1 of 2 - Prospective Determination of Psychobiological Risk Factors for PTSD

1 of 2 - PTSD 心理生物学风险因素的前瞻性确定

基本信息

批准号：
8659508
负责人：
CHARLES B NEMEROFF
金额：
$ 35.05万
依托单位：
UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-05-17 至 2017-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8659508
关键词：
Accident and Emergency department Accidents Acute Address Adult Algorithms Biological Biological Factors Biological Markers Biological Models Blood Brain-Derived Neurotrophic Factor Candidate Disease Gene Cessation of life Child Abuse Chronic Chronic Post Traumatic Stress Disorder Classification Clinical Clinical Research Clinical Services Collection Coupled Crime Cross-Sectional Studies DNA DNA Markers Data Data Collection Data Set Development Diagnosis Disasters Disease Dissociation Doctor of Medicine Doctor of Philosophy Earthquakes Enrollment Environmental Risk Factor Epidemiologic Studies Epigenetic Process Event Exhibits Exposure to Family Family Study Female Forcible intercourse Gender Gene Expression Gene Expression Profile Genes Genetic Genetic Polymorphism Genetic Transcription Genomics Goals HTR3A gene Healthcare Systems Heritability Hospitals Hurricane Image Individual Injury Intervention Life Link Maps Measurement Measures Medical Mental disorders Methods Methylation Microarray Analysis Minority Modeling Morbidity - disease rate Natural Disasters Oils Outcome Pathogenesis Patients Phenotype Population Post-Traumatic Stress Disorders Prevalence Prevention Prospective Studies RGS2 gene RNA Reading Recruitment Activity Research Risk Risk Factors Running Sampling Seminal Series Severities Site Social support Statistical Models Survivors Symptoms Techniques Terrorism Trauma Tsunami Twin Studies United States Universities Validation Variant Violence War abuse neglect automobile accident base biosignature cohort combat disorder risk experience follow-up gene function genetic analysis genetic risk factor genome wide association study genome-wide inclusion criteria inner city instrument man meetings mortality novel predictive modeling prospective psychobiologic psychologic psychopharmacologic psychosocial research study resilience risk variant statistics tool transcriptomics trauma centers

项目摘要

DESCRIPTION (provided by applicant): Post-traumatic Stress Disorder (PTSD) is one of the most highly prevalent psychiatric disorders and its prevalence is likely increasing in the United States and worldwide due to the rising numbers of natural disasters (earthquakes, hurricanes, tsunamis), man-made disasters (oil spills), terrorism and wars, as well as violent crime and automobile accidents. Although the majority of trauma victims experience the cardinal symptoms of re-experiencing, avoidance and hyperarousal, for the large majority of such individuals, these symptoms do not become chronic nor do they develop syndromal PTSD. It is important to identify the large minority of trauma victims with a high likelihood of developing PTSD because of the very significant medical and psychiatric morbidity and mortality associated with this disorder. There is already considerable evidence that the likelihood of developing PTSD after trauma exposure is due to a combination of genetic and environmental factors. This two-site, linked R-01 application seeks to utilize state-of-the art advances in genomics, transcriptomics and epigenetics, coupled with comprehensive clinical and psychological measures, to address this seminal unanswered question in PTSD clinical service and research. To achieve this goal, 500 trauma-exposed subjects will be recruited at the University of Miami Ryder Trauma Center and the Emory University affiliated Grady Memorial Hospital and followed at regular intervals for one year. This focused, hypothesis-driven study will scrutinize previously identified psychological and biological risk factors. Genetic risk factors include polymorphisms of the ADCYAP1R1, FKBP5, DAT, BDNF, COMT, CRFR1, 5HTTLPR, RGS2, GABA2 and 5HT3R genes, novel genetic and epigenetic risk factors and most importantly, the primary downstream effects of these genomic and epigenetic findings by the use of conventional and newer statistical modeling methods. These findings should provide the means to identify trauma survivors who will likely develop PTSD and can therefore be referred for appropriate psychotherapeutic and/or psychopharmacologic treatment. Such a strategy has the potential to help redefine psychobiological subtypes of PTSD as well as to reduce the burden of chronic PTSD on our healthcare system.

描述（由申请人提供）：创伤后应激障碍（PTSD）是最普遍的精神疾病之一，由于自然灾害的数量增加（地震，飓风，Tsunamis，Tsunamis），Mandassers Accills（油性），恐怖主义和恐怖主义以及犯罪和犯罪和犯罪，以及恐怖主义和恐怖症和犯罪，其危机和全世界的普遍性可能正在增加和全球范围内增加。尽管大多数创伤受害者经历了重新体验，避免和高音的基本症状，但对于大多数此类人来说，这些症状并没有变得慢性，也不会发展综合症PTSD。由于与这种疾病相关的非常重要的医学和精神病发病率和死亡率非常重要，因此重要的是要确定少数有可能发展为PTSD的创伤受害者。已经有大量证据表明，创伤暴露后开发PTSD的可能性是由于遗传和环境因素的结合。这项链接的R-01应用程序旨在利用基因组学，转录组学和表观遗传学方面的最先进的进步，再加上全面的临床和心理措施，以解决PTSD临床服务和研究中的这个精确的未解决问题。为了实现这一目标，将在迈阿密莱德大学创伤中心和埃默里大学附属的Grady Memorial Hospital招募500名受创伤的受试者，并定期进行一年。这项集中的，假设驱动的研究将先前仔细检查确定的心理和生物学危险因素。遗传危险因素包括ADCYAP1R1，FKBP5，DAT，BDNF，COMT，CRFR1，5HTTTLPR，RGS2，RGS2，GABA2和5HT3R基因的多态性，新型遗传和表观遗传风险，最重要的是，这些统计量和新的统计方法的主要下降效果和新的统计方法和新的统计方法和新的统计效果。这些发现应提供一种方法来识别可能会发展PTSD的创伤幸存者，因此可以转诊以进行适当的心理治疗和/或心理药物治疗。这种策略有可能帮助重新定义PTSD的心理生物学亚型，并减轻慢性PTSD在我们的医疗保健系统上的负担。