Efficacy of brisk walking as a smoking cessation treatment adjunct among women

快走作为女性戒烟治疗辅助手段的功效

• 批准号: 8433992
• 负责人: David M Williams
• 金额: $ 39.63万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-02-01 至 2016-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8433992
• 关键词: Abstinence; Adherence; Adult; Affect; Affective; Aftercare; Attenuated; Behavior; Cause of Death; Cognitive; Cotinine; Counseling; Data Sources; Disease; Effectiveness; Electronics; Environment; Exercise; Female; Future; Health Benefit; Incentives; Jogging; Mental Depression; Monitor; Moods; Morbidity - disease rate; Nicotine Withdrawal; Outcome; Participant; Physical Fitness; Pilot Projects; Plague; Prevalence; Process; Protocols documentation; Public Health; Randomized; Randomized Controlled Trials; Relapse; Relative (related person); Research; Running; Saliva; Sample Size; Site; Smoker; Smoking; Smoking Cessation Intervention; Smoking Status; Techniques; Testing; Time; Treatment outcome; Walking; Weight; Weight Gain; Wellness Program; Withdrawal Symptom; Withholding Treatment; Woman; base; cigarette smoking; compliance behavior; cost; design; diaries; efficacy testing; follow-up; improved; mortality; nicotine patch; post intervention; programs; psychosocial; public health relevance; sedentary; smoking cessation; treatment effect; treatment program

DESCRIPTION (provided by applicant): Cigarette smoking is the leading, preventable cause of morbidity and mortality among women; however, approximately 18 percent of women continue to smoke cigarettes. Mood-related withdrawal symptoms and concerns about weight-gain are significant barriers to successful smoking cessation, especially among women. Moderate intensity exercise (e.g., brisk walking) is a safe and low-cost adjunct to standard smoking cessation treatments that may aid in the smoking cessation process by improving mood and attenuating weight concerns during smoking cessation. Previous RCTs examining moderate intensity exercise as a smoking cessation treatment have been plagued by poor compliance with the exercise program, lack of adequate control conditions, and lack of objective monitoring of exercise behavior and smoking cessation outcomes. Thus, we propose an RCT (N = 164) to test the efficacy of moderate intensity exercise (150 min/week) as an adjunct to a standard 12-week smoking cessation treatment (i.e., brief one-time baseline counseling plus the nicotine patch) among healthy, previously inactive adult female smokers. Consistent with our recently completed pilot study (R03 CA119747), a number of techniques will be used to enhance internal validity and thus overcome the weaknesses of previous trials, including: (a) use of a wellness comparison condition that equates for staff contact time; (b) direct observation of all exercise and wellness sessions; (b) use of monetary incentives to increase compliance with the exercise/wellness programs; and (c) multiple objective assessments of smoking status (CO monitoring and saliva cotinine analysis) during the 12-week treatment and during a 6-month follow- up period. Additionally, we will explore affective withdrawal symptoms and weight concerns as potential mechanisms of the exercise treatment in real-time and in participants natural environments via ecological momentary assessment. The proposed study will provide a definitive test of the efficacy of moderate intensity exercise as an adjunct to standard smoking cessation treatment. If initial efficacy can be established, then further research will be warranted to test more disseminable moderate intensity exercise programs to establish effectiveness in real-world conditions (i.e., enhancing adherence to exercise programs in the absence of monetary incentives). Regardless of treatment outcomes, the proposed EMA protocol will provide a rich source of data to conduct a detailed examination of the determinants of smoking lapses and relapse over time and how these determinants are impacted by exercise behavior. This will further our understanding of successful smoking cessation versus relapse and aid in the design of future smoking cessation interventions.

描述（由申请人提供）：吸烟是导致女性发病和死亡的首要且可预防的原因；然而，大约 18% 的女性继续吸烟。与情绪相关的戒断症状和对体重增加的担忧是成功戒烟的重大障碍，尤其是对女性而言。中等强度的运动（例如快走）是标准戒烟治疗的一种安全且低成本的辅助手段，可以通过在戒烟期间改善情绪和减轻体重问题来帮助戒烟过程。之前的随机对照试验研究了中等强度运动作为戒烟治疗的方法，但由于运动计划依从性差、缺乏足够的控制条件以及缺乏对运动行为和戒烟结果的客观监测而受到困扰。因此，我们提出一项随机对照试验（N = 164）来测试中等强度运动（150 分钟/周）作为标准 12 周戒烟治疗（即简短的一次性基线咨询加尼古丁贴片）的辅助手段的功效。 ）在健康、以前不活动的成年女性吸烟者中。与我们最近完成的试点研究（R03 CA119747）一致，将使用多种技术来增强内部效度，从而克服先前试验的弱点，包括：（a）使用相当于工作人员接触时间的健康比较条件； (b) 直接观察所有锻炼和健康课程； (b) 使用金钱奖励来提高对锻炼/健康计划的遵守情况； (c) 在 12 周治疗期间和 6 个月随访期间对吸烟状况进行多重客观评估（CO 监测和唾液可替宁分析）。此外，我们将通过生态瞬时评估，在参与者的自然环境中实时探索情感戒断症状和体重问题作为运动治疗的潜在机制。拟议的研究将对中等强度运动作为标准戒烟治疗的辅助手段的功效提供明确的测试。如果可以确定初步效果，则需要进一步研究来测试更多可传播的中等强度锻炼计划，以确定现实条件下的有效性（即在没有金钱激励的情况下增强对锻炼计划的坚持）。无论治疗结果如何，拟议的 EMA 方案都将提供丰富的数据源，以详细检查戒烟和随时间复吸的决定因素以及这些决定因素如何受到运动行为的影响。这将进一步加深我们对成功戒烟与复发的理解，并有助于设计未来的戒烟干预措施。