Harvard Trauma Inflammation Training Program

哈佛创伤炎症培训计划

• 批准号: 8689119
• 负责人: WOLFGANG G JUNGER
• 金额: $ 12.52万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8689119
• 关键词: Inflammation; Training Programs; Trauma

DESCRIPTION (provided by applicant): This application seeks funding for a T32 Training Program in Trauma, Burn, and Peri-operative Injury for 3 MD and 3 PhD trainees who will conduct trauma research in the laboratories of translationally oriented physician scientists and basic researchers at the Beth Israel Deaconess Medical Center (BIDMC) and other affiliated teaching hospitals of Harvard Medical School (HMS). The Harvard Longwood Medical Area holds an impressive array of clinical and research facilities that will be an ideal setting for the proposed T32 program, which will be the first of its kind in this area. The program will be directed by a multidisciplinary team of experienced leaders in the field of trauma, shock, and inflammation research. The research focus of this proposed program is centered on the early events leading to the inflammatory process and organ failure triggered by trauma with the aim of developing novel treatments to prevent inflammation to organ dysfunction. We propose a training program that will teach state-of-the-art knowledge in immunology, biochemistry, molecular biology, and the innate immune response to trauma. A long-term goal is to develop future leaders in the field of trauma research who have the necessary interdisciplinary teamwork skills that are required for to make tangible progress in the field. We propose to teach these skills by pairing MD and PhD trainees. These pairs will work in close interdisciplinary teams. MD trainees will help their PhD partners understand actual clinical problems in trauma care; PhD trainees will teach their MD partners how to address these problems with leading-edge science approaches. Both partners will lean how to communicate effectively with one another and how to solve real clinical problems in mutually beneficial interdisciplinary research teams. The need for this innovative training approach is driven by the following rationale: ¿ despite intense research efforts over several decades, inflammatory complications, immune dysfunction, and organ failure have remained major causes of post-traumatic morbidity and mortality. ¿ Remarkable progress in clinical trauma care and vast improvements in our understanding of the immunological, cellular, and molecular processes that drive post-traumatic inflammation have not translated into corresponding improvements in clinical outcome. ¿ A core reason for this deficit is inadequate information flow among clinical and basic researchers. Thus, a new paradigm of science training is needed to raise leaders in trauma research who can bridge this gap by developing strong interdisciplinary teamwork skills that help them advance the field and improve clinical outcome after trauma. The program directors themselves have established such interdisciplinary partnerships and will therefore serve as role models. They have gathered an impressive group of highly respected and motivated basic researcher and clinical faculty who will mentor trainees in their laboratories. We propose a program that will host 3 MD and 3 PhD trainees for a minimum of 2 years each in trauma related research laboratories. MDs are expected to have completed 2-3 years of clinical training in general surgery and to pursue an academic career in critical care, trauma surgery, or related specialties. PhD candidates will be selected based on documented interest or experience in trauma or inflammation research, immunology, or in related fields of study. In order to promote interdisciplinary team working skills, trainees will form 3 teams consisting of a PhD and MD trainee each. Each team partner will work on individual projects within related topics in trauma research. They will be encouraged to form close ties through joint attendance of conferences, seminars, and lectures. MD trainees will guide their PhD partner on clinical rounds to provide an in-depth understanding of actual clinical problems in the care for critically ill trauma patients. PhD trainees in turn will provide their MD partners with advice and assistance in the design of experiments and research strategies as well as exposure to new technologies. This training program will help trainees recognize the value of interdisciplinary team work and the benefit of vigorous information flow between closely collaborating clinical and basic scientists. This training approach and the excellent research infrastructure in the Harvard Longwood Area will help us achieve our overall goals, namely to develop a new breed of skilled researcher who can advance the field of trauma research and improve clinical trauma care.

描述（由申请人提供）：本申请为创伤、烧伤和围手术期损伤的 T32 培训计划寻求资金，该计划面向 3 名医学博士和 3 名博士学员，他们将在以下机构的转化型医师科学家和基础研究人员的实验室中进行创伤研究：哈佛朗伍德医学区拥有一系列令人印象深刻的临床和研究设施，是理想的选择。设置为 拟议的 T32 项目将是该领域的首个此类项目，该项目将由创伤、休克和炎症研究领域经验丰富的领导者组成的多学科团队指导。创伤引发的炎症过程和器官衰竭的早期事件，旨在开发新的治疗方法来预防炎症导致器官功能障碍。我们提出了一个培训计划，教授免疫学、生物化学、分子方面的最先进知识。生物学和先天免疫反应长期目标是培养创伤研究领域的未来领导者，他们拥有在该领域取得切实进展所需的跨学科团队合作技能。我们建议通过配对医学博士和博士生来教授这些技能。这些搭档将在紧密的跨学科团队中工作，医学博士实习生将帮助他们的博士合作伙伴了解创伤护理中的实际临床问题；博士实习生将教他们的医学博士合作伙伴如何使用前沿的科学方法解决这些问题。有效地相互配合以及如何解决实际的临床问题互惠互利的跨学科研究团队对这种创新培训方法的需求是由以下理由驱动的： ¿尽管几十年来进行了大量的研究工作，炎症并发症、免疫功能障碍和器官衰竭仍然是创伤后发病和死亡的主要原因。临床创伤护理方面的显着进展以及我们对驱动创伤后炎症的免疫学、细胞和分子过程的理解的巨大进步并没有转化为临床结果的相应改善。造成这种缺陷的一个核心原因是临床和基础研究人员之间的信息流动不足，因此，需要一种新的科学培训范式来培养创伤研究领域的领导者，他们可以通过培养强大的跨学科团队合作技能来弥补这一差距，从而帮助他们推进该领域的发展。项目负责人本身已经建立了这种跨学科合作伙伴关系，因此他们聚集了一批备受尊敬和积极主动的基础研究人员和临床教师，他们将在他们的实验室中指导学员。该项目将容纳 3 名医学博士和 3 名博士创伤相关研究实验室的受训医学博士预计将完成 2-3 年的普通外科临床培训，并在重症监护、创伤外科或相关专业从事学术职业。根据对创伤或炎症研究、免疫学或相关研究领域的记录兴趣或经验进行选择，为了提高跨学科团队工作技能，学员将组成 3 个团队，每个团队由一名博士和医学博士学员组成。从事相关主题内的个人项目我们鼓励他们通过共同参加会议、研讨会和讲座来建立密切的联系，医学博士实习生将指导他们的博士合作伙伴进行临床查房，以深入了解重症患者护理中的实际临床问题。创伤患者将依次提供。 他们的医学博士合作伙伴在实验和研究策略的设计以及接触新技术方面提供建议和帮助。该培训计划将帮助学员认识到跨学科团队合作的价值以及密切合作的临床和基础科学家之间活跃的信息流的好处。这种培训方法和哈佛朗伍德地区优秀的研究基础设施将帮助我们实现我们的总体目标，即培养新一代熟练的研究人员，他们可以推进创伤研究领域并改善临床创伤护理。