Diet, Insulin, Dopamine, and Reward

饮食、胰岛素、多巴胺和奖励

基本信息

批准号：
8716599
负责人：
Kenneth D Carr
金额：
$ 20.97万
依托单位：
NEW YORK UNIVERSITY SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2013
资助国家：
美国
起止时间：
2013-11-15 至 2015-10-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8716599
关键词：
Acetylcholine Acute Address Award Axon Back Behavior Behavioral Binding Brain Budgets Buffers Chronic Cocaine Complement Corpus striatum structure Data Diet Dopamine Eating Endocrine Environment Equilibrium Expenditure Fatty acid glycerol esters Feeding behaviors Financial compensation Food Frequencies Future Goals Hormones Hyperactive behavior Hypothalamic structure IACUC Immunohistochemistry In Vitro Injection of therapeutic agent Insulin Insulin Receptor Interneurons Knockout Mice Laboratories Lateral Left Mediating Microinjections Middle Hypothalamus Mus Nicotinic Receptors Nucleus Accumbens Obesity Pathway interactions Pharmaceutical Preparations Physiologic pulse Presynaptic Terminals Progress Reports Protocols documentation Rattus Records Regimen Regulation Relative (related person)Resources Rewards Rice Rodent Role Satiation Signal Pathway Slice Sucrose Surface Syndrome Testing Time Transgenic Mice Translating Ventral Tegmental Area Wages Whole-Cell Recordings analog base behavior influence cholinergic cost dopamine transporter drug of abuse extracellular feeding food restriction in vivo insulin sensitivity neuronal cell body neurotransmission novel preference psychostimulant putamen receptor sensitivity research study response reward circuitry uptake

项目摘要

As a consequence of Super-storm Sandy and its aftermath, two significant losses set back progress on our multi-PI project, 1 R01 DA033811, Diet, Insulin, Dopamine, and Reward, PIs: Margaret Rice (contact), Kenneth Carr, and Maarten Reith. The first was lost time, and the second was loss of a transgenic mouse line, in which acetylcholine (ACh) was genetically deleted (as described in Patel et al., Nat. Commun., 2012). We are requesting a with-cost extension of 4 months, and a supplement to re-establish this key mouse line. Our laboratories are all fully functional, and we have current IACUC approval for all experiments in this project: Rice protocol 120313-02, approved 4/9/13; Carr protocol 120604-02, approved 2/1/2013; Reith protocol 120807-01, approved 8/30/2012. As also noted in our recently submitted Progress Report, the unobligated balance on this project was 36% of the total budget as of 5/31/13 ($187,879 of the total award, which was $525,864, direct + indirect). It should be noted that 30% carry-over was necessarily expected because Year 1 was truncated by 30% (to 8.5 mo. 9/15/2012 - 5/31/2013). The small additional balance (6%) reflected some decrease in supply expenditures because of down-time in Sandy (although salary support necessarily continued), as well as conservative spending to buffer future budget years in which expenses are expected to increase, and the annual award amount to remain flat or even decrease, as occurred in the current budget year (Year 2). Thus, the current unobligated balance is absolutely essential to achieve the goals of the original application. The present request for a with-cost extension and supplement is a completely separate issue that addresses compensation to restore losses of time and resources from Sandy.

由于超级风暴桑迪及其后果，两起重大损失阻碍了我们的进展多 PI 项目，1 R01 DA033811，饮食、胰岛素、多巴胺和奖励，PI：Margaret Rice（接触），肯尼思·卡尔和马丁·里斯。第一个是时间的损失，第二个是转基因小鼠品系的损失，其中乙酰胆碱 (ACh) 被基因删除（如 Patel 等人，Nat. Commun.，2012 年所述）。我们请求延长 4 个月的费用，并提供补充以重新建立该关键鼠标系列。我们的实验室功能齐全，目前所有实验均已获得 IACUC 批准项目：水稻协议 120313-02，2013 年 4 月 9 日批准； Carr 协议 120604-02，2013 年 2 月 1 日批准；里斯议定书 120807-01，2012 年 8 月 30 日批准。正如我们最近提交的进度报告中还指出的那样，截至 2013 年 5 月 31 日，该项目的未承付余额占总预算的 36%（总拨款额为 187,879 美元，直接+间接费用为 525,864 美元）。应该指出的是，30% 的结转是必然的预期因为第 1 年被截断了 30%（至 8.5 月 9/15/2012 - 5/31/2013）。小额额外余额（6%）反映了由于桑迪停工导致供应支出有所减少（尽管工资支持必然继续），以及保守支出以缓冲未来预算年度的支出预计会增加，而年度奖励金额将持平甚至减少，就像当前的情况一样预算年（第二年）。因此，当前的未承付余额对于实现本组织的目标绝对必要。原始申请。目前的付费延期和补充请求是完全独立的解决补偿问题，以恢复桑迪造成的时间和资源损失。