Effects of amygdala neurofeedback on depressive symptoms and processing biases

杏仁核神经反馈对抑郁症状和处理偏差的影响

• 批准号: 8698608
• 负责人: Kym Young
• 金额: $ 9万
• 依托单位: LAUREATE INSTITUTE FOR BRAIN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8698608
• 关键词: Adverse effects; Amygdaloid structure; Anterior; Antidepressive Agents; Attention; Attenuated; Award; Awareness; Beck depression inventory; Behavior; Biological; Biological Markers; Biomedical Research; Brain region; Clinic; Clinical; Clinical Trials Unit; Clinics and Hospitals; Cognitive Therapy; Conscious; Deep Brain Stimulation; Discipline; Disease; Disease remission; Drops; Electroconvulsive Therapy; Electroencephalography; Emotional; Emotions; Exhibits; Exposure to; Face; Faculty; Functional Imaging; Functional Magnetic Resonance Imaging; Functional disorder; Goals; Individual; Institutes; Intervention; Learning; Left; Magnetic Resonance Imaging; Major Depressive Disorder; Masks; Measures; Medial; Memory; Mental Depression; Mental disorders; Mentors; Methodology; Methods; Mission; Mood Disorders; Moods; Neurosciences; Participant; Pathway interactions; Patients; Pattern; Phase; Plastics; Play; Population; Positioning Attribute; Postdoctoral Fellow; Prefrontal Cortex; Procedures; Process; Publications; Recovery; Research; Research Institute; Research Personnel; Resources; Role; Scientist; Selective Serotonin Reuptake Inhibitor; Severities; Stimulus; Symptoms; Techniques; Technology; Testing; Time; Training; Universities; Work; affective neuroscience; base; blood oxygen level dependent; brain research; cingulate cortex; cognitive neuroscience; depressive symptoms; effective therapy; emotion regulation; experience; hemodynamics; improved; insight; intraparietal sulcus; medical schools; neural circuit; neurobehavioral; neurobiological mechanism; neurofeedback; neuroimaging; neuropsychiatry; novel; programs; psychologic; public health relevance; relating to nervous system; response; skills; translational neuroscience; vagus nerve stimulation; years lived with disability

DESCRIPTION (provided by applicant): In this revised application for a Pathway to Independence Award (K99/R00), Dr. Kymberly Young requests support to acquire the training necessary to establish herself as an independent investigator studying novel neurobehavioral interventions for major depressive disorder (MDD), with a specific focus on emotional processing biases that serve as a biological marker and treatment target both for the onset and remission of MDD symptoms. Accomplishing this long-term goal requires that Dr. Young develop skills that cut across disciplines, including the clinical neuroscience of MDD, translational neuroscience, and functional neuroimaging. Her prior training and publication record clearly indicate that Dr. Young has expertise in cognitive neuroscience and the biological basis of depression. In order to fully attain her goals, however, she needs additional training and experience that comes from working with experts in the field of neurobehavioral treatments of psychiatric disorders and cutting-edge functional neuroimaging techniques. To that end, Dr. Young will receive mentoring in neurobehavioral treatments for MDD from Dr. Greg Siegle, director of the Program in Cognitive and Affective Neuroscience at University of Pittsburgh School of Medicine, who is also on the executive team of the Mood Disorders Treatment and Research Program, which serves as the clinical trials unit for the Western Psychiatric Institute and Clinic. To receive training in cutting-edge functional neuroimaging methods, Dr. Young will work closely with Dr. Jerzy Bodurka, an internationally-renowned MRI physicist with expertise in advanced blood-oxygen level dependent (BOLD) fMRI techniques and methodology, and the Chief Technology Officer and director of the Laureate Institute for Brain Research (LIBR) MRI and EEG facility. The training, and associated research, will take place at LIBR, a state-of-the-art independent biomedical research institute dedicated to conducting neuroimaging research with the mission of developing effective treatments for neuropsychiatric disorders. LIBR is affiliated with the Laureate Psychiatric Clinic and Hospital, which provides exceptional access to clinical populations available for research, particularly patients with MDD. With the training offered by her mentors and collaborators, and institutional resources at LIBR, Dr. Young will be able to achieve the research objectives of this proposal, namely to determine the degree to which real-time fMRI neurofeedback (rtfMRI-nf) enhances voluntary control over amygdala neural activity, co-modulates other brain regions within the emotion regulation circuitry, and alters depressive symptom severity ratings (Specific Aim 1). She also will determine the degree amygdala rtfMRI-nf restores a normative emotional processing bias during exposure to emotionally valenced stimuli (Specific Aim 2). Finally, this training will prepare Dr. Young for th R00 phase of the award in which she will transition to an independent faculty-level research position and investigate whether the time course of symptom improvement and the overall efficacy of cognitive behavioral therapy can be improved by augmenting it with rtfMRI-nf involving amygdala activity (Specific Aim 3).

描述（由申请人提供）：在独立之路奖 (K99/R00) 的修订申请中，Kymberly Young 博士请求支持以获得必要的培训，使自己成为一名研究重度抑郁症新型神经行为干预措施的独立研究者（ MDD），特别关注情绪处理偏差，作为 MDD 症状发作和缓解的生物标记和治疗目标。要实现这一长期目标，Young 博士需要培养跨学科的技能，包括 MDD 的临床神经科学、转化神经科学和功能神经影像学。她之前的培训和出版记录清楚地表明，杨博士拥有认知神经科学和抑郁症生物学基础方面的专业知识。然而，为了完全实现她的目标，她需要额外的培训和 与精神疾病神经行为治疗和尖端功能神经影像技术领域的专家合作的经验。为此，Young 博士将接受匹兹堡大学医学院认知和情感神经科学项目主任、情绪障碍治疗执行团队成员 Greg Siegle 博士的 MDD 神经行为治疗指导。和研究计划，作为西方精神病学研究所和诊所的临床试验单位。为了接受尖端功能神经成像方法的培训，Young 博士将与国际知名 MRI 物理学家 Jerzy Bodurka 博士密切合作，Jerzy Bodurka 博士在先进的血氧水平依赖 (BOLD) fMRI 技术和方法方面拥有专业知识，并且首席技术获奖者大脑研究所 (LIBR) MRI 和 EEG 设施的官员兼主任。培训和相关研究将在 LIBR 进行，LIBR 是一家最先进的独立生物医学研究机构，致力于进行神经影像研究，其使命是开发神经精神疾病的有效治疗方法。 LIBR 隶属于 Laureate 精神病诊所和医院，为研究提供了特殊的临床人群，特别是 MDD 患者。凭借导师和合作者提供的培训以及 LIBR 的机构资源，Young 博士将能够实现本提案的研究目标，即确定实时功能磁共振成像神经反馈 (rtfMRI-nf) 增强自愿性的程度控制杏仁核神经活动，共同调节情绪调节回路内的其他大脑区域，并改变抑郁症状严重程度评级（具体目标 1）。她还将确定杏仁核 rtfMRI-nf 在暴露于情绪效价刺激期间恢复正常情绪处理偏差的程度（具体目标 2）。最后，本次培训将为 Young 博士做好准备，为该奖项的 R00 阶段做好准备，她将过渡到独立的教职级研究职位，并研究是否可以通过以下方式改善症状改善的时间进程和认知行为治疗的整体疗效：使用涉及杏仁核活动的 rtfMRI-nf 对其进行增强（具体目标 3）。