Chronic Kidney Disease in Children (CKiD III)

儿童慢性肾脏病 (CKiD III)

基本信息

批准号：
8581783
负责人：
Bradley Alan Warady
金额：
$ 95.59万
依托单位：
CHILDREN'S MERCY HOSP (KANSAS CITY, MO)
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-09-30 至 2018-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8581783
关键词：
11 year old Acidosis Acute Renal Failure with Renal Papillary Necrosis Address Adverse effects African American Albuminuria Ancillary Study Anemia Attention Behavior Biological Markers Birth History Blood Pressure Canada Cardiac Cardiovascular Diseases Child Childhood Chronic Kidney Failure Cities Classification Clinical Clinical Research Clip Cohort Studies Collaborations Controlled Study Data Data Coordinating Center Development Diagnosis Disease Disease Progression Enrollment Environmental Exposure Etiology Failure Functional disorder Funding Future Gestational Diabetes Goals Gold Growth Growth and Development function Hair Healthcare Systems Heart Diseases Height High Prevalence Hospitals Hypertension Hypoalbuminemia Individual Injury International Intervention K-Series Research Career Programs Kansas Kidney Kidney Diseases Laboratories Low Birth Weight Infant Magnetic Resonance Imaging Measurement Measures Morbidity - disease rate Myocardial Neonatal Nephrology Neurocognitive Newborn Infant North America Outcome Participant Pediatric Hospitals Performance Perinatal Philadelphia Physiologic pulse Plasma Play Potassium Phosphate Prevalence Principal Investigator Procedures Process Prospective Studies Proteinuria Public Health Schools Quality Control Quality of life Race Recording of previous events Recruitment Activity Renal function Renal glomerular disease Reporting Research Design Research Infrastructure Research Personnel Risk Risk Factors Role Sampling Sepsis Site Smoking History Structure Structure of nail of finger Structure of nail of toe Therapeutic Intervention Therapy Clinical Trials U-Series Cooperative Agreements United States National Institutes of Health Universities Urine Visit Weight Gain Youth aged arterial stiffness cardiovascular disorder risk cognitive function cohort executive function follow-up genome wide association study improved maternal cigarette smoking meetings member mortality novel novel strategies prenatal prospective public health relevance young adult

项目摘要

DESCRIPTION (provided by applicant): The Chronic Kidney Disease in Children Study (CKiD) is a multi-center, prospective cohort study of children aged 1 to 16 years with mild to moderately impaired kidney function at study entry. Two clinical coordinating centers (CCCs) (at the Children's Hospital of Philadelphia (CHOP), and Children's Mercy Hospital (CMH) in Kansas City), a central laboratory (at the University of Rochester), and a data coordinating center (at Johns Hopkins Bloomberg School of Public Health) have formed a cooperative agreement to conduct this prospective study of chronic kidney disease in children. Since its inception in 2003, the scientific aims of CKiD have been to determine the risk factors for decline in kidney function and the effects of kidney function decline on risk factors for cardiovascular disease; growth failure and its associated morbidity; and neurocognitive function and behavior. The purpose of this application is to request funds to continue the cohort study from August, 2013 to July, 2018. The aims of the current proposal are to assess and improve the accuracy and precision of the CKiD estimating formulas in youth with early CKD, to define the risk of kidney disease progression in children according to the Kidney Disease Improving Global Outcomes (KDIGO) classification of CKD according to Cause, GFR and level of albuminuria, to define risk factors for accelerated and non-linear decline in GFR among strata of children with glomerular compared to non-glomerular diagnoses and in African Americans, and to assess physical performance, arterial stiffness and myocardial structure and function as GFR declines. The Midwest Clinical Coordinating Center Principal Investigator has clinical expertise in kidney disease in children, clinical research design, recruitment and retention, quality control of study procedures, and organization of collaboration across the multiple participating sites in CKiD. The CKiD study encompasses a geographically and racially diverse cohort. The structure of CKiD and its support of ancillary studies continue to stimulate novel approaches to identify risk factors for kidney disease progression. The infrastructure of CKiD continues to serve as a platform for career development awards for junior investigators and ancillary R01's for more senior colleagues. With longer follow-up and additional recruitment of subjects with mild kidney dysfunction and glomerular disease, we will continue to characterize novel biomarkers of kidney injury that are associated with CKD progression and its sequellae to inform future therapeutic trials.

描述（由申请人提供）：儿童慢性肾脏病研究 (CKiD) 是一项多中心、前瞻性队列研究，对象为 1 至 16 岁的儿童，研究对象为在研究开始时肾功能轻度至中度受损的儿童。两个临床协调中心 (CCC)（位于费城儿童医院 (CHOP) 和堪萨斯城儿童慈善医院 (CMH)）、一个中心实验室（位于罗切斯特大学）和一个数据协调中心（位于约翰·霍普金斯大学）彭博公共卫生学院）已达成一项合作协议，以开展这项儿童慢性肾病的前瞻性研究。自2003年成立以来，CKiD的科学目标一直是确定肾功能下降的危险因素以及肾功能下降对心血管疾病危险因素的影响；生长障碍及其相关发病率；以及神经认知功能和行为。本申请的目的是申请资金以继续进行从 2013 年 8 月到 2018 年 7 月的队列研究。当前提案的目的是评估和提高早期 CKD 青少年中 CKiD 估计公式的准确性和精确度，以根据改善肾脏病全球结局 (KDIGO) 的 CKD 分类，根据病因、GFR 和蛋白尿水平，定义儿童肾脏疾病进展的风险，以确定儿童肾脏疾病进展的风险因素与非肾小球诊断和非裔美国人相比，肾小球儿童各层的 GFR 加速且非线性下降，并评估 GFR 下降时的身体表现、动脉僵硬度以及心肌结构和功能。中西部临床协调中心首席研究员在儿童肾脏疾病、临床研究设计、招募和保留、研究程序的质量控制以及 CKiD 多个参与中心的合作组织方面拥有临床专业知识。 CKiD 研究涵盖了地理和种族多样化的队列。 CKiD 的结构及其对辅助研究的支持继续激发新方法来识别肾脏疾病进展的危险因素。 CKiD 的基础设施继续作为初级研究人员职业发展奖和高级同事辅助 R01 的平台。随着更长时间的随访和额外招募患有轻度肾功能障碍和肾小球疾病的受试者，我们将继续表征与 CKD 进展及其后遗症相关的新型肾损伤生物标志物，为未来的治疗试验提供信息。