Gene-environment interaction and correlation in the Louisville Twin Study

路易斯维尔双胞胎研究中的基因-环境相互作用和相关性

基本信息

批准号：
8798096
负责人：
ERIC Nathan TURKHEIMER
金额：
$ 16.57万
依托单位：
UNIVERSITY OF VIRGINIA
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-09-30 至 2016-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8798096
关键词：
Adolescence Age Age-Years American Archives Area Attenuated Biometry Characteristics Child Childhood Cognitive Communities Complex Computers Data Data Collection Data Set Deltastab Development Environment Equation Family health status Family member Funding Future Genes Genetic Heritability Human Human Development Individual Intelligence Life Measurement Medical Methodology Methods Modeling Paper Participant Performance Phenotype Philadelphia Population Preparation Process Public Health Publications Publishing Recontacts Recovery Relative (related person)Rewards Role Sampling Schools Series Siblings Socioeconomic Status Study models System Testing Twin Multiple Birth Twin Studies Uncertainty Videotape Work attenuation base behavioral health emerging adult follow-up gene environment interaction infancy insight interest member middle age psychologic public health relevance restoration wasting

项目摘要

DESCRIPTION (provided by applicant): The Louisville Twin Study (LTS) was established in 1959, and continuously funded for forty years; data collection was terminated in 2003. The LTS includes data on over 1500 twins born in the Louisville area. Data were collected on physical and medical parameters, health, families, school performance and cognitive ability at 16 different measurement occasions between three months and fifteen years of age. Repeated measurements of cognitive ability will be used to answer important questions about the causes of differences in ability through development. Data will be fit to an integrative model that will provide explanations of some of the most important observations regarding intellectual development during childhood: the importance of genetic factors increases throughout childhood, the role of genetics is diminished among children raised in impoverished environments, and the temporal stability of individual twins and siblings relative their family members increases with age. The hypothesis is that all three phenomena occur as a result of a process of ongoing matching of children to environments, through which children with the greatest observed cognitive abilities are exposed to the most enriching environments. In addition, funds are requested to support the ongoing recovery and archiving of the data from the LTS, so they can eventually be made available to the scientific community at large.

描述（由申请人提供）：路易斯维尔双胞胎研究（LTS）成立于1959年，并不断资助40年；数据收集于2003年终止。LTS包括有关路易斯维尔地区出生的1500多个双胞胎的数据。收集有关物理和医疗参数，健康，家庭，学校表现和认知能力的数据，在三个月至15岁之间的16个不同测量场合。重复测量认知能力将用于回答有关通过发展能力差异的原因的重要问题。数据将适合一个综合模型，该模型将提供有关儿童期间有关智力发展的一些最重要观察的解释：遗传因素在整个童年时期的增加，遗传学的作用在贫困环境中培养的儿童中降低，以及单个双胞胎和兄弟姐妹的家庭成员的临时稳定性随着年龄的增长而增加。假设是，这三种现象都是由于儿童与环境的持续匹配过程而发生的，而这些环境的持续匹配的过程中，观察到的认知能力最高的儿童暴露于最丰富的环境中。此外，还要求资金支持LTS的持续恢复和归档数据，因此最终可以向整个科学界提供它们。