Epidemiology of lens aging in older women

老年女性晶状体老化的流行病学

基本信息

批准号：
8403655
负责人：
JASON Leigh SANDERS
金额：
$ 4.72万
依托单位：
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-01-01 至 2013-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8403655
关键词：
Accidents Adult Advanced Glycosylation End Products Age Aging Aging-Related Process Animal Model Atherosclerosis Benchmarking Biological Process Blood Brain Caloric Restriction Cardiovascular Diseases Cataract Cell Aging Chronic Chronic Disease Cohort Studies Communities Coronary Arteriosclerosis Crystallins DNA Dehydroepiandrosterone Sulfate Densitometry Development Devices Diabetes Mellitus Digit structure Disease Disease Marker Elderly Epidemiologic Studies Epidemiology Evaluation Excision Family Fetal Development Functional disorder Future Gait Goals Health Heart Homeostasis Hormonal Human Individual Inflammation Insulin Insulin-Like Growth Factor I Interleukin-6 Intervention Studies Investigation Length Lens Diseases Lens Opacities Leukocytes Life Maintenance Measures Metabolic Metabolic Marker Molecular Molecular Chaperones Morbidity - disease rate Mortality Decline Names Onset of illness Optics Outcome Oxidative Stress Participant Performance Perimenopause Phenotype Photography Physical Function Population Postmenopause Preventive Intervention Process Protein Conformation Proteins Research Research Personnel Research Training Risk Factors Skeletal Muscle Skin Speed Stress System Testing Tissues Vascular Diseases Whole Organism Woman Work age effect aging population base candidate marker cognitive function cohort disability experience fasting glucose fasting plasma glucose functional decline genetic manipulation human population study in vivo interest lens lens protein lens transparency molecular marker mortality muscle strength novel older women public health relevance repaired telomere young adult

项目摘要

DESCRIPTION (provided by applicant): It is critical to determine how we age if we hope to optimize the wellbeing of individuals, particularly older adults who represent a growing proportion of the population. Traditionally, studying aging was equated with unalterable decline and the development of disease. Although it is uncertain if the primary effects of aging can be fully distinguished from the secondary effects of disease, recent research has identified that aging and disease are not synonymous, and subsequently that aging can be optimized. This has been most clearly demonstrated in animal models with genetic manipulation and caloric restriction. In these systems mortality rate has been the primary marker of aging, but for human studies in vivo markers of aging are needed. Few primary markers of aging have been validated in human population studies. Aging of the lens, as assessed using lens transparency, has been proposed as a reflection of aging because it is detectable in early to mid adulthood and can be distinguished from known diseases of the lens, including specific types of cataract. The goal of this epidemiologic study is to determine the association of lens transparency with measures of disease and measures of aging in a cohort of older women. These will include atherosclerosis, a marker of vascular disease, and fasting glucose and insulin, markers of metabolic dysfunction. Additionally, telomere length and interleukin-6, markers of cellular senescence and chronic inflammation, respectively, will represent underlying biological processes that contribute to aging across tissues. If lens transparency is strongly related to these factors, it will provide evidence that transparency reflects cardiovascular disease or diabetes, and/or biological processes underlying aging. Finally, we will examine if lens opacity is associated with physical or cognitive function, markers of performance that indicate organismal aging independent of disease. For this investigation, we will conduct a cross-sectional cohort study in participants of the Healthy Women Study (HWS), a community-based longitudinal cohort study that began in 1983-84 and was just refunded for a 4th examination of the determinants of risk factor changes among women during peri- and postmenopause. To capitalize on the wealth of information obtained in the HWS during the current study cycle, we will add a measure of lens transparency using Scheimpflug photography, which uses linear densitometry to provide a quantitative measure of transparency. Validating lens transparency as a primary marker of aging will allow future researchers to employ it as a benchmark in unraveling the aging process, potentially as a novel intermediate marker for human intervention studies.

描述（由申请人提供）：确定我们是否希望优化个人的福祉，尤其是代表人口越来越多的老年人的福祉，至关重要。传统上，研究衰老等同于无法改变的下降和疾病的发展。尽管不确定衰老的主要影响是否可以与疾病的次要作用完全区分开，但最近的研究表明，衰老和疾病不是同义词，随后可以优化衰老。在具有基因操纵和热量限制的动物模型中，最清楚地证明了这一点。在这些系统中，死亡率一直是衰老的主要标记，但是对于人类研究，需要在体内衰老。在人群研究中，很少有衰老的主要标记得到验证。使用镜头透明度评估的晶状体的衰老被认为是衰老的反映，因为它可以在成年早期至中期被检测到，并且可以与已知的晶状体疾病（包括特定类型的白内障类型）区分开。这项流行病学研究的目的是确定晶状体透明度与疾病的度量和老年妇女队列的衰老量的关联。这些将包括动脉粥样硬化，血管疾病的标志物以及空腹葡萄糖和胰岛素，代谢功能障碍的标志物。另外，细胞衰老和慢性炎症的标记端粒长度和白介素6将代表有助于跨组织衰老的基本生物学过程。如果镜头透明度与这些因素密切相关，它将提供透明度反映心血管疾病或糖尿病和/或衰老衰老的生物学过程的证据。最后，我们将检查镜头不透明度是否与身体或认知功能有关，表明与疾病无关的有机衰老的表现标记。在这项研究中，我们将对健康妇女研究参与者（HWS）进行横断面队列研究，这是一项基于社区的纵向人群研究，该研究始于1983 - 84年，仅退还了对风险决定因素的第四次研究。在绝经期和绝经期间女性的因素变化。为了利用当前研究周期中HWS中获得的大量信息，我们将使用Scheimpflug Photography添加镜头透明度的度量，该摄影使用线性角度测定法来提供透明度的定量度量。验证镜头透明度是衰老的主要标记，将使未来的研究人员能够将其用作揭示衰老过程的基准，这可能是人类干预研究的新型中间标记。