Acquisition of a Q-TOF Mass Spectrometer

购买 Q-TOF 质谱仪

基本信息

批准号：
8246986
负责人：
WEI LI
金额：
$ 32.5万
依托单位：
UNIVERSITY OF TENNESSEE HEALTH SCI CTR
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-05-01 至 2013-04-30
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): This application requests funding to acquire a Q-TOF mass spectrometer to replace the mass spectrometer component of an 18-year-old Bruker Esquire-LC/MS system, which is an essential part of the Shared Instrument Facility in the Department of Pharmaceutical Sciences at the University of Tennessee Health Science Center (UTHSC). The Bruker Esquire-LC/MS system has been well maintained and is the work horse supporting extensive small-molecular drug discovery and drug delivery programs at UTHSC in the areas of cancer, obesity, diabetes, radiation protection, radiation mitigation, bacteria inflection, and inflammation diseases. Several small-molecule drug candidates have been licensed for commercial development, including one currently in Phase III clinical trials. However, the age of the current mass spectrometer has resulted in more and more frequent breakdowns in recent years. Bruker officially stopped technical support for this type of instrument system in early 2010. Repair parts are scarce and have become very expensive. The proposed new Q-TOF mass spectrometer will replace the now unreliable mass spectrometer component of the Bruker Esquire-LC/MS system. This powerful new mass spectrometer will benefit more than 10 principal investigators supported by nine R01s, one RC2, one R33, three R21s, and other sources of support. The Q-TOF mass spectrometer will provide years of reliable accessibility, greater sensitivity in both MS and MS/MS modes, and the capability to obtain accurate mass for more efficient structure elucidation. This state-of-the-art instrument wil support drug discovery in preclinical development by using novel small molecules and their translation to innovative therapies for a variety of diseases. UTHSC is strongly committed to supporting biomedical research. The College of Pharmacy will provide $25,000 as a cost share for the purchase of the new instrument, fully support a staff scientist to maintain the Shared Instrument Facility, and assume all future maintenance and repair cost after the warranty period without charging user fees. An advisory committee will ensure effective utilization of the instrument and adequate access by the major users, other NIH-supported investigators, new investigators, and investigators with early-stage projects. PUBLIC HEALTH RELEVANCE: The Q-TOF mass spectrometer requested will replace a technologically limited Esquire-LC/MS mass spectrometer that is nearly two decades old and will provide reliable and sophisticated support for 20 currently funded projects important to human health. These projects focus on small-molecule drug discovery and drug delivery in the areas of cancer, obesity, diabetes, radiation protection, radiation mitigation, bacteria inflection and inflammation diseases.

描述（由申请人提供）：本申请请求资金购买 Q-TOF 质谱仪，以替换已有 18 年历史的 Bruker Esquire-LC/MS 系统的质谱仪组件，该系统是共享仪器设施的重要组成部分田纳西大学健康科学中心 (UTHSC) 药学系。 Bruker Esquire-LC/MS 系统维护良好，是支持 UTHSC 广泛的小分子药物发现和药物输送项目的主力，涉及癌症、肥胖、糖尿病、辐射防护、辐射缓解、细菌感染和炎症疾病。几种小分子候选药物已获得商业开发许可，其中一种目前处于 III 期临床试验中。然而，近年来，当前质谱仪的老化导致故障越来越频繁。布鲁克于 2010 年初正式停止对此类仪器系统的技术支持。维修零件稀缺且变得非常昂贵。拟议的新型 Q-TOF 质谱仪将取代 Bruker Esquire-LC/MS 系统中目前不可靠的质谱仪组件。这款功能强大的新型质谱仪将使 10 多名主要研究人员受益，并得到 9 个 R01、1 个 RC2、1 个 R33、3 个 R21 和其他支持来源的支持。 Q-TOF 质谱仪将提供多年的可靠可访问性、MS 和 MS/MS 模式下更高的灵敏度，以及获得精确质量以更有效地进行结构解析的能力。这种最先进的仪器将通过使用新型小分子及其转化为多种疾病的创新疗法来支持临床前开发中的药物发现。 UTHSC 坚定致力于支持生物医学研究。药学院将提供25,000美元作为购买新仪器的费用分摊，全力支持一名科学家维护共享仪器设施，并承担保修期后的所有未来维护和维修费用，不收取用户费用。咨询委员会将确保主要用户、NIH 支持的其他研究人员、新研究人员和早期项目的研究人员能够有效利用该仪器并充分使用该仪器。公共健康相关性：所要求的 Q-TOF 质谱仪将取代技术有限的 Esquire-LC/MS 质谱仪，该质谱仪已有近 20 年的历史，将为目前资助的 20 个对人类健康重要的项目提供可靠和复杂的支持。这些项目重点关注癌症、肥胖、糖尿病、辐射防护、辐射缓解、细菌感染和炎症疾病领域的小分子药物发现和药物输送。