The Eighth International Mdm2 Workshop

第八届国际Mdm2研讨会

基本信息

批准号：
9022188
负责人：
Hua Lu
金额：
$ 0.78万
依托单位：
TULANE UNIVERSITY OF LOUISIANA
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-09-22 至 2016-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9022188
关键词：
Address Antineoplastic Agents Area Award Basic Science Binding Biology Cancer Center Cities Collaborations Communities Complement Development Doctor of Medicine Doctor of Philosophy Educational workshop Embryonic Development Ensure Europe Event Funding Future Gene Amplification Human Individual International Louisiana MDM2 gene Malignant Neoplasms Medical Students Mentors Minority Missense Mutation New York Pathway interactions Play Protein p53 Public Health Reagent Recruitment Activity Reporting Research Research Personnel Role Scientist Senior Scientist Site Staging Students TP53 gene Time Translational Research Travel Tumor Suppressor Proteins Underrepresented Minority United Kingdom United States Universities Woman Writing abstracting career college drug discovery graduate student in vivo inhibitor/antagonist interdisciplinary approach medical schools meetings member mouse model novel overexpression posters public health relevance social symposium tumor ubiquitin-protein ligase

项目摘要

DESCRIPTION (provided by applicant): Project Summary/Abstract The p53 protein has been well characterized as playing a tumor suppressor role in human cancer. Indeed, a majority of human tumors have sustained missense mutation in the TP53 gene. Mdm2 is a major negative regulator of p53 that has been shown to act by inhibiting the transcriptional activity of p53 via direct binding as well as serving as an E3 ubiquitin ligase to target p53 for degradation. Consistent with such findings, Mdm2 has been demonstrated as also playing a role in human tumors with its overexpression or gene amplification being observed in a variety of cancers. The scientific need for the 8th International MDM2 Workshop arises from the central role that the p53 tumor suppressor and its negative regulator Mdm2 have regarding the development and progression of human cancer and the promise that the p53-Mdm2 interaction holds for development of novel therapies. The expansion of the scientific community studying Mdm2 and the need to pursue this area of research with a collaborative multidisciplinary approach has further made it necessary to have Mdm2 Workshops. Thus, while both the p53 and Mdm2 Workshops started as small gatherings of researchers in the field, they have become necessary for future progress. A p53 Workshop is held every two years to bring together the p53 field in order to report on the latest research and to facilitate collaboration and exchange of reagents. The first p53 Workshop was held in 1983 in the United Kingdom. Fourteen years ago, the first complementing Mdm2 Workshop was held in alternating years with the p53 conference. The Workshops have since been held every two years, alternating between Europe and the United States. The 8th International MDM2 Workshop will be held at Tulane University School of Medicine on November 1-4th, 2015. The meeting is being co-organized by Hua Lu (Tulane University) and Wei Gu (Columbia University). The site of the conference is in the Bowers Auditorium, 1555 Poydras Street, New Orleans, Louisiana. Tulane University is a major long-term leasee of the 1555 Poydras building. This Auditorium hosts research seminars and medical student classes for the Tulane Community. Therefore, we are applying for the R13 fund to support this highest level and exciting international meeting in this field, which would dramatically re-energize the research and promote scientific interactions and exchanges in the area.

描述（由申请人提供）：项目摘要/摘要 p53 蛋白已被充分表征为在人类癌症中发挥肿瘤抑制作用。事实上，大多数人类肿瘤的 TP53 基因都存在持续错义突变，Mdm2 是主要的负调节因子。 p53 已被证明通过直接结合抑制 p53 的转录活性以及作为 E3 泛素连接酶靶向 p53 进行降解。有了这些发现，Mdm2 已被证明在人类肿瘤中也发挥着作用，在多种癌症中观察到其过度表达或基因扩增。第八届国际 MDM2 研讨会的科学需求源于 p53 肿瘤抑制因子和 p53 肿瘤抑制因子的核心作用。其负调节因子 Mdm2 与人类癌症的发生和进展有关，并且 p53-Mdm2 相互作用对开发新疗法具有前景。科学界研究 Mdm2 的扩展以及追求的必要性。这一采用多学科协作方法的研究领域进一步使得 Mdm2 研讨会变得必要。因此，虽然 p53 和 Mdm2 研讨会都是该领域研究人员的小型聚会，但它们已成为未来进展的必要条件。研讨会每两年举办一次，汇集 p53 领域的最新研究成果并促进试剂的合作和交流。第一届 p53 研讨会于 14 年在英国举行。此前，第一届 MDM2 研讨会与 p53 会议每隔几年举行一次。此后，该研讨会每两年在欧洲和美国轮流举办。第八届国际 MDM2 研讨会将于 2019 年在杜兰大学医学院举行。 2015年11月1-4日，会议由卢华（杜兰大学）和谷伟（哥伦比亚大学）共同主办，会议地点在Bowers。礼堂，1555 Poydras Street，新奥尔良，路易斯安那大学是 1555 Poydras 大楼的主要长期承租人，该礼堂为杜兰社区举办研究研讨会和医学生课程。支持这一领域这一最高水平和令人兴奋的国际会议，这将极大地重新激发该领域的研究并促进科学互动和交流。