Sixteen channel carbon-13 phased array spectroscopy at 7 Tesla

7 特斯拉十六通道碳 13 相控阵光谱

基本信息

批准号：
8686839
负责人：
Mary Preston McDougall
金额：
$ 13.94万
依托单位：
TEXAS ENGINEERING EXPERIMENT STATION
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-06-20 至 2016-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8686839
关键词：
Adipose tissue Aggressive behavior Bilateral Biological Biopsy Boxing Breast Breast Cancer Treatment Cancer Patient Carbon Cardiovascular Diseases Cell Nucleus Choline Clinical Research Collaborations Detection Diabetes Mellitus Diagnosis Diet Disease Elements Engineering Environment Fatty acid glycerol esters Frequencies Funding Gene Proteins Genetic Image Investigation Life Lipid Chemistry Lipids Magnetic Resonance Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Malignant Neoplasms Mammary Gland Parenchyma Mammary Neoplasms Medical center Medicine Metabolic Metabolic Pathway Metabolism Methods NMR Spectroscopy Noise Nuclear Obesity Pathogenesis Patients Persons Phase Play Predisposing Factor Prevention Process RF coil Reproducibility Research Resolution Role Signal Transduction Site Solutions Spectrum Analysis Surface System Techniques Technology Texas Tissues Universities Vision Woman Work analytical tool base cancer risk design and construction high risk improved in vivo insight interest malignant breast neoplasm metabolic abnormality assessment metabolomics monounsaturated fat prevent public health relevance research study response saturated fat subcutaneous tool tumor

项目摘要

DESCRIPTION (provided by applicant): Nuclear magnetic resonance spectroscopy (NMR or MRS) plays a unique role in the current national effort towards personalized medicine, enabling the investigation of metabolism in intact, functioning tissues inherently integrated with the power of structural and functional MR imaging. While it is recognized that MRS is a unique/advantageous detection technique for metabolic studies, the universally acknowledged crucial drawback is a lack of sensitivity. Adequate signal and the ability to resolve similar molecules are two factors that are essential for practical, routine use of MRS relevant to patients. Both improve dramatically at high fields, making the recent availability of whole body commercial 7T systems a powerful tool added to the armament of biochemists striving to make MRS a practical (i.e. suitably sensitive) in vivo detection tool. A second technique for increasing the sensitivity of the NMR experiment is through the use of phased array RF coils. Ideally then, phased arrays would be used in combination with the benefits of high field MRS. This endeavor is currently hampered by the fact that commercial 7T scanners are limited in their number of multi-nuclear receiver channels, instead enabling the potentially more immediate interest in multi-channel 1H imaging. This proposal aims to overcome this limitation by developing an 'add-on' frequency converter to provide any system with broadband multi-channel capability equal to the number of available 1H channels and by developing surface and volume array coils for 1H and 13C spectroscopy at 7T. This project will leverage and promote distinctive capabilities in an existing collaboration between the Magnetic Resonance Systems Lab at Texas A&M University and the Advanced Imaging Research Center at UT Southwestern Medical Center. The specific metabolic processes to be investigated are part of ongoing studies at UTSW to understand breast cancer and the factors predisposing breast cancer. This work will develop technology to more sensitively detect choline in breast tumors as an indicator of malignancy and a high risk of aggressive behavior of tumors. Another issue of great interest to the public is the role of diet in the pathogenesis of breast cancer, with the general hypothesis that a diet high in saturated and monounsaturated fats is an environmental determinant of breast cancer. It has proven difficult to study the relation of breast fat composition to the risk of cancer with invasive biopsies, and this work will support the role of 13C NMR spectroscopy as a largely unexplored alternative. Three specific aims are outlined to accomplish this work: 1) Build an add-on multi-channel frequency shifting interface box to enable the existing 16-channel 1H receiver on the Philips Achieva 7T scanner at UT Southwestern Medical Center to provide broadband multi-channel receive capability 2) Design and construct 16-channel RF coil arrays for surface and volume 1H and 13C NMR studies at 7T and 3) Demonstrate quantification of the lipid profile and soluble metabolites using multi- channel 13C and 1H MR spectroscopy at 7 Tesla.

描述（由申请人提供）：核磁共振光谱（NMR或MRS）在当前的国家为个性化医学的努力中起着独特的作用，从而可以调查完整的代谢，在完整的组织中与功率固有整合的组织起作用结构和功能性MR成像。尽管人们认识到MRS是一种用于代谢研究的独特/有利检测技术，但普遍承认的关键缺点是缺乏敏感性。足够的信号和解决相似分子的能力是与患者相关的实用，常规使用MRS的两个因素。两者在高场景上都显着改善，使整个身体商业7T系统的最新可用性成为一种强大的工具，它添加了生物化学家的军备，努力使MRS成为实用（即适当敏感）的体内检测工具。增加的第二种技术 NMR实验的敏感性是通过使用相位阵列RF线圈的使用。理想情况下，分阶段阵列将与高场MRS的好处结合使用。目前，商业7T扫描仪的多核接收器渠道数量有限，而是使对多通道1H成像的可能更直接的兴趣。该提案旨在通过开发“附加”频率转换器来克服这一限制，以便提供任何宽带多通道功能等于可用1H通道的数量，并在7T时为1H和13C光谱开发表面和音量阵列线圈。该项目将在德克萨斯A＆M大学的磁共振系统实验室与UT西南医学中心的高级成像研究中心之间的现有合作中利用并促进独特的能力。要研究的特定代谢过程是UTSW正在进行的研究的一部分，以了解乳腺癌及其易感乳腺癌的因素。这项工作将开发技术，以更敏感地检测乳腺肿瘤中的胆碱，以表明肿瘤的侵袭性行为的高风险。公众引起了极大兴趣的另一个问题是饮食在乳腺癌的发病机理，总体假设是饱和和单不饱和脂肪的饮食是乳腺癌的环境决定因素。事实证明，它很难研究乳腺脂肪组成与侵入性活检的癌症风险的关系，这工作将支持13C NMR光谱的作用，这在很大程度上未开发替代方案。概述了三个具体目的以完成这项工作：1）在Philips Achieva 7T扫描仪上建立一个附加的多通道频率转换接口框，以使现有的16通道1H接收器在UT西南医疗中心的Philips Achieva 7T扫描仪上，以提供宽带多渠道的能力2）宽带的功能2）设计和构造16-Channel RF COIL RF RF RF RF RF RF和13c NMRR R.和13C NMRRRER和13C NMRRRER和13C。使用多通道13C和1H MR光谱法处的脂质谱和可溶性代谢产物的形式。