2013 Molecular Pharmacology Gordon Research Conference and Gordon Research Semina

2013年分子药理学戈登研究会议暨戈登研究研讨会

基本信息

批准号：
8520657
负责人：
Joann Trejo
金额：
$ 2.5万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-04-24 至 2014-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8520657
关键词：
Address Animal Model Animals Applied Research Area Basic Science Biological Models Biology Biosensor Cardiovascular system Clinical Sciences Clinical Trials Communicable Diseases Complex Development Disease Drug Targeting Drug abuse Endocrine Europe Fertilization Fostering G-Protein-Coupled Receptors Goals International Italy Ligands Light Link Malignant Neoplasms Marketing Medicine Mental disorders Methodology Minority Groups Molecular Obesity Orphan Outcome Pharmaceutical Preparations Pharmacology Physiology Postdoctoral Fellow Process Receptor Signaling Research Research Personnel Scientist Signal Transduction Signaling Protein Techniques Therapeutic Work doctoral student drug development human disease in vivo innovation meetings nervous system disorder novel novel strategies novel therapeutics programs public health relevance receptor receptor function single molecule symposium

项目摘要

DESCRIPTION (provided by applicant): The Molecular Pharmacology Gordon Research Conference (GRC) is a key forum gathering scientists from basic, applied and clinical science in G protein coupled receptor (GPCR) research. Here we request partial support for the 2013 conference, 24th GRC edition, which will include both the GRC and the recently adjoined Gordon Conference Research Seminar (GRS). Specific aims of GRC/GRS 2013 seek to attract the very best scientists from academic and industrial worlds to discuss major developments in the field, encourage open discussions on latest and also controversial ideas in the field, facilitae collaborative work in areas of translational opportunities, and serve as a highly effective forum for doctoral students, post-docs and junior scientists to share their results and interact with mor senior colleagues. The Molecular Pharmacology GRC traditionally alternates between US and Europe, and the GRC/GRS 2013 will be held in Tuscany (Il Ciocco, Italy). The conference will emphasize both emerging and rapidly growing areas in the field. Innovation in the 2013 program includes a strong emphasis on mechanisms relevant to physiology, discussion on unusual GPCRs or model systems, and the presentation of cutting-edge methodologies addressing single molecules to animal biology and human diseases. Specifically the program will cover four main areas: i) structural dynamics of receptors and receptor complexes including studies at the single molecule level, ii) ligand-biased signaling in cellular and in vivo, and novel approaches to physiology with an emphasis on animal models, (iii) novel opportunities for drug development and therapeutics, including the identification of GPCRs linked to human diseases and (iv) orphan and atypical GPCRs, revealing new mode of action of these important signaling proteins. Methodological aspects will include novel physical and computing approaches, the development of innovative biosensors and light-controlled processes, and novel therapeutic strategies. The conference will gather about 150 speakers and attendees and the anticipated outcome is cross-fertilization of ideas and techniques, towards enhanced understanding of GPCR biology and associated diseases.

描述（由申请人提供）：分子药理学戈登研究会议 (GRC) 是一个重要论坛，聚集了来自 G 蛋白偶联受体 (GPCR) 研究领域的基础科学、应用科学和临床科学的科学家。在此，我们请求为 2013 年第 24 届 GRC 会议提供部分支持，其中包括 GRC 和最近举行的戈登会议研究研讨会 (GRS)。 GRC/GRS 2013 的具体目标是吸引学术界和工业界最优秀的科学家来讨论该领域的重大发展，鼓励对该领域最新的和有争议的想法进行公开讨论，促进转化机会领域的合作工作，以及为博士生、博士后和初级科学家提供一个高效的论坛，分享他们的成果并与高级同事互动。分子药理学GRC传统上在美国和欧洲轮流举行，GRC/GRS 2013将在托斯卡纳（意大利Il Ciocco）举行。会议将重点关注该领域的新兴和快速增长领域。 2013 年项目的创新包括重点强调与生理学相关的机制、对不寻常 GPCR 或模型系统的讨论，以及针对动物生物学和人类疾病的单分子前沿方法的介绍。具体来说，该计划将涵盖四个主要领域：i）受体和受体复合物的结构动力学，包括单分子水平的研究，ii）细胞和体内配体偏向信号传导，以及新方法生理学，重点是动物模型，(iii) 药物开发和治疗的新机遇，包括鉴定与人类疾病相关的 GPCR，以及 (iv) 孤儿和非典型 GPCR，揭示这些重要信号蛋白的新作用模式。方法论方面将包括新颖的物理和计算方法、创新生物传感器和光控过程的开发以及新颖的治疗策略。会议将聚集约 150 名演讲者和与会者，预期成果是思想和技术的交叉融合，以加深对 GPCR 生物学和相关疾病的理解。