Harvard Trauma Inflammation Training Program

哈佛创伤炎症培训计划

• 批准号: 8689119
• 负责人: WOLFGANG G JUNGER
• 金额: $ 12.52万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-07-01 至 2018-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8689119
• 关键词: Inflammation; Training Programs; Trauma

DESCRIPTION (provided by applicant): This application seeks funding for a T32 Training Program in Trauma, Burn, and Peri-operative Injury for 3 MD and 3 PhD trainees who will conduct trauma research in the laboratories of translationally oriented physician scientists and basic researchers at the Beth Israel Deaconess Medical Center (BIDMC) and other affiliated teaching hospitals of Harvard Medical School (HMS). The Harvard Longwood Medical Area holds an impressive array of clinical and research facilities that will be an ideal setting for the proposed T32 program, which will be the first of its kind in this area. The program will be directed by a multidisciplinary team of experienced leaders in the field of trauma, shock, and inflammation research. The research focus of this proposed program is centered on the early events leading to the inflammatory process and organ failure triggered by trauma with the aim of developing novel treatments to prevent inflammation to organ dysfunction. We propose a training program that will teach state-of-the-art knowledge in immunology, biochemistry, molecular biology, and the innate immune response to trauma. A long-term goal is to develop future leaders in the field of trauma research who have the necessary interdisciplinary teamwork skills that are required for to make tangible progress in the field. We propose to teach these skills by pairing MD and PhD trainees. These pairs will work in close interdisciplinary teams. MD trainees will help their PhD partners understand actual clinical problems in trauma care; PhD trainees will teach their MD partners how to address these problems with leading-edge science approaches. Both partners will lean how to communicate effectively with one another and how to solve real clinical problems in mutually beneficial interdisciplinary research teams. The need for this innovative training approach is driven by the following rationale: ¿ despite intense research efforts over several decades, inflammatory complications, immune dysfunction, and organ failure have remained major causes of post-traumatic morbidity and mortality. ¿ Remarkable progress in clinical trauma care and vast improvements in our understanding of the immunological, cellular, and molecular processes that drive post-traumatic inflammation have not translated into corresponding improvements in clinical outcome. ¿ A core reason for this deficit is inadequate information flow among clinical and basic researchers. Thus, a new paradigm of science training is needed to raise leaders in trauma research who can bridge this gap by developing strong interdisciplinary teamwork skills that help them advance the field and improve clinical outcome after trauma. The program directors themselves have established such interdisciplinary partnerships and will therefore serve as role models. They have gathered an impressive group of highly respected and motivated basic researcher and clinical faculty who will mentor trainees in their laboratories. We propose a program that will host 3 MD and 3 PhD trainees for a minimum of 2 years each in trauma related research laboratories. MDs are expected to have completed 2-3 years of clinical training in general surgery and to pursue an academic career in critical care, trauma surgery, or related specialties. PhD candidates will be selected based on documented interest or experience in trauma or inflammation research, immunology, or in related fields of study. In order to promote interdisciplinary team working skills, trainees will form 3 teams consisting of a PhD and MD trainee each. Each team partner will work on individual projects within related topics in trauma research. They will be encouraged to form close ties through joint attendance of conferences, seminars, and lectures. MD trainees will guide their PhD partner on clinical rounds to provide an in-depth understanding of actual clinical problems in the care for critically ill trauma patients. PhD trainees in turn will provide their MD partners with advice and assistance in the design of experiments and research strategies as well as exposure to new technologies. This training program will help trainees recognize the value of interdisciplinary team work and the benefit of vigorous information flow between closely collaborating clinical and basic scientists. This training approach and the excellent research infrastructure in the Harvard Longwood Area will help us achieve our overall goals, namely to develop a new breed of skilled researcher who can advance the field of trauma research and improve clinical trauma care.

DESCRIPTION (provided by application): This application seeks funding for a T32 Training Program in Trauma, Burn, and Peri-operative Injury for 3 MD and 3 PhD trainees who will conduct trauma research in the laboratories of translateally oriented physical scientists and basic researchers at the Beth Israel Deaconess Medical Center (BIDMC) and other affiliate teaching hospitals of Harvard Medical School (HMS).哈佛大学朗伍德医疗区拥有一系列令人印象深刻的临床和研究设施，这将是理想的环境 拟议的T32计划将是该领域的第一个此类计划。该计划将由创伤，震惊和感染研究领域经验丰富的领导者的多学科团队指导。该提出的计划的研究重点集中在创伤引起的炎症过程和器官衰竭的早期事件上，目的是开发新的治疗方法以防止感染到器官功能障碍。我们提出了一项培训计划，该计划将教授免疫学，生物化学，分子生物学和对创伤的先天免疫应答方面的最先进知识。一个长期的目标是培养创伤研究领域的未来领导者，他们具有在该领域取得切实进步所需的必要跨学科团队合作技能。我们建议通过配对MD和PhD学员来教授这些技能。这些对将在密切的跨学科团队中工作。 MD学员将帮助他们的博士合作伙伴了解创伤护理中的实际临床问题；博士学员将教他们的MD合作伙伴如何通过领先的科学方法来解决这些问题。双方的合作伙伴将倾向于如何在互惠互利的跨学科研究团队中解决真正的临床问题如何有效地沟通。这种创新的培训方法的需求是由以下基本原理驱动的：尽管几十年来进行了激烈的研究工作，炎症并发症，免疫功能障碍和器官衰竭仍然是创伤后发病率和死亡率的主要原因。在临床创伤护理中的显着进步以及我们对驱动创伤后炎症的免疫，细胞和分子过程的理解方面的显着改善尚未转化为相应的临床结果改善。这种辩护的核心原因是临床和基础研究人员之间的信息流不足。这是需要新的科学训练范式来提高创伤研究领域的领导者，他们可以通过发展强大的跨学科团队合作技能来弥合这一差距，从而帮助他们提高领域并改善创伤后的临床结果。计划主管本身已经建立了这种跨学科伙伴关系，因此将作为榜样。他们聚集了一群令人印象深刻的基础研究员和临床教师，他们将在实验室中指导受训者。我们提出了一项计划，该计划将在相关的研究实验室中至少拥有3个MD和3位博士学生的学员2年。预计MDS将在一般手术中完成2 - 3年的临床培训，并从事重症监护，创伤手术或相关专业的学术职业。候选人将根据创伤或感染研究，免疫学或相关研究领域的兴趣或经验进行选择。为了促进跨学科团队的工作技能，学员将组成由博士和医学博士学位者组成的3个团队。每个团队合作伙伴将在创伤研究中的相关主题中进行单个项目。鼓励他们通过共同出席会议，半手和讲座建立紧密的联系。 MD学员将在临床回合上指导其博士合作伙伴，以深入了解重症患者的实际临床问题。博士学位学员又将提供 他们的MD合作伙伴在设计实验和研究策略的设计方面以及对新技术的曝光方面的建议和帮助。该培训计划将帮助受训者认识到跨学科团队工作的价值，以及紧密合作的临床和基础科学家之间的剧烈信息流的好处。这种培训方法和哈佛朗伍德地区的优秀研究基础设施将有助于我们实现总体目标，即开发一种新的熟练研究人员，他们可以推进创伤研究领域并改善临床创伤护理。