Aging Research at the 2010 through 2014 ASHEcon Biennial Conferences

2010 年至 2014 年 ASHEcon 双年度会议上的老龄化研究

基本信息

批准号：
8291259
负责人：
Jody L. Sindelar
金额：
$ 2.5万
依托单位：
YALE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-07-01 至 2015-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8291259
关键词：
Achievement Affect Age Aging Aging-Related Process Alzheimer&apos s Disease American Amino Acids Area Attention Basic Science Biochemistry Biogenesis Biomedical Research Cell physiology Cells Commit Communicable Diseases Community Health Development Diabetes Mellitus Diffusion Discipline Disease Economics Educational process of instructing Elderly Ensure Environment Equilibrium Evolution Explosion Failure Fertilization Financial Support Funding Future Gender Generations Goals Growth Health Health Care Reform Health Insurance Health Policy Health behavior Hearing Heart Diseases Heat shock proteins Homeostasis Hospitals Humanities International Laboratories Life Long-Term Care Malignant Neoplasms Mediating Medicare Metabolic Diseases Methods Molecular Chaperones Neurodegenerative Disorders Oral Organism Outcome Paper Parkinson Disease Pathway interactions Physicians Policies Polymers Preventive Process Professional Organizations Proteins Proteolysis Quality Control Quality of Care Regulation Research Research Personnel Retirement Role Scientist Services Signal Transduction Pathway Societies Stress System Technology Time Training Translating Treatment outcome Underrepresented Minority Universities Wisconsin abstracting age related base biological adaptation to stress blind comparative effectiveness cost experience health economics high standard in vivo innovation interest lectures meetings next generation normal aging payment polyglutamine polypeptide posters protein folding protein function protein misfolding protein transport racial and ethnic response success symposium web site

项目摘要

ABSTRACT This proposal is a request for partial financial support for a meeting on Molecular Chaperones and Stress Responses to be held from May 4 - 8, 2010 at Cold Spring Harbor Laboratory. This meeting is the premier international format for presentation of new results in this area, and is attended by representatives from virtually every major laboratory in the field. The explosion of new information on how the folded state of proteins is acquired and maintained in vivo and the involvement of this process in an increasing number of disease states and in normal aging guarantees the excitement of this meeting. Among the highlights of the meeting will be sessions devoted to: (1) Protein misfolding and disease, emphasizing the role of alternative folding pathways in protein biogenesis and lifecycle and mounting evidence for chaperone involvement in Alzheimer's Disease, polyglutamine diseases and the aging process (2) new structural and mechanistic information on some intensively studied chaperones, (3) the role of chaperones in diverse cellular transactions and the signal transduction pathways that integrate them, (4) the crosstalk between protein folding and proteolysis mediated by chaperones, (5) how the various protein folding and quality control systems in a cell function together to provide a robust protein folding environment and how the breakdown of such protein homeostasis (proteostasis) contributes to disease and normal aging, (6) the diverse protein quality control strategies used by a cell to ensure the integrity of the secretory pathway during times of protein folding stress. The field of heat shock proteins and molecular chaperones has grown rapidly and draws interest not only from traditional scientific disciplines in the basic sciences but also from numerous areas of biomedical research including neurodegenerative disease, infectious diseases, cancer, heart disease and aging. The meeting will include seven lecture and three poster sessions. The proposed sessions include: I- Chaperone Biochemistry & Protein Folding, II- Chaperone Function in Disease and Development, III- Diseases of Protein Misfolding IV- Quality Control & Protein Trafficking V- Evolution and Regulation of Protein Folding Machines, VI- Chaperones and Proteolysis, and VII- Manipulating Chaperone Networks and Protein Folding Pathways. Each session will consist of eight to nine oral presentations and will be chaired by an invited speaker. A maximum of two additional speakers will be pre-invited per session and the remainder will be selected from submitted abstracts. This balance of talks allows the meeting to feature presentations by leading scientists, to be responsive to exciting new developments, to encourage diverse participation and to recognize new investigators. The subsequent meetings (2012 and 2014) will follow a similar format and will include topics highly relevant to the current research at the time of the meeting.

抽象的该提案请求为 2010 年 5 月 4 日至 8 日在冷泉港实验室举行的分子伴侣和应激反应会议提供部分财政支持。这次会议是展示该领域新成果的首要国际形式，几乎该领域每个主要实验室的代表都出席了会议。关于体内蛋白质折叠状态如何获得和维持的新信息的激增，以及这一过程在越来越多的疾病状态和正常衰老中的参与，保证了这次会议的兴奋。会议的亮点包括以下会议：(1) 蛋白质错误折叠和疾病，强调替代折叠途径在蛋白质生物发生和生命周期中的作用，并提供越来越多的证据表明伴侣参与阿尔茨海默病、多聚谷氨酰胺疾病和衰老过程（2 ）关于一些深入研究的伴侣的新结构和机制信息，（3）伴侣在不同细胞事务中的作用以及整合它们的信号转导途径，（4）蛋白质折叠和蛋白质折叠之间的串扰分子伴侣介导的蛋白水解，(5) 细胞中的各种蛋白质折叠和质量控制系统如何共同发挥作用，提供强大的蛋白质折叠环境，以及这种蛋白质稳态（蛋白质稳态）的破坏如何导致疾病和正常衰老，(6)细胞使用多种蛋白质质量控制策略来确保蛋白质折叠应激期间分泌途径的完整性。热休克蛋白和分子伴侣领域发展迅速，不仅引起了基础科学中传统科学学科的兴趣，也引起了包括神经退行性疾病、传染病、癌症、心脏病和衰老在内的众多生物医学研究领域的兴趣。会议将包括七场演讲和三场海报会议。拟议的会议包括：I- 伴侣生物化学和蛋白质折叠，II- 伴侣在疾病和发育中的功能，III- 蛋白质错误折叠疾病 IV- 质量控制和蛋白质运输 V- 蛋白质折叠机器的进化和调节，VI- 伴侣和蛋白水解和 VII-操纵伴侣网络和蛋白质折叠途径。每场会议将包括八到九次口头报告，并由一位受邀演讲者主持。每场会议将预先邀请最多两名额外发言人，其余发言人将从提交的摘要中选出。这种平衡的会谈使得会议能够以顶尖科学家的演讲为特色，对令人兴奋的新进展做出反应，鼓励多元化参与并认可新的研究人员。随后的会议（2012 年和 2014 年）将遵循类似的形式，并将包括与会议时当前研究高度相关的主题。