Console Electronics Upgrade for 11.7T MRI System

11.7T MRI 系统控制台电子设备升级

• 批准号: 8448370
• 负责人: CHIEN HO
• 金额: $ 56.45万
• 依托单位: CARNEGIE-MELLON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-06-15 至 2014-12-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8448370
• 关键词: Amplifiers; Animal Model; Area; Biomedical Research; Cardiology; Cell Nucleus; Cells; Communities; Computer software; Craniocerebral Trauma; Disabled Persons; Electronics; Equipment; Funding; Generations; Graft Rejection; Hour; Housing; Human Resources; Image; Immunology; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Malignant Neoplasms; Manufacturer Name; Minor; Organ; Organ Transplantation; Psychiatry; Request for Applications; Research; Research Infrastructure; Research Project Grants; Running; S10 grant; Scheme; System; Technology; Tissues; United States National Institutes of Health; Universities; biomedical resource; handicapping condition; imaging modality; instrument; instrumentation; tool

DESCRIPTION (provided by applicant): In this S10 application, we are requesting funds to purchase a Bruker Avance III electronics console upgrade and accessories for an existing 11.7T/8.9cm vertical-bore micro imaging system. The existing instrument was installed in 2001 and funded in part by an NIH shared instrumentation grant (S10 RR15704). This magnet system has proved to be invaluable to the Pittsburgh NMR Center for Biomedical Research and runs over 100 hours a week. However, we now have an overwhelming and urgent need to replace the electronics console, software, and accessories because: (1) the major electronics systems, including items such as the gradient controller, RF/gradient amplifiers, digitizers, etc., are now three-generations behind current technologies. These components cannot run the most modern image acquisition schemes, and replacement parts will soon become unavailable, (2) the manufacturer (Bruker) no longer supports imaging software upgrades for our outdated console electronics. Without software upgrades, we are handicapped in our ability to apply new and emerging imaging methods that benefit our users, and (3) key hardware components have already failed, such as our X-nuclei high-power RF amplifier, or on the verge of failing, such as our gradient coil and several RF resonators. The existing 11.7T instrument is housed at the Pittsburgh NMR Center for Biomedical Research at Carnegie Mellon University. The NMR Center has been continuously funded as a Biomedical Resource Center by the NIH (P41 EB-001977) since 1988. The NMR Center is dedicated to advancing state-of-the-art applications MRI and magnetic resonance spectroscopy (MRS) to understand tissue and organ function using animal models and making these tools available to the larger biomedical research community. The NMR Center already has in place personnel and an extensive infrastructure to operate and maintain the instrument. The availability of upgraded MRI instrumentation will serve a large number of NIH-supported research projects across diverse areas of biomedical research, including cell tracking, immunology, psychiatry, cardiology, organ transplant rejection, cancer, head trauma, and cellular therapy. Overall, the proposed equipment upgrade is critical for maintaining the 11.7T instrument as a state-of-the-art system to support ongoing research for 5 Major and 12 Minor users.

描述（由申请人提供）：在此 S10 申请中，我们请求资金购买布鲁克 Avance III 电子控制台升级以及现有 11.7T/8.9cm 垂直孔径显微成像系统的配件。现有仪器于 2001 年安装，部分资金由 NIH 共享仪器补助金 (S10 RR15704) 资助。事实证明，该磁体系统对于匹兹堡 NMR 生物医学研究中心来说非常宝贵，每周运行 100 多个小时。然而，我们现在迫切需要更换电子控制台、软件和配件，因为：(1) 主要电子系统，包括梯度控制器、射频/梯度放大器、数字化仪等，现在都已更换。落后当前技术三代。这些组件无法运行最现代的图像采集方案，并且替换部件很快就会变得不可用，(2) 制造商 (布鲁克) 不再支持我们过时的控制台电子设备的成像软件升级。如果没有软件升级，我们就无法应用新的和新兴的成像方法来造福我们的用户，并且 (3) 关键硬件组件已经出现故障，例如我们的 X 核高功率射频放大器，或者濒临失效。失败，例如我们的梯度线圈和几个射频谐振器。现有的 11.7T 仪器位于卡内基梅隆大学匹兹堡生物医学研究核磁共振中心。自 1988 年以来，NMR 中心作为生物医学资源中心一直受到 NIH (P41 EB-001977) 的资助。NMR 中心致力于推进最先进的应用 MRI 和磁共振波谱 (MRS) 来了解组织使用动物模型来研究和器官功能，并使这些工具可供更大的生物医学研究界使用。核磁共振中心已经配备了人员和广泛的基础设施来操作和维护仪器。升级版 MRI 仪器的推出将为 NIH 支持的大量生物医学研究不同领域的研究项目提供服务，包括细胞追踪、免疫学、精神病学、心脏病学、器官移植排斥、癌症、头部创伤和细胞治疗。总体而言，拟议的设备升级对于维持 11.7T 仪器作为最先进的系统以支持 5 个主要用户和 12 个次要用户正在进行的研究至关重要。