Telluride Workshop on Challenges in RNA Structural Modeling and Design

关于 RNA 结构建模和设计挑战的 Telluride 研讨会

• 批准号: 8779815
• 负责人: Anna Marie Pyle
• 金额: $ 0.5万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-11 至 2017-07-06
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8779815
• 关键词: Address; Archives; Area; Biological Process; Catalysis; Cell physiology; Collaborations; Communication; Computing Methodologies; Congresses; Databases; Discipline; Educational workshop; Engineering; Experimental Models; Feedback; Gene Expression; Genomics; Knowledge; Molecular; Outcome; Participant; Play; Progress Reports; RNA; Resolution; Role; Scientist; Simulate; Statistical Methods; Structural Models; Structure; United States National Institutes of Health; Work; design; frontier; improved; innovation; mathematical methods; meetings; model design; novel; novel strategies; practical application; public health relevance; success; symposium; working group; Address; Archives; Area; Biological Process; Catalysis; Cell physiology; Collaborations; Communication; Computing Methodologies; Congresses; Databases; Discipline; Educational workshop; Engineering; Experimental Models; Feedback; Gene Expression; Genomics; Knowledge; Molecular; Outcome; Participant; Play; Progress Reports; RNA; Resolution; Role; Scientist; Simulate; Statistical Methods; Structural Models; Structure; United States National Institutes of Health; Work; design; frontier; improved; innovation; mathematical methods; meetings; model design; novel; novel strategies; practical application; public health relevance; success; symposium; working group

DESCRIPTION (provided by applicant): The heightened appreciation for the central role of RNA molecules in all cellular processes - from catalysis to control of gene expression to cellular differentiation - combined with the practical applications of synthetic RNAs in biomedicine and biomolecular engineering have raised new challenges regarding RNA structure analysis, prediction, and design to both experimental and theoretical scientists. These challenges have produced many innovative approaches, including interdisciplinary efforts, to analyze, predict, simulate, and design RNA molecules. While many successes have been reported, progress in the field has been hampered by limited experimental resolution and an incomplete understanding of RNA tertiary structure, especially for large RNAs. Though RNA structure is believed to be hierarchical, the difficult problem of understanding and predicting its tertiary structure from its primary as well as secondary structure remains unsolved in general. In addition, some database issues and limited coordination of RNA archives have emerged. To advance this important scientific frontier, we will hold TSRC meetings in Summers 2014 and 2016 to bring leading experimentalists and modelers to discuss and advance the field. We aim to create a core working group to bring together scientists working on both the genomic and molecular levels of RNA using novel experimental, mathematical, statistical, and computational methods. By familiarizing scientists from disparate disciplines with the challenges, and presenting current efforts, advances, and ideas, we hope to catalyze new approaches and collaborations in this important field, identify gaps in knowledge and areas for progress, and address these gaps after the first meeting via focused problems by the second meeting in 2016. Support by the NIH will help not only improve the workshop, but also provide NIH direct feedback on the participants' dialog and outcomes via resulting meeting reports and direct communications.

描述（由申请人提供）：对RNA分子在所有细胞过程中的核心作用的增强 - 从催化到控制基因表达到细胞分化 - 结合了合成RNA在生物医学和生物分子工程中的实际应用，都提高了有关RNA结构分析，预测和设计科学的新挑战。这些挑战产生了许多创新的方法，包括跨学科的努力，以分析，预测，模拟和设计RNA分子。尽管已经报道了许多成功，但该领域的进展受到有限的实验分辨率和对RNA三级结构的不完全理解的阻碍，尤其是对于大型RNA。尽管RNA结构被认为是层次结构，但理解和预测其初级和二级结构的三级结构的困难问题一般仍未解决。此外，出现了一些数据库问题和RNA档案的有限协调。为了推进这一重要的科学领域，我们将在2014年和2016年举行TSRC会议，以带来领先的实验家和建模者讨论和推进该领域。我们旨在建立一个核心工作组，以使用新型的实验，数学，统计和计算方法将科学家汇总为RNA基因组和分子水平的科学家。通过使科学家从不同的纪律中熟悉挑战，并提出当前的努力，进步和思想，我们希望催化在这个重要领域中的新方法和协作，确定知识和进步领域的差距，并在2016年通过第二次会议通过第二次会议通过重点问题来解决这些差距，并通过NIH的支持，并不只能在NIH上提供越来越多的企业。直接通信。