Longitudinal measurement of the changing sleep need in adolescence

青春期睡眠需求变化的纵向测量

• 批准号: 8577026
• 负责人: IRWIN FEINBERG
• 金额: $ 51.17万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-09-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8577026
• 关键词: 14 year old; 16 year old; 17 year old; Address; Adolescence; Adolescent; Affect; Age; Awareness; Beds; Biological; Brain; Centers for Disease Control and Prevention (U.S.); Child; Circadian Rhythms; Cognitive; Complex; Data; Development; Dose; Drowsiness; Electroencephalogram; Electroencephalography; Evaluation; Excessive Daytime Sleepiness; Foundations; Guidelines; Habits; Health behavior; Hour; Hygiene; Individual Differences; Knowledge; Laboratories; Longitudinal Studies; Measurement; Measures; Mental Health; Moods; Participant; Performance; Phase; Physiological; Public Health; Recommendation; Schedule; Schools; Sex Characteristics; Sleep; Teenagers; Testing; Time; Variant; actigraphy; age related; alertness; base; design; falls; longitudinal design; non rapid eye movement; novel; physical conditioning; public health relevance; research study; response; sleep regulation; vigilance

DESCRIPTION (provided by applicant): The negative effects of insufficient sleep in children and adolescents are well documented. Sleep loss and daytime sleepiness impact school performance, health, and behavior. Despite the increasing awareness of the public health impact, major gaps remain in our understanding of adolescent sleep and daytime sleepiness. Currently the Centers for Disease Control and National Sleep Foundation recommend 8.5-9.5 hours of sleep for 10-17 year olds. These guidelines are based on data showing that sleep propensity is stable or even increases across adolescence. However, sleep propensity studies do not address the effects of sleep restriction on daytime functioning. Most studies that have attempted to establish the effects of sleep duration on daytime performance in adolescents have correlated poor performance to poor sleep habits rather than experimentally manipulating prior sleep duration. Moreover, no study has evaluated how the effects of sleep restriction change with age across adolescence. The longitudinal study proposed here will use a within-subject dose-response design to examine the maturational trajectory of sleep need as determined by the relation of experimentally varied sleep duration to daytime functioning and sleepiness. Eighty participants will enter the study between 10 and 14 years of age and be studied for 4 years. Thus, the longitudinal study will cover ages 10 to 18 years. Daytime performance and daytime sleepiness will be measured on separate occasions following four nights with time in bed restricted to 7, 8.5, or 10 hours. Annually all participants will complete the 3 different slee duration conditions within a 3 month period. Daytime performance as well as daytime sleepiness will be measured in laboratory testing sessions. Performance on a simple vigilance task and a more complex cognitive task will be evaluated. Daytime sleepiness will be measured objectively using the same multiple sleep latency test that forms the basis of the Centers for Disease Control adolescent sleep guidelines. Daytime sleepiness will also be measured objectively with theta and alpha electroencephalogram activity, and subjects will subjectively rate their sleepiness and mood. Our previous longitudinal study established that slow wave EEG activity during non-rapid eye movement sleep declines steeply between ages 12 and 16 years of age. The proposed study will determine if the age trajectories of the relations between sleep duration and performance or sleepiness are associated with the adolescent brain maturation reflected in the slow wave EEG decline. Age related circadian changes, determined by actigraphy during a week when subjects keep their habitual sleep scheduled, will be controlled for statistically in the evaluation of maturational changes in the performance vs. sleep duration dose-response curve. The results of this proposed project will provide the first longitudinal dose-response data measuring changes in sleep need across adolescence allowing more informed recommendations for adolescent sleep hygiene.

描述（由申请人提供）：儿童和青少年睡眠不足的负面影响已有充分记录。睡眠不足和白天嗜睡会影响学校表现、健康和行为。尽管人们越来越意识到公共卫生影响，但我们对青少年睡眠和白天嗜睡的理解仍然存在重大差距。目前，疾病控制中心和国家睡眠基金会建议 10-17 岁的人睡眠时间为 8.5-9.5 小时。这些指南基于的数据显示，整个青春期的睡眠倾向是稳定的，甚至是增加的。然而，睡眠倾向研究并未解决睡眠限制对白天功能的影响。大多数试图确定睡眠持续时间对青少年白天表现的影响的研究都将不良表现与不良睡眠习惯联系起来，而不是通过实验来操纵之前的睡眠持续时间。此外，还没有研究评估睡眠限制的影响如何随着青春期年龄的变化而变化。这里提出的纵向研究将使用受试者内剂量反应设计来检查睡眠需求的成熟轨迹，该轨迹是由实验变化的睡眠持续时间与白天功能和困倦的关系确定的。 80 名年龄在 10 岁至 14 岁之间的参与者将进入研究，研究为期 4 年。因此，纵向研究将涵盖 10 至 18 岁的年龄。白天表现和白天困倦将在四个晚上之后的不同场合进行测量，床上时间限制为 7、8.5 或 10 小时。每年，所有参与者都将在 3 个月内完成 3 种不同的睡眠持续时间条件。白天的表现以及白天的困倦将在实验室测试中进行测量。将评估简单的警戒任务和更复杂的认知任务的表现。将使用构成疾病控制中心青少年睡眠指南基础的相同多次睡眠潜伏期测试来客观测量白天嗜睡程度。白天的睡意也将通过 θ 和 α 脑电图活动进行客观测量，受试者将主观地评估他们的睡意和情绪。我们之前的纵向研究表明，非快速眼动睡眠期间的慢波脑电图活动在 12 岁至 16 岁之间急剧下降。拟议的研究将确定睡眠持续时间和表现或困倦之间关系的年龄轨迹是否与慢波脑电图下降所反映的青少年大脑成熟有关。与年龄相关的昼夜节律变化，通过受试者保持习惯性睡眠安排的一周内的体动记录仪确定，将在评估表现与睡眠持续时间剂量反应曲线的成熟变化时进行统计控制。该拟议项目的结果将提供第一个纵向剂量反应数据，测量整个青春期睡眠需求的变化，从而为青少年睡眠卫生提供更明智的建议。