Acute and Chronic In vivo Effects of Engineered Nanomaterials

工程纳米材料的急性和慢性体内效应

• 批准号: 8282801
• 负责人: Terry Gordon
• 金额: $ 52.33万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-24 至 2015-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8282801
• 关键词: Acute; Address; Apoptosis; Breathing; Cardiovascular system; Cell Differentiation process; Cell Proliferation; Cerium; Chronic; Development; Discipline of obstetrics; Engineering; Exposure to; Hepatic; Low Birth Weight Infant; Lung; Malignant - descriptor; Modeling; Molecular; Nickel; Organ; Process; Relative (related person); Silver; Testing; Toxic effect; age effect; aged; biological adaptation to stress; fetal; in vivo; nanomaterials; nanoparticle

This research project focuses on the role of physical-chemical characteristics of nanoparticles in their interactions with cells, organelles, and organs after in vivo exposure via the inhalation route. During the first year, we will assess the biokinetics and toxicity of 3 selected nanoparticles under three different physical-chemical states. An important goal of our research will be the evaluation of acute vs. chronic toxicity of inhaled nanoparticles. We propose to compare the acute and chronic toxicity in test animals exposed by inhalation to cerium, nickel, and silver nanoparticles. Each of these commercially-important nanomaterials (and other Consortium-selected nanomaterials) will be dynamically generated for these inhalation studies. The nose-only exposure system has been constructed and the nanoparticle generation system is almost complete (as of 2/11). Tasks completed include: 1. testing of furnace system to fully oxidize aged nanoparticles 2. construction ofthe aging system in the animal housing facility 3. ordering of test material for nanoparticle generation 4. recruitment of an exposure assessment student to participate in the research for his Master's thesis

该研究项目重点研究纳米颗粒通过吸入途径暴露于体内后，其物理化学特性在与细胞、细胞器和器官相互作用中的作用。第一年，我们将评估 3 种选定的纳米粒子在三种不同物理化学状态下的生物动力学和毒性。 我们研究的一个重要目标是评估吸入纳米颗粒的急性与慢性毒性。我们建议比较吸入铈、镍和银纳米颗粒的试验动物的急性和慢性毒性。这些具有商业重要性的纳米材料（以及联盟选择的其他纳米材料）中的每一种都将为这些吸入研究动态生成。仅鼻子暴露系统已经构建完毕，纳米颗粒生成系统也已基本完成（截至2/11）。完成的任务包括： 1. 炉系统测试以充分氧化老化的纳米颗粒 2.动物圈养设施老化系统的建设 3. 纳米颗粒生成测试材料的订购 4. 招募暴露评估学生参与硕士论文研究