Sensitive tumor detection with magnetomotive imaging

利用磁动成像进行灵敏的肿瘤检测

基本信息

批准号：
8676751
负责人：
Xiaohu Gao
金额：
$ 45.1万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-08-01 至 2016-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8676751
关键词：
Academy Acoustics Address Adverse effects Animal Model Animals Area Binding Biological Biological Markers Biomedical Engineering Censuses Clinical Code Collaborations Communication Contrast Media Coupled Detection Development Diagnosis Diagnostic Elasticity Electromagnetics Engineering Environment Faculty Feedback Fostering Future Goals Hyperthermia Image Imaging technology Interdisciplinary Study Lasers Life Magnetism Malignant Neoplasms Medical Medicine Modeling Molecular Monitor Mus Nanotechnology Nature Neoplasm Metastasis Noise Nude Mice Optics Performance Phase Positioning Attribute Preparation Procedures Property Prostatic Neoplasms Records Research Research Personnel SCID Mice Sampling Series Signal Transduction Specificity System Techniques Technology Technology Assessment Temperature Testing Therapeutic Therapeutic Effect Time Tissues Transducers Translations Tumor Biology Ultrasonography Urology Work Xenograft Model absorption anticancer research base bioimaging college design detector effective therapy flexibility hyperthermia treatment image guided therapy imaging modality imaging probe improved in vivo in vivo imaging innovation instrument instrumentation medical schools member molecular imaging nanobiotechnology nanoparticle nanoprobe new technology novel outcome forecast particle photoacoustic imaging research study response signal processing success technology development tumor uptake

项目摘要

DESCRIPTION (provided by applicant): This application directly addresses "PQ13. Can tumors be detected when they are two to three orders of magnitude smaller than those currently detected with in vivo imaging modalities?" To date molecular imaging technologies have had limited clinical impact to date for a number of reasons. One of the primary ones is the inadequate contrast specificity of molecular contrast agents due to non-specific agent binding and background signals from tissue. Major increase in detection sensitivity would provide a fundamental change in how we diagnose and treat cancers. In this context, the overarching goal of this project is to develop an ultrasensitive platform technology based on a recent breakthrough we made on magnetomotion-based imaging-contrast enhancement (Nat. Commun. 2010). We have shown improvement of imaging S/N ratio of 3 orders or magnitude in phantoms by incorporating magnetic properties into imaging contrast agents. Through this project, we plan to further develop this innovative and powerful background suppression technique for in vivo tumor imaging and image-guided therapy. We will use photoacoustic imaging as a model, but the innovative concept and algorism can be expanded to virtually any other molecular imaging modalities involving contrast agents. This platform technology is also compatible with future major developments in the field of biomedical imaging, such as development of more specific probes and more sensitive detectors.

描述（由申请人提供）：此申请直接解决“ PQ13。肿瘤比当前使用体内成像方式所检测到的肿瘤小时到三个数量级时是否检测到它们？”迄今为止，由于多种原因，分子成像技术的临床影响有限。主要的是由于非特异性剂结合和组织的背景信号而导致的分子对比剂的对比度不足。检测敏感性的重大提高将为我们诊断和治疗癌症的诊断方式提供根本性的改变。在这种情况下，该项目的总体目标是基于我们对基于磁化的成像对比度增强的最新突破（Nat。Commun。2010）的最新突破，开发一种超敏平台技术。我们已经通过将磁性特性纳入成像对比度剂中显示了幻象中3个顺序或幅度的成像S/N比的改进。通过该项目，我们计划进一步开发这种创新且强大的背景抑制技术，用于体内肿瘤成像和图像引导的治疗。我们将使用光声成像作为模型，但是创新的概念和算法可以扩展到几乎任何其他涉及对比剂的分子成像方式。该平台技术还与生物医学成像领域的未来主要发展兼容，例如开发更具体的探针和更敏感的探测器。