Childhood Infection Research Program

儿童感染研究计划

• 批准号: 8304900
• 负责人: Mark R Denison
• 金额: $ 27.68万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-08-01 至 2016-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8304900
• 关键词: Childhood; Infection; Research; programs

DESCRIPTION (provided by applicant): This application requests support for the Vanderbilt "Childhood Infections Research Program" (ChIRP) a new postdoctoral scientist training program in basic and clinical-translational science for MD and MD/PhD clinical fellows in Pediatric Infectious Diseases and PhD postdoctoral scientists. The goal of the Vanderbilt ChIRP is to train and foster the careers of future leaders in academic biomedical science who are committed to research relevant to infections of children. There is no training program at Vanderbilt focused on the childhood infections, and ChIRP establishes a unique training niche for future basic and clinical investigators. This application proposes an innovative program that uses both 1) mentored research training and 2) "Peer Mentoring and Training" (PMT), a novel program that will partner clinical fellows and postdoctoral scientists to facilitate cross-disciplinary (Med-Grad, Grad-Med) training and experience. ChIRP-PMT training will result in basic scientists with training and in-depth understanding of clinical infectious disease, as well as clinical-translational investigators with a broad knowledge of the basic mechanisms of microbial pathogenesis. Key elements of the training program will be the use of primary mentors, individual development plans, and mentoring committees charged with regular review of scientific progress and career development. The assembled group of faculty mentors has been selected based on demonstrated research excellence, as well as long-term success in training of postdoctoral scientists and clinical fellows for research careers. The investigators hold primary appointments in the Departments of Pediatrics, Medicine, Microbiology and Immunology, and Preventive Medicine and together hold ~$34 million in extramural funding. Training in responsible conduct of research will be incorporated throughout the training term and will establish competencies in emerging areas such as high-biosafety containment, dual-use research, and research ethics in international collaborations. The applicant pool results from recruiting efforts focused on MD and MD/PhD Pediatric Infectious Diseases Fellow candidates and from PhD and MD/PhD postdoctoral scientists who apply to individual labs and through novel programs such as the Vanderbilt Office of Postdoctoral Affairs. Recruiting will emphasize clinical fellows and postdoctoral candidates from groups underrepresented in research. The proposal requests funded positions for two postdoctoral trainees each year, with four trainees total in the program during each year after year 1. The goal of ChIRP is to train one clinical fellow and one postdoctoral scientist per year, and to establish a group of clinical and postdoctoral scientists committed to an integrated faculty-and-peer mentoring research culture and experience. This request for support for ChIRP is based on the strength of the applicant pool, exceptional opportunities for training scientists in childhood infections, and an institutional commitment to the education of leaders in research in childhood infections. Relevance: The broad significance of this program will be realized through the academic and scholarly accomplishments of the trainees and discoveries of basic disease mechanisms and translational-clinical results directly relevant prevention and treatment of infectious diseases.

描述（由申请人提供）：本申请请求支持范德比尔特“儿童感染研究计划”（ChIRP），这是一项针对儿科传染病医学博士和医学博士/博士临床研究员的基础和临床转化科学的新博士后科学家培训计划博士后科学家。范德比尔特 ChIRP 的目标是培训和培养致力于儿童感染相关研究的学术生物医学科学未来领导者的职业生涯。范德比尔特大学没有针对儿童感染的培训计划，而 ChIRP 为未来的基础和临床研究人员建立了独特的培训领域。该申请提出了一项创新计划，该计划同时使用 1) 指导性研究培训和 2)“同行指导和培训”(PMT)，这是一项新颖的计划，将与临床研究员和博士后科学家合作，促进跨学科（医学研究生、研究生- Med）培训和经验。 ChIRP-PMT 培训将培养受过培训并深入了解临床传染病的基础科学家，以及对微生物发病机制的基本机制具有广泛了解的临床转化研究人员。培训计划的关键要素将是使用主要导师、个人发展计划和负责定期审查科学进展和职业发展的指导委员会。组成的教师导师团队是根据卓越的研究成果以及在博士后科学家和临床研究员的研究职业培训方面取得的长期成功而选出的。研究人员在儿科、医学、微生物学和免疫学以及预防医学等部门担任主要职务，总共拥有约 3400 万美元的外部资金。负责任的研究行为培训将纳入整个培训期间，并将建立高生物安全遏制、双重用途研究和国际合作中的研究伦理等新兴领域的能力。申请人库是通过招募医学博士和医学博士/博士儿科传染病研究员候选人以及向各个实验室申请的博士和医学博士/博士后科学家以及通过范德比尔特博士后事务办公室等新颖项目进行的招募工作而产生的。招聘将重点关注来自研究领域代表性不足的群体的临床研究员和博士后候选人。该提案要求每年为两名博士后实习生提供资助，第一年之后每年该项目总共有四名实习生。ChIRP 的目标是每年培养一名临床研究员和一名博士后科学家，并建立一批临床研究员和博士后科学家。和博士后科学家致力于整合教师和同行指导的研究文化和经验。对 ChIRP 的支持请求是基于申请人库的实力、培训儿童感染科学家的绝佳机会以及对儿童感染研究领导者教育的机构承诺。相关性：该项目的广泛意义将通过学员的学术成就、基本疾病机制的发现以及与传染病预防和治疗直接相关的转化临床结果来实现。