Finding effective treatments for inhaled chlorine-induced injury related pain

寻找吸入氯引起的损伤相关疼痛的有效治疗方法

基本信息

批准号：
8416168
负责人：
Sadis Matalon
金额：
$ 36.63万
依托单位：
UNIVERSITY OF ALABAMA AT BIRMINGHAM
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-09-28 至 2014-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8416168
关键词：
Accidents Adrenergic Agonists Adrenergic Receptor Adrenergic beta-Agonists Adverse effects Affect Agonist Anesthetics Anti-Inflammatory Agents Anti-inflammatory Antidotes Behavioral Biochemical Biochemical Markers Breathing Bronchial Spasm Bronchoalveolar Lavage Cardiovascular system Caring Cessation of life Chemical Warfare Chest Pain Chlorine Clinical Clinical Treatment Controlled Clinical Trials Coronary Arteriosclerosis Coughing Coupled Data Devices Dyspnea Equipment Evaluation Event Exposure to Functional disorder Gases Hand Hospitals Hypoxia Individual Industrial Accidents Inflammation Injury Irritants Laboratories Lidocaine Literature Local Anesthetics Locomotion Lung Measurement Measures Medical Methodology Modeling Morbidity - disease rate Movement Mus Nebulizer Neurologic Nose Opioid Oral cavity Oxygen saturation measurement Pain Pharmaceutical Preparations Poisoning Pump Regimen Respiration Respiratory Failure Respiratory physiology Sampling Sensory Serum Stridor Structure Structure of parenchyma of lung Symptoms System Terrorism Testing Tissues Toxic effect Translating Transportation Vent World War I base cardiopulmonary system clinical practice effective therapy improved irritation lung injury men mortality novel therapeutic intervention pain behavior planetary Atmosphere respiratory response treatment effect

项目摘要

DESCRIPTION (provided by applicant): Chlorine (Cl2) is a highly irritant and reactive gas produced in large quantities throughout the world. Exposure to Cl2 released into the atmosphere during transportation and industrial accidents, as well as acts of terrorism, has resulted in significant lung injury leading to death from respiratory failure or significant morbidty. Our recent data show that there may be benefit to treating subjects exposed to Cl2 with inhaled local anesthetics. The present studies will examine the effects of this treatment as monotherapy or in combination with a beta adrenergic agonist on measures of pain and inflammation in murine models. PUBLIC HEALTH RELEVANCE: We will assess whether inhaled local anesthetics alone and as an adjunct to beta adrenoceptor agonist, will be effective in reducing pain behaviors and in reducing morbidity and mortality following Cl2 exposure in mice.

描述（由申请人提供）：氯 (Cl2) 是一种高刺激性和反应性气体，在世界各地大量生产。接触运输和工业事故以及恐怖主义行为期间释放到大气中的 Cl2 会导致严重的肺损伤，导致呼吸衰竭或严重发病死亡。我们最近的数据表明，用吸入局部麻醉剂治疗暴露于 Cl2 的受试者可能会有好处。目前的研究将检查这种治疗作为单一疗法或与β肾上腺素能激动剂联合治疗对小鼠模型疼痛和炎症的影响。公共卫生相关性：我们将评估单独吸入局部麻醉剂以及作为 β 肾上腺素受体激动剂的辅助剂是否能有效减少小鼠 Cl2 暴露后的疼痛行为并降低发病率和死亡率。