Reward processing in frontotemporal dementia

额颞叶痴呆的奖励处理

基本信息

批准号：
8765655
负责人：
DAVID C PERRY
金额：
$ 16.14万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-08-15 至 2019-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8765655
关键词：
Affect Aging Alzheimer&apos s Disease Anatomy Animal Disease Models Animal Model Anterior Behavior Behavioral Behavioral Symptoms Biological Biological Markers Biometry Brain Brain region California Clinical Research Clinical Trials Cognitive Data Collection Dementia Desire for food Development Diagnosis Disease Disease model Disinhibition Dopamine Eating Disorders Educational process of instructing Elderly Elements Emotional Family Food Frontotemporal Dementia Functional Imaging Future Galvanic Skin Response Globus Pallidus Goals Heart Rate Hyperphagia Impairment Individual Insula of Reil Knowledge Laboratories Laboratory Finding Lead Learning Life Measures Memory Mentored Patient-Oriented Research Career Development Award Mentors Methods Modality Modeling Neurodegenerative Disorders Neurologist Neurology Neurosciences Nucleus Accumbens Opioid Pathway interactions Patients Pharmacological Treatment Prefrontal Cortex Problem behavior Process Psychiatrist Psychophysiology Punishment Regulation Reporting Research Research Personnel Rewards San Francisco Satiation Serotonin Severities Sex Behavior Specialist Staging Stimulus Structure Substance abuse problem Symptoms System Task Performances Techniques Testing Training Translating Universities Update Variant Ventral Striatum Ventral Tegmental Area Work base career craving daily functioning disorder control drug testing effective therapy executive function experience improved informant neuroimaging neuropsychiatry novel olfactory stimulus patient oriented professor public health relevance response reward processing social symptom management tool

项目摘要

DESCRIPTION (provided by applicant): This is an application for a K23 award for Dr. David Perry, a behavioral neurology fellow at the University of California, San Francisco Memory and Aging Center (MAC). Dr. Perry is establishing himself as a young investigator in patient-oriented clinical research of reward processing in neurodegenerative disease. This K23 award will provide Dr. Perry with the support necessary to accomplish the following goals: 1) to gain expertise in neurodegenerative disease and neuropsychiatric symptom management; 2) to develop proficiency in the use and analysis of structural and functional neuroimaging; 3) to gain experience in the use of psychophysiological measures; 4) to advance his knowledge of biostatistics [and clinical trials]; and 5) to develop an independent clinical research career. To achieve these goals, Dr. Perry has assembled a mentoring team comprised of two primary mentors: Dr. Howard Rosen (a neurologist with expertise in neurodegenerative disease, psychophysiology, and neuroimaging analysis) and Dr. Joel Kramer (a neuropsychologist with expertise in cognitive and behavioral systems); one co-mentor, Dr. Bruce Miller (neurologist with expertise in behavioral neurology, neurodegenerative disease, and clinical research); and five consultants: [Dr. Craig Nelson (a geriatric psychiatrist), Dr. Chiadi Onyike (a geriatric psychiatrist and specialist in behavioral variant frontotemporal dementia (bvFTD)), Dr. Adam Boxer (a neurologist with expertise in clinical trials in bvFTD),] Dr. John Neuhaus (a biostatistician) and Dr. Mark D'Esposito (a professor of neuroscience with expertise in functional neuroimaging and reward processing). The proposed research will examine reward processing in bvFTD. Reward processing involves a determination of what an individual will pursue or work for, such as food, money, or social approval. Dr. Perry will administer laboratory tasks of reward processing to patients with bvFTD, Alzheimer's disease, and healthy control subjects to determine the aspect of valuation of reward that is altered in bvFTD (Aim 1). Dr. Perry will correlate the findings from these laboratory tasks with structural and functional imaging to determine the anatomic correlates of these behaviors (Aim 2) and with real-life functional measures to determine the effect reward processing changes have in patients' lives (Aim 3). Data collection will take place at the MAC. The results of this research will improve understanding of the behavioral symptoms in bvFTD, will direct future studies into symptomatic treatment in the illness, will provide objective tests to distinguish neurodegenerative diseases, and will offer reward-based measures as an additional tool for use in animal models of bvFTD. This K23 training will enable Dr. Perry to apply concepts of reward processing to the understanding of other neurodegenerative diseases.

描述（由申请人提供）：这是加利福尼亚大学旧金山记忆和老化中心（MAC）的行为神经病学研究员David Perry博士的K23奖。佩里博士正在建立自己是一名年轻研究者，研究了神经退行性疾病的奖励处理临床研究。该K23奖将为佩里博士提供实现以下目标所需的支持：1）获得神经退行性疾病和神经精神症状管理方面的专业知识； 2）在结构和功能神经影像学的使用和分析方面提高熟练程度； 3）获得使用心理生理措施的经验； 4）提高他对生物统计学的了解[和临床试验]； 5）发展独立的临床研究职业。为了实现这些目标，佩里博士组建了一个由两位主要指导者组成的指导团队：霍华德·罗森（Howard Rosen）博士（霍华德·罗森（Howard Rosen）博士（具有神经退行性疾病，心理生理学和神经成像分析的专业知识）和乔尔·克雷默（Joel Kramer）（具有认知和行为系统专业知识的神经心理学家）；一位联合学者布鲁斯·米勒（Bruce Miller）博士（具有行为神经病学，神经退行性疾病和临床研究专业知识的神经科学家）；和五位顾问：[博士Craig Nelson (a geriatric psychiatrist), Dr. Chiadi Onyike (a geriatric psychiatrist and specialist in behavioral variant frontotemporal dementia (bvFTD)), Dr. Adam Boxer (a neurologist with expertise in clinical trials in bvFTD),] Dr. John Neuhaus (a biostatistician) and Dr. Mark D'Esposito (a professor of神经科学具有功能性神经影像和奖励处理方面的专业知识）。拟议的研究将检查BVFTD中的奖励处理。奖励处理涉及确定个人将追求或工作的确定，例如食物，金钱或社会认可。佩里博士将对BVFTD，阿尔茨海默氏病和健康对照受试者的患者执行实验室奖励处理，以确定BVFTD改变的奖励估值方面（AIM 1）。佩里博士将将这些实验室任务的发现与结构和功能成像相关联，以确定这些行为的解剖相关性（AIM 2）以及现实生活中的功能措施，以确定奖励处理变化对患者的生活的影响（AIM 3）。数据收集将在Mac进行。这项研究的结果将改善对BVFTD的行为症状的理解，将未来的研究将未来的研究用于疾病中的有症状治疗，将提供客观的测试以区分神经退行性疾病，并将提供基于奖励的措施作为BVFTD动物模型中使用的附加工具。这种K23培训将使佩里博士能够将奖励处理的概念应用于对其他神经退行性疾病的理解。