HVAC Improvements to Expand Research Capabilities at Colorado State University

改进暖通空调以扩大科罗拉多州立大学的研究能力

• 批准号: 8712862
• 负责人: Lon Vern Kendall
• 金额: $ 35.6万
• 依托单位: COLORADO STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-05-07 至 2018-03-05
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8712862
• 关键词: Address; Air; Air Pressure; Animal Model; Animals; Automation; Biomedical Research; Censuses; Colorado; Communicable Diseases; Development; Extramural Activities; Faculty; Felis catus; Funding; Grant; Health; Housing; Human; Humidity; Immunology; Maintenance; Malignant Neoplasms; Mechanics; Microbiology; Mus; Pathology; Principal Investigator; Prions; Procedures; Recruitment Activity; Request for Proposals; Research; Research Personnel; Savings; Science; Services; Specific Pathogen Frees; System; Temperature; Universities; Update; Veterinary Medicine; animal facility; biosecurity; college; exhaust; germ free condition; member; pressure; rapid growth

Project Abstract. This proposal requests funds to acquire an updated air handling unit (AHU) sized approximately 13,500 cfm to maintain proper temperature and air pressure differentials with humidity, building automation system, and exhaust fans replacing a >25 year old unit that is no longer serviceable for the Pathology vivarium at Colorado State University. The Pathology viviarium currently houses CSU's specific pathogen free (SPF) cat colony and a modest number of mouse cages used in prion research. This upgrade provides us the opportunity to vastly expand our housing capabilities and animal procedure space within our existing animal facilities. Specifically, the animal model core of the Prion Research Center (PRC) will be consolidated into the Pathology vivarium along with the SPF cat colony. The PRC currently has animals held in both the main animal holding facility, the Painter Center, and the Pathology vivarium. Over the past three years, the PRC has seen a 4-fold increase in animal census. This rapid growth has put constraints on the Painter Center holding capabilities. However, we have been reluctant to relocate animals to the available space in the Pathology vivarium due to mechanical concerns over the current air handling unit. There have been over 40 service calls the past two years to CSU Facilities Management to address concerns such as inability to maintain the appropriate temperature, inability to maintain appropriate airflow, and inability to maintain appropriate pressure differentials for biosecurity of the SPF cat colony and biocontainment for prion studies; and a mechanical assessment identified numerous concerns. Upgrading the AHU would provide stable environmental controls to appropriately house additional animals. Consolidating the PRC animal model core to the Pathology vivarium will more than double their existing housing and manipulation space. Furthermore, it will vacate space in the Painter Center which could be repurposed. There are currently only two procedure rooms outside of biocontainment for investigator use. By moving the prion users to the Pathology vivarium we can dedicate an additional three rooms to procedure space, as well as create additional animal holding space for current, new faculty recruits. This proposal will benefit all of the 53 principal investigators from12 academic departments with over $154M in current extramural grant support, including five faculty members from the PRC ($16.5M in current total funding). Because of the University's focus on infectious disease, cancer, and other biomedical research initiatives, this project will enhance a large portfolio of studies conducted to benefit animal and human health. Consistent with a strong record of support for development and maintenance of state of the art animal facilities, the Vice President for Research, the Dean of the College of Veterinary Medicine and Biomedical Sciences, the Chair of the Department of Microbiology, Immunology and Pathology have all enthusiastically supported this proposal. A modern AHU will also provide substantial energy savings. Construction will be managed with consideration for sustainable concepts directed by a LEED Accredited Facilities Professional Project Manager.

项目摘要。该提案要求资金购买更新的空中处理单元（AHU） 尺寸约13,500 cfm，以保持适当的温度和气压差速器 湿度，建筑自动化系统和排气风扇取代了一个> 25年的单元 科罗拉多州立大学的病理学不再可用。病理 Viviarium目前容纳CSU的特定病原体（SPF）猫菌群和一个适中的数字 用于prion研究中的小鼠笼子。此升级为我们提供了极大的机会 扩大我们现有动物设施内的住房能力和动物程序空间。 具体而言，Prion研究中心（PRC）的动物模型核心将合并到 病理学与SPF猫菌落一起。中国目前有动物 主要动物持有设施，画家中心和病理学。在 过去三年，中国的动物普查增加了4倍。这种快速增长有 在画家中心持有功能上放置约束。但是，我们不愿意 由于机械关注 在当前的空气处理单元上。在过去的两年中，已经有40多个服务电话 CSU设施管理以解决诸如无法维护适当的问题 温度，无法保持适当的气流以及无法保持适当的 SPF CAT菌落生物可观的压力差​​异和生物植物的生物生物差异； 机械评估确定了许多问题。升级AHU将提供 稳定的环境控制可适当容纳其他动物。合并中国 病理学的动物模型核心将使其现​​有住房和 操纵空间。此外，它将在画家中心腾出空间 重新利用。目前，在生物内部设备之外只有两个程序室 研究者使用。通过将prion用户转移到病理学中，我们可以专门 其他三个房间可以进行程序空间，并为 当前的新教师新兵。该提案将使所有53名主要调查人员受益 从122个学术部门拥有超过1.54亿美元的现有校外赠款支持，包括 中国的五名教职员工（目前的总资金为1650万美元）。因为 大学专注于传染病，癌症和其他生物医学研究计划， 项目将增强大量研究，以使动物和人类健康受益。 与对制定和维护最新状态的支持的强烈记录一致 动物设施，研究副校长，兽医学院院长 医学和生物医学科学，免疫学系主席 病理学都热情地支持了这一建议。现代AHU也会 提供大量节能。施工将被考虑考虑 由LEED认可的设施专业项目经理指导的可持续概念。