Evaluation of iNOS Antagonists in the Prevention of Oral Cancer - HHSN261201200

iNOS 拮抗剂预防口腔癌的评价 - HHSN261201200

• 批准号: 8760480
• 负责人: Michael Pawlita
• 金额: $ 62.13万
• 依托单位: IIT RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-18 至 2015-09-17
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8760480
• 关键词: Animals; Chemopreventive Agent; Chronic; Dose; Evaluation; Goals; Malignant Neoplasms; Maximum Tolerated Dose; Pharmacodynamics; Pre-Clinical Model; Rodent Model; Schedule; Testing; Tissues; cancer chemoprevention; efficacy testing; inhibitor/antagonist; malignant mouth neoplasm; oral cancer prevention

The primary goal of this task order is to determine whether iNOS inhibitors, as exemplified by compounds representative of this mechanistic class, have cancer chemopreventive efficacy in preclinical models of oral cancer.

该任务顺序的主要目标是确定 iNOS 抑制剂（以此类机制的代表化合物为代表）是否在口腔癌临床前模型中具有癌症化学预防功效。