignant neoplasm of lung; Medical; Medicine; Minor; Modification; Molecular Genetics; Monoclonal Antibodies; Mus; National Cancer Institute; Phase; Prevention; Principal Investigator; Process; Protocols documentation; RNA Interference; Recording of previous events; Research; Research Activity; Research Infrastructure; Research Institute; Research Personnel; Research Project Grants; Resources; Roche brand of rituximab; Roche brand of trastuzumab; Rodent; Science; Services; Strategic Planning; System; Translational Research; United States Department of Agriculture; United States National Institutes of Health; Water; animal care; animal facility; animal resource; base; cigarette smoking; comparative; density; design; diabetic; exhaust; falls; improved; innovation; meetings; novel therapeutics; pre-clinical research; preclinical study; programs

DESCRIPTION (provided by applicant): The Parvin Building Animal Resources Center Improvement Plan will significantly increase the animal holding capacity for animal models used in breeding and research activities at the Beckman Research Institute of City of Hope (COH/BRI) and will substantially optimize space utilization at the Division of Comparative Medicine within the centralized Animal Resources Center (ARC) animal facility. Over the past decade, COH/BRI has grown both in research staff (25%) and extramural funding (120%) through the direction of a purposeful, strategic plan to increase biomedical research in the areas of novel therapeutics for catastrophic diseases- mainly cancer and diabetes. This increase in funding has been accompanied by an increase in the number of IACUC-approved animal use protocols (from 118 to 230), and the average daily animal census has increased more than five-fold. As a result, the ARC has recently reached its functional operational capacity, and is facing a critical juncture, challenged with providing enough space and enhanced services to meet the current needs of animal-based research programs (short-term), as well as to plan for continued growth (long-term). COH/BRI has identified animal facility improvement and expansion as a strategic necessity, and is in the process of designing an expansion to the facility. Although the institution has moved forward with minor renovations and equipment acquisition, animal housing currently available is only able to meet current needs, and cannot accommodate new projects or our anticipated future growth in pre-clinical and translational research programs involving animal models. Unless the current ARC animal holding space shortage is addressed, potential disruptions, delays or curtailment of animal model-based research projects may occur. Therefore, the requested space efficient, high density, ventilated rodent housing systems and associated equipment are urgently needed to maintain and further develop our innovative institutional biomedical and translational research programs, while also facilitating new research initiatives, by increasing the animal facility holding capacity and improving operational efficiencies. The requested high density animal housing systems will be used to replace older, less space efficient, ventilated housing systems in two mouse breeding rooms in the animal facility. This will allow the ARC to optimize space utilization in the current facility, and after he facility expansion, while also increasing efficiencies in labor and energy and improving indoor air quality. The requested equipment will support the successful completion of 78 ($23.5M) active and 122 ($35.3M) pending projects involving animal model research, and will help to ensure COH/BRI continues its remarkable history of innovation and achievements in science and medical care.

描述（由申请人提供）：帕尔文大楼动物资源中心改进计划将显着增加希望城贝克曼研究所 (COH/BRI) 用于育种和研究活动的动物模型的动物容纳能力，并将大幅优化空间集中动物资源中心 (ARC) 动物设施内比较医学部的利用。在过去的十年中，COH/BRI 通过有目的的战略计划的指导，增加了研究人员 (25%) 和外部资金 (120%) 的增长，以增加灾难性疾病（主要是癌症）新疗法领域的生物医学研究和糖尿病。资金的增加伴随着 IACUC 批准的动物使用协议数量的增加（从 118 个增加到 230 个），平均每日动物普查增加了五倍以上。因此，ARC 最近已达到其功能运作能力，并面临着一个关键时刻，面临着提供足够空间和增强服务的挑战，以满足当前基于动物的研究计划（短期）的需求，以及持续增长计划（长期）。 COH/BRI 已将动物设施的改进和扩建确定为战略必要性，并且正在设计该设施的扩建。尽管该机构已经进行了小规模整修和设备采购，但目前可用的动物房只能满足当前的需求，无法容纳新项目或我们预期的涉及动物模型的临床前和转化研究项目的未来增长。除非当前 ARC 动物饲养空间短缺的问题得到解决，否则基于动物模型的研究项目可能会发生潜在的中断、延误或缩减。因此，迫切需要所需的空间高效、高密度、通风的啮齿动物饲养系统和相关设备，以维持和进一步发展我们的创新机构生物医学和转化研究项目，同时通过增加动物设施的容纳能力和改进，促进新的研究举措运营效率。所要求的高密度动物饲养系统将用于取代动物设施中两个小鼠饲养室中旧的、空间效率较低的通风饲养系统。这将使 ARC 能够优化当前设施以及设施扩建后的空间利用率，同时提高劳动力和能源效率并改善室内空气 质量。所请求的设备将支持成功完成 78 个（2,350 万美元）涉及动物模型研究的活跃项目和 122 个（3,530 万美元）待决项目，并将有助于确保 COH/BRI 继续其在科学和医疗保健领域的创新和成就的辉煌历史。