Intestinal Stem Cell Consortium Coordinating Center

肠道干细胞联盟协调中心

基本信息

批准号：
8328973
负责人：
Joyce Carol Niland
金额：
$ 54.27万
依托单位：
BECKMAN RESEARCH INSTITUTE/CITY OF HOPE
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-30 至 2014-08-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8328973
关键词：
Affect Award Bioinformatics Biological Preservation Biology Cells Cessation of life Cities Collection Confidentiality Data Data Coordinating Center Diarrhea Digestive System Disorders Disease Funding Grant Health Human Individual Information Management Information Sciences Information Systems Information Technology Intestinal Diseases Intestines Investments Islet Cell Islets of Langerhans Methods National Institute of Diabetes and Digestive and Kidney Diseases Policies Population Procedures Process Production Quality Control Reporting Research Research Infrastructure Research Personnel Research Project Grants Resources Security Small Intestines Stem Cell Research Stem cells System Techniques Teleconferences Translational Research United States Work biomedical informatics data exchange design experience meetings member programs quality assurance research study therapy development

项目摘要

DESCRIPTION (provided by applicant): We will establish the Intestinal Stem Cell Consortium Coordinating Center (ISCC-CC) at City of Hope. The ISC-CC will be under the direction of Dr. Joyce C. Niland, Chair of Information Sciences. The overall objective of the ISCC-CC is to support the Intestinal Stem Cell Consortium (ISCC) in establishing efficient and effective procedures for the preservation, isolation, and characterization of intestinal stem cells, while developing and validating specific markers for this population of cells. The ISCC-CC will do this by working with investigators from 5-7 different research projects chosen by NIDDK. The ISCC-CC will optimize study administration, coordination, quality control and information management across the ISCC projects. The specific aims are: 1. To provide administrative support and oversight to the ISCC for all Steering and Sub-Committee meetings and teleconference calls; 2. To serve the administrative functions common to all ISCC-CC research projects, coordinating ISCC activities that are best served by centralized ISCC-CC systems and processes; 3. To create and maintain the ISCC information systems and information management processes, using state-of-the-art information technology and robust security/confidentiality; 4. To promote translational research through distribution of ISCC resources, e.g. ISCs, and data exchange of research progress, methods, data, and information between members of the ISCC; and 5. To support the design, analysis and quality assurance of ISCC experiments and data, to optimize the production and sharing of ISCs and develop and validate stem cell markers. PUBLIC HEALTH RELEVANCE: Diseases affecting the small intestine represent a diverse collection of conditions that can cause anything from diarrhea to death in affected individuals. In 2004 digestive diseases were responsible for approximately 236,000 deaths in the United States and nearly $142 billion dollars in direct and indirect expenses. Of those reported deaths, 9836 were attributable, in part of whole, to conditions of the small intestine. Understanding the biology of the small intestine will aid in the development of therapies to treat intestinal diseases.

描述（由申请人提供）：我们将在希望之城建立肠道干细胞联盟协调中心（ISCC-CC）。 ISC-CC 将在信息科学系主任 Joyce C. Niland 博士的指导下进行。 ISCC-CC 的总体目标是支持肠道干细胞联盟 (ISCC) 建立高效且有效的程序来保存、分离和表征肠道干细胞，同时开发和验证该细胞群的特定标记。 ISCC-CC 将通过与 NIDDK 选择的 5-7 个不同研究项目的研究人员合作来实现这一目标。 ISCC-CC 将优化 ISCC 项目的研究管理、协调、质量控制和信息管理。具体目标是： 1. 为 ISCC 的所有指导委员会和小组委员会会议以及电话会议提供行政支持和监督； 2. 履行所有 ISCC-CC 研究项目的共同行政职能，协调由集中式 ISCC-CC 系统和流程提供最佳服务的 ISCC 活动； 3. 使用最先进的信息技术和强大的安全性/保密性，创建和维护 ISCC 信息系统和信息管理流程； 4. 通过 ISCC 资源的分配来促进转化研究，例如ISC，以及 ISCC 成员之间研究进展、方法、数据和信息的数据交换；和 5. 支持ISCC实验和数据的设计、分析和质量保证，优化ISC的生产和共享以及开发和验证干细胞标记物。公共卫生相关性：影响小肠的疾病代表了多种病症，可能导致受影响个体从腹泻到死亡。 2004 年，消化系统疾病导致美国约 236,000 人死亡，造成直接和间接费用近 1,420 亿美元。在报告的死亡人数中，有 9836 人部分或全部归因于小肠疾病。了解小肠的生物学将有助于开发治疗肠道疾病的疗法。